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Phys Med Biol ; 43(2): 325-37, 1998 Feb.
Article in English | MEDLINE | ID: mdl-9509529

ABSTRACT

The dosimetry of charged-particle beams is frequently performed by measuring the ionization yield produced in gas-filled ionization chambers and converting it into absorbed dose using the mean energy W expended in a gas per ion pair formed, or its differential value omega for the filling gas. Because of the increasing importance of proton therapy and the lack of accurate values of W and omega at high proton energies in particular, we investigated the ionization yield formation by protons in air and methane-based tissue-equivalent gas in the energy range up to 500 MeV. For this purpose, we analysed the available experimental values of W and omega and, in a second step, investigated the ionization-yield formation by protons as a function of their initial energy using an analytical method based on the Spencer-Fano equation in the framework of the continuous-slowing-down approximation. To estimate possible ionization losses which can be expected if the ionometric method is applied in the case of an incomplete secondary-electron equilibrium, a new analytical model has been developed which can be used to calculate the radial distribution of the ionization yield produced by secondary electrons around high-energy proton tracks.


Subject(s)
Phantoms, Imaging , Proton Therapy , Radiotherapy Planning, Computer-Assisted , Radiotherapy, High-Energy , Air , Electrons , Gases , Humans , Models, Theoretical , Radiotherapy Dosage , Reproducibility of Results
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