Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Central Nervous System Neoplasms/secondary , Orbital Neoplasms/drug therapy , Retinoblastoma/drug therapy , Central Nervous System Neoplasms/prevention & control , Child, Preschool , Chlorambucil/administration & dosage , Etoposide/administration & dosage , Humans , Male , Prednisolone/administration & dosage , Retinoblastoma/secondary , Risk Factors , Vincristine/administration & dosageABSTRACT
In a 15-year-old girl with right upper arm tumor diagnosed at first as neuroblastoma, the second histopathological examination revealed PNET. In spite of the advanced stage of disease (IIIrd or IVth) surgical excision was not performed but chemotherapy (8 courses of VADRAC and 8 courses of VP16 + CDDP) and radiotherapy (40 Gy) was administered. After 4 initial cycles all symptoms of the disease disappeared. The child remains in CCR for 60 months, including 40 months of therapy.
Subject(s)
Arm , Neuroectodermal Tumors, Primitive, Peripheral/therapy , Adolescent , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cisplatin/administration & dosage , Combined Modality Therapy , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Etoposide/administration & dosage , Female , Humans , Neuroectodermal Tumors, Primitive, Peripheral/diagnosis , Radiotherapy Dosage , Vincristine/administration & dosageABSTRACT
Analysis was made of ALL treatment results according program POG 8493 in 9 infants. In 4 children WBC exceeded 100.0 G/l, and in 5 children CNS was affected. Eight infants had remission, six had relapse (mainly BM): early up to 8 month in 5, late--in 52 month in one girl. Four children died after relapse, four are still living: 2 I RC (2 and 23 months), 2 in II RC (1 month and 23 month). Probability of 4-year EFS was 0.25 and that survival--0.44. In view of continuing poor ALL prognosis, in infants it is necessary to look for more effective methods of treatment.
