Two Rhabdoviridae: Dillard's Draw virus, a putative new virus, and Merida virus from Culex tarsalis (Diptera: Culicidae) in New Mexico, USA.

The U.S. Air Force conducts vector and arbovirus surveillance worldwide. We report on two Rhabdoviridae detected at Holloman Air Force Base in Otero County, New Mexico including the nearly complete 11-kb genome of Merida virus, which was not previously known from the USA, and a novel virus tentatively named Dillard's Draw virus. Merida virus was previously only known from Mexico. Dillard's Draw virus represents a novel arbovirus most closely related to an avian pathogen from Australia and shares some genetic similarity to Durham virus from the eastern United States.

Mechanochemical route to the synthesis of nanostructured Aluminium nitride.

Hexagonal Aluminium nitride (h-AlN) is an important wide-bandgap semiconductor material which is conventionally fabricated by high temperature carbothermal reduction of alumina under toxic ammonia atmosphere. Here we report a simple, low cost and potentially scalable mechanochemical procedure for the green synthesis of nanostructured h-AlN from a powder mixture of Aluminium and melamine precursors. A combination of experimental and theoretical techniques has been employed to provide comprehensive mechanistic insights on the reactivity of melamine, solid state metal-organic interactions and the structural transformation of Al to h-AlN under non-equilibrium ball milling conditions. The results reveal that melamine is adsorbed through the amine groups on the Aluminium surface due to the long-range van der Waals forces. The high energy provided by milling leads to the deammoniation of melamine at the initial stages followed by the polymerization and formation of a carbon nitride network, by the decomposition of the amine groups and, finally, by the subsequent diffusion of nitrogen into the Aluminium structure to form h-AlN.

The role of oxygen stoichiometry on phase stability, structure, and magnetic properties of Sr2CoIrO(6-δ).

The phase stability, crystal structure, and magnetic properties of perovskite-like nonstoichiometric Sr(2)CoIrO(6-δ) were studied. Oxygen deficiency can be well controlled and reversibly varied up to δ = 0.33. A single phase exists at least for partial oxygen pressures between 10(-5) and 1 bar at 1273 K, followed by phase decomposition at higher temperature with the elimination of metallic Ir and the formation of a new phase with approximately Sr(3)CoIrO(6) composition crystallizing in K(4)CdCl(6) structure type. The structural features of Sr(2)CoIrO(6-δ) are dependent on both temperature and oxygen content and were determined by synchrotron and neutron powder diffraction. Both the increasing amount of oxygen vacancies at constant temperature and increasing temperature at constant oxygen content result in the same higher crystal symmetry of Sr(2)CoIrO(6-δ): (1) The oxygen-stoichiometric phase Sr(2)CoIrO(6.00) is monoclinic (I2/m or P2(1)/n) at room temperature but cubic (Fm-3m) for Sr(2)CoIrO(5.67). (2) A sequence of phase transitions [Formula: see text] was observed for Sr(2)CoIrO(6.00) in air. All Sr(2)CoIrO(6-δ) compositions show weak ferromagnetism at low temperature with a canted but predominantly antiferromagnetic ground state. The magnetic ordering temperature decreases monotonously with increasing oxygen deficiency, while pronounced extrema are observed for the paramagnetic moment and the Curie-Weiss temperature at an oxygen deficiency δ ≈ 0.10, which corresponds to the P2(1)/n ↔ I2/m phase transformation.

Determination of manganese valency in La1-xSrxMnO3 using ELNES in the (S)TEM.

In this article several experimentally identified Mn valence-sensitive ELNES quantities for the La1-xSrxMnO3 compound class are presented, namely the energy separations between Mn-L3 and O-Ka, between O-Kb and O-Ka edges, the Mn-L2,3 white line intensity ratio, and the Mn-L3 line width. Valence sensitivities of these quantities are evaluated, and possible additional influences on them are considered. At high signal-to-noise ratio the two energy separations display most sensitively changes of the Mn valency. An experiment-based estimation of the total uncertainties of the quantities indicates that at low signal-to-noise ratio, which is the case when studying interface effects at high spatial resolution, again both energy separations allow to resolve the smallest valency changes.

Omega-conotoxin sensitivity and presynaptic inhibition of glutamatergic sensory neurotransmission in vitro.

Synaptic transmission between embryonic chick dorsal root ganglion (DRG) neurons and spinal cord neurons was studied in dissociated cell culture. Stimulation of DRG neurons evoked monosynaptic and polysynaptic excitatory responses in the spinal neurons. These responses could be reversibly blocked by application of 6-cyano-7-nitroquinoxaline-2,3-dione (a selective non-NMDA receptor antagonist) and irreversibly eliminated through the presynaptic action of omega-conotoxin GVIA (a selective N-type calcium channel antagonist). As N-type calcium channels in DRG neuron somata are targets for modulation via GABAB receptors, we tested the role of these receptors as regulators of synaptic transmission. Baclofen (a selective GABAB receptor agonist) reversibly inhibited synaptic transmission via a presynaptic, pertussis toxin-sensitive mechanism; CGP 35348 (a selective GABAB receptor antagonist) blocked the actions of baclofen. Taken together, these results demonstrate that N-type calcium channels play a dominant role in glutamatergic sensory neurotransmission. They suggest, in addition, that modulation of N-channel activity may underlie, at least in part, presynaptic inhibition of synaptic transmission between DRG neurons and their targets in the intact spinal cord.

Anisotropy in fitness landscapes.

A definition of empirical anisotropy is proposed, which allows for a quantitative measurement. This theory is applied to RNA free energy landscapes. It is shown that the biophysical GCAU landscapes are highly anisotropic, while the synthetic GCXK landscapes become isotropic for long chains. The major part of the anisotropy of the GCAU landscapes arises from the difference of the G identical to C and the A = U stacking parameters.

Multiple kinetic states underlying macroscopic M-currents in bullfrog sympathetic neurons.

M-current is a time- and voltage-dependent potassium current which is suppressible by muscarinic receptor activation. We have used curve fitting and noise analysis to determine if macroscopic M-currents deviate from a previously predicted simple two-state kinetic scheme. The M-current was best described by three kinetically distinct components: 'fast' (tau 0), 'intermediate' (tau 1) and 'slow' (tau 2) time constants. The 'fast' (tau 0) and 'intermediate' (tau 1) components were identified from the spectra of M-current noise at potentials positive to the cells' resting membrane potential. The 'intermediate' (tau 1) and 'slow' (tau 2) components were seen by curve fitting M-current deactivation currents. The 'intermediate' (tau 1) time constant was voltage dependent (decreasing e-fold in 23 mV), but voltage dependence of the 'fast' (tau 0) and 'slow' (tau 2) components was not obvious. All kinetic components were sensitive to muscarine, with the 'intermediate' (tau 1) and 'slow' (tau 2) being equally so. These data suggest that all components may derive from the same channel population, and that the M-channel may have at least four kinetic states.

[Psychiatry in a country hospital in Freudenstadt, close to the patients' domicile. A critical preliminary review after three years (author's transl)]. / Gemeindenahe Psychiatrie in Freudenstadt - kritische Zwischenbilanz nach 3 Jahren.

The article reports on the setting-up of a department of psychiatry at the general hospital in the Freudenstadt district. The department comprises 60 beds and represents the first hospital-integrated psychiatric department of its kind of the Baden-Württemberg Land government. It was inaugurated in the summer of 1976. The experience collected over a period of 3 years, presented here in detail, can be made use of within the overall framework of the discussions on the controversial issue of psychiatric departments in general hospitals, which has also been discussed on a political plane.

[The problem of juvenile alcoholism. An analysis of the literature (author's transl)]. / Zum Problem des Jugendalkoholismus. Eine Literaturanalyse

In contrast to drug addiction juvenile alcoholism now also common in West Germany, has hardly been investigated. This is meant to be an analysis of the literature, based mainly paper on German and American writings which the author tries to link to his own experience. The older papers from around the turn of the century are particularly evaluated. Essentially the following may be said: Transition between the use, misuse and dependence on alcohol is fluid, particularly in juvenile alcoholism. In our type of Society drinking in adolescence is part of an anticipatory socialization process and so a normal transitional phenomenon. More attention has lately been paid to influences arising in the primary group (family and peers). Girls tent to accept the traditions of the family more readily and follow in alcohol consumption more their mothers than their fathers. The epidemiologic papers published in German on drug addiction of juveniles can hardly be compared with each other, even if they take account of alcohol consumption. Individual control investigations on comparable populations during the last few years show an increase of excessive alcohol intake particularly among the young. In West Germany there are no reliable statistics on alcoholism in adults, even less in juveniles. The methodic difficulties in assessing prevalence of juvenile alcoholism are specific, but they mirror the general difficulties of definition in research into alcoholism. Clinical experience suggests that alcoholism runs a different course in juveniles--and in women--from that seen in adult men. Literature on juvenile alcoholism is sparse compared with that on drug addiction. The question of a correlation between primary alcoholism and drug-addiction - the role of alcohol as initiator to drugs - cannot be defined in general, only in individual terms. In drug addicts alcohol had and has the function of an addition to/or replecement for drugs. The alcohol problem started under the cover of drug addiction but without the preceding wave of drugs it would not have reached the present level...

[Exogenous psychosis in a patient with carcinoid syndrome following treatment with p-chlorophenylalanine (PCPA)]. / Exogene Psychose eines Patienten mit Karzinoidsyndrom nach Behandlung mit p-Chlorophenylalanin (PCPA)

A case is reported of a patient with carcinoid syndrome who developed a exogenous psychosis while under treatment with the serotonin-inhibitor p-chlorophenylalanine (PCPA). Partial symptoms similar to delirium and schizophrenia were exhibited. The attached literature survey focuses on the psychological side effects of PCPA treatment. A discussion follows concerning noteworthy phenomenological similarities between the case reported and certain forms of amphetamine psychosis. Common biochemical mechanisms are hypothetically stated.

Graduate Student Stipends: Greater reliance on the "traineeship" concept would facilitate a more purposeful and consistent treatment.

The situation of graduate students in physics is profoundly influenced by federal support, which has been applied with mixed, and occasionally contradictory, purpose. There are five important goals in the provision of graduate student stipends: (i) maintenance of "distinction for excellence"; (ii) rational distribution over scientific fields and subfields; (iii) constructive involvement of graduate students in undergraduate teaching; (iv) rational geographic and institutional distribution; and (v) administrative simplicity. These goals may be approached by making several adjustments of the present system. 1) The preeminence of individual predoctoral fellowships should be restored. They should be awarded sparingly to at most five percent of the graduate student population. 2) The great majority of stipends should take the form of traineeships. They should be assigned to departments according to rational criteria. 3) Research assistantships should be continued at a reduced level. Their maintenance will protect research activities of specific public interest when necessary. 4) Teaching should be incorporated into the normal responsibilities of fellows, trainees, and research assistants. Teaching assistance should be regarded as a budgeting category and not as an identifying characteristic of a particular group of students.