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Invasive characteristics of apathogenic Shigella flexneri 5a2c mutant obtained under the effect of furazolidone.
Efremova, T N; Gruzdeva, I G; Matveev, I V; Bozhokina, E S; Komissarchuk, Ya Yu; Fedorova, Z F; Khaitlina, S Yu.
Bull Exp Biol Med ; 137(5): 479-82, 2004 May.
Article in English | MEDLINE | ID: mdl-15455123

ABSTRACT

Apathogenic Shigella flexneri 5a2c mutant treated with furazolidone can infect eucaryotic cells. These bacteria contain no virulence genes responsible for Sh. flexneri invasion, which seems to be the cause of their apathogenicity. The capacity of bacteria to penetrate into eucaryotic cells correlates with the appearance of ECP 32 protease specifically cleaving actin.


Subject(s)
Furazolidone/pharmacology , Mutation/genetics , Shigella flexneri/genetics , Shigella flexneri/pathogenicity , Virulence Factors/genetics , Antigens, Bacterial/genetics , Cell Line, Tumor , DNA, Bacterial/analysis , DNA, Bacterial/genetics , Dysentery, Bacillary/drug therapy , Endopeptidases/analysis , Endopeptidases/physiology , Furazolidone/therapeutic use , Genes, Bacterial/genetics , Humans , Intracellular Space/microbiology , Plasmids/genetics , Shigella flexneri/drug effects
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