Subject(s)
Furaldehyde/poisoning , Liver/pathology , Acid Phosphatase/metabolism , Adenosine , Adenosine Triphosphatases/metabolism , Animals , Enzyme Induction , Glucosephosphate Dehydrogenase/metabolism , Glucosephosphates , Liver/drug effects , Liver/enzymology , Male , NAD , NADH Tetrazolium Reductase/metabolism , Phenobarbital/pharmacology , Rats , Succinate Dehydrogenase/metabolism , SuccinatesSubject(s)
Furaldehyde/poisoning , Kidney/pathology , Animals , Chronic Disease , Histocytochemistry , Kidney/enzymology , Male , RatsABSTRACT
The investigations were performed on mice. They were divided into a control group and 4 experimental groups. The experimental animals were administered intraperitoneally benzene 6 X every 24 h. The animals were decapitated 30 min. 4, 12 and 24 h after the last benzene administration. During the experiment, dyeing for neutral lipids and glycogen was carried out, and the activity of NADH2-r.t., SDH, G-6-Pase, ATP-ase and ACP was estimated. A decrease of glycogen content in liver cells, deviations in the amount of neutral lipids, reversible decrease of mitochondrial enzymes activity, and intensification of the processes of intracellular catabolism were found.
Subject(s)
Benzene/poisoning , Liver/drug effects , Acid Phosphatase/metabolism , Adenosine Triphosphatases/metabolism , Animals , Benzene/metabolism , Biotransformation , Glucose-6-Phosphatase/metabolism , Lipid Metabolism , Liver/enzymology , Liver/metabolism , Liver Glycogen/metabolism , Mice , NADH Tetrazolium Reductase/metabolism , Succinate Dehydrogenase/metabolismSubject(s)
Estrogens/pharmacology , Mouth Mucosa/drug effects , Animals , Castration , Epithelium/drug effects , Female , MiceSubject(s)
Endometrium/enzymology , Estrogens/pharmacology , Oxidoreductases/metabolism , Animals , Endometrium/drug effects , Female , RatsABSTRACT
The experiments were carried out on male Wistar-Rats. They were divided into 2 groups. The rats of the control groups were treated to Phenobarbital intraperitoneally for 3 consecutive days. The animals of the experimental group were additionaly injected with Benzen intraperitoneally on the 4th day of experiment. It has been found that Phenobarbital brought about the formation of 2 types of bright and dark cells in the liver. The action of Phenobarbital is carried on by Benzene. The authors discuss morphological and functional evaluation of bright and dark cells from the point of view of stimulating action of Phenobarbital as well as the course of Benzene biotransformation in liver cells.
Subject(s)
Benzene/poisoning , Chemical and Drug Induced Liver Injury/enzymology , Phenobarbital/pharmacology , Adenosine Triphosphatases/analysis , Animals , Benzene/metabolism , Chemical and Drug Induced Liver Injury/pathology , Endoplasmic Reticulum/ultrastructure , Glucose-6-Phosphatase/analysis , Histocytochemistry , Liver/enzymology , Liver/ultrastructure , Male , NADH Tetrazolium Reductase/analysis , Rats , Stimulation, ChemicalABSTRACT
The experiments were carried out on dogs. Experimental animals were subjected to the trauma of the thorax during operation. The localization and activity of succinic dehydrogenase, NADH2-tetrazole reductase, adenosine triphosphatase, alkaline and acid phosphates in the kidneys were examined. An increase of the activity of all the investigated enzymes takes place under the influence of the stress. On the basis of the investigations it can be supposed that the processes of oxygen phosphorylation and active transport are intensified. An increase of the activity of acid phosphates gives evidence of the intensity of phagocytosis and pinocytosis processes in the kidney.
