Subject(s)
DEAD-box RNA Helicases , Ovarian Neoplasms , Ribonuclease III , Sertoli-Leydig Cell Tumor , DEAD-box RNA Helicases/genetics , Female , Humans , Mutation , Ovarian Neoplasms/genetics , Ovarian Neoplasms/pathology , Ribonuclease III/genetics , Sertoli-Leydig Cell Tumor/genetics , Sertoli-Leydig Cell Tumor/pathologyABSTRACT
Central giant cell granuloma (CGCG) is a benign but locally aggressive intraosseous lesion of the mandible. Historically, it is treated by curettage or resection. Medical therapy is indicated when surgery is associated with increased morbidity or in adjuvant setting to decrease recurrence. Treatment of CGCG with denosumab, a receptor activator of nuclear factor kappa-beta (RANK) ligand inhibitor, is not well studied, especially in children. Here, we describe our experience with the use of denosumab in the treatment of six children with CGCG. All patients had a favorable response with manageable side effects, which suggests that denosumab is an effective treatment option without increased morbidity.
Subject(s)
Bone Density Conservation Agents/therapeutic use , Denosumab/therapeutic use , Granuloma, Giant Cell/drug therapy , Child , Child, Preschool , Female , Follow-Up Studies , Granuloma, Giant Cell/pathology , Humans , Male , PrognosisSubject(s)
Antineoplastic Agents/therapeutic use , Desmoplastic Small Round Cell Tumor/drug therapy , Embolization, Therapeutic/methods , Hypersplenism/therapy , Thrombocytopenia/therapy , Child , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Etoposide/therapeutic use , Female , Humans , Ifosfamide/therapeutic use , Vincristine/therapeutic useABSTRACT
Cefepime is increasingly used as empiric treatment for fever in the setting of neutropenia. We present a patient with acute-on-chronic renal disease who received cefepime at the appropriate dose for his glomerular filtration rate but developed cefepime-associated encephalopathy. Here, we review neurologic toxicities of cefepime and present suggestions for work-up and management.
