ABSTRACT
The experiments on white outbred awaken male rats have shown that derivatives of adamant-2-ylamides of alkylamidocarbonic acids exhibit prominent antiarrhythmic (antifibrillatory) effect on the model of calcium chloride arrhythmia. The most pronounced effect was demonstrated by N-[2(adamant-2-yl)aminocarbonylmethyl]-N'-[3-(diethylamino)propyl]-4-nitrobenzamide. This compound was also active on the model of aconitine arrhythmia, which is characteristic of class-I antiarrhythmic agents. It is established that N-[2-(adamant-2-yl)aminocarbonylmethyl]-N'-[3-(diethylamino)propyl]-4-nitrobenzamide has prominent antiarrhythmic activity and is more safe than other antiarrhythmic drugs of class I (lidocaine, ethmosine, novocainamide), class IV (verapamil), and class III (cardiocyclide).
Subject(s)
Adamantane/analogs & derivatives , Adamantane/pharmacology , Anti-Arrhythmia Agents/pharmacology , Arrhythmias, Cardiac/drug therapy , Benzamides/pharmacology , Aconitine/adverse effects , Aconitine/pharmacology , Adamantane/chemistry , Animals , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/physiopathology , Benzamides/chemistry , Male , Rats , Voltage-Gated Sodium Channel Agonists/adverse effects , Voltage-Gated Sodium Channel Agonists/pharmacologyABSTRACT
Afobazole pharmacokinetics upon oral administration of tablets prepared according to various technologies was studied in rabbits. The main pharmacokinetic parameters were determined.
