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J Am Acad Dermatol ; 40(1): 69-72, 1999 Jan.
Article in English | MEDLINE | ID: mdl-9922014

ABSTRACT

In an open uncontrolled study of 3 patients with balanitis xerotica obliterans we have observed significant improvement after long-term systemic antibiotic therapy. Two of the patients noticed softening of the skin as well as disappearance of pruritus, tenderness, and inflammatory changes within 3 weeks of receiving oral and intramuscular penicillin. The third patient experienced the same degree of improvement after a regimen of dirithromycin, 500 mg/day. Stopping the antiobiotic for 1 month resulted in relapse, with improvement again on resumption.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Balanitis/drug therapy , Penicillins/therapeutic use , Adult , Erythromycin/analogs & derivatives , Erythromycin/therapeutic use , Humans , Macrolides , Male , Middle Aged , Penicillin G/therapeutic use , Penicillin V/therapeutic use , Time Factors
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