1.
Bioorg Med Chem Lett
; 11(17): 2225-8, 2001 Sep 03.
Article
in English
| MEDLINE
| ID: mdl-11527703
ABSTRACT
Stemming from work on a previous clinical candidate, loviride, and other alpha-APA derivatives, a new series of potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been synthesized. The ITU analogues, which contain a unique diarylated imidoyl thiourea, are very active in inhibiting both wild-type and clinically important mutant strains of HIV-1.