Subject(s)
Estradiol Congeners/adverse effects , Menopause/drug effects , Uterine Neoplasms/chemically induced , Adult , Aged , Breast Neoplasms/prevention & control , Drug Administration Schedule , Drug Therapy, Combination , Endometrial Hyperplasia/chemically induced , Estradiol Congeners/therapeutic use , Female , Humans , Middle Aged , Osteoporosis/prevention & control , Progesterone Congeners/therapeutic use , RiskABSTRACT
A review of 2 cases of 46,XY pure gonadal dysgenesis (Swyer's syndrome) is presented. In one, bilateral gonadoblastomas with dysgerminomas were found at the time of laparotomy for gonadal extirpation. The second case was of interest because of endometriosis on the mesosalpinx, an entity heretofore undescribed in pure gonadal dysgenesis.
Subject(s)
Dysgerminoma/complications , Endometriosis/complications , Gonadal Dysgenesis, 46,XY/complications , Gonadal Dysgenesis/complications , Adolescent , Broad Ligament/pathology , Dysgerminoma/pathology , Endometriosis/pathology , Female , Gonadal Dysgenesis, 46,XY/pathology , Humans , Male , Phenotype , Testis/pathologyABSTRACT
Homologous artificial insemination (AIH), with the use of a split-ejaculate technique, was performed in 62 couples following a complete infertility investigation. Fifty per cent of all men had a sperm count less than 50 million per milliliter and 80 per cent had sperm motility less than 50 per cent. More important, 85 per cent of the initial semen samples had greater than 40 per cent abnormal forms and liquefaction was delayed beyond 20 minutes in 67 per cent of specimen. The pregnancy rate for the 28 women who underwent the prescribed course of six or more inseminations was 46.4 per cent, for the group of 60 who received split-ejaculate AIH, 21.6 per cent; and for the entire group of 62 couples, 24.2 per cent. In the split-ejaculate group 50 per cent of the pregnancies resulted in first-trimester abortions. It is suggested that the pregnancy wastage in these couples might be due to male factors.
