Acupuncture treatment for anti-NMDAR encephalitis: A case report.

RATIONALE: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a rare disease and common type of autoimmune encephalitis. The prognosis of patients with comorbid disorders of consciousness is poor, and no such acupuncture treatment has been reported. We report a case of acupuncture in anti-NMDAR encephalitis with a high cerebrospinal fluid titer combined with impaired consciousness. PATIENT CONCERNS: A 13-year-old girl with anti-NMDAR encephalitis presented to our hospital with impaired consciousness. DIAGNOSES: Therefore, the patient was diagnosed with anti-NMDAR encephalitis. According to the Chinese medicine theory, the diagnosis was Shenhun(phlegm obstructs the clear orifices). INTERVENTIONS: Depending on the patient's condition, we used the Xingnao Kaiqiao acupuncture therapeutic method. OUTCOMES: After 16 weeks of acupuncture treatment, the patient awoke and resumed a normal life with no recurrence at one-year follow-up. CONCLUSION: This case demonstrated that acupuncture can be used as a complementary and alternative treatment for anti-NMDAR encephalitis.

Capture and Utilization of CO2 with Morpholine for Effective Photocatalytic N-Formylmorpholine Production.

Converting into high-value-added products represents the most optimal approach to CO2 utilization. The substitution of CO with CO2 as a potential critical material for formamide production is widely regarded as an ideal pathway and has garnered significant attention. However, high temperatures and pressures remain essential for the reaction, exerting a substantial influence on the utilization process. Herein, N-formylmorpholine was creatively synthesized by integrating the capture and solar-driven utilization of CO2 with morpholine. Notably, a remarkable N-formylmorpholine yield of 11433.3 µmol·h-1·g-1 was obtained, surpassing pure MoO3 by an astounding factor of 89.1 with a N-formylmorpholine yield of 63.8 µmol in 6 h, which is an astonishing increase of 57.5 times compared to MoO3. Both experimental results and density functional theory calculations suggest that the inclusion of Fe can effectively reduce the formation energy barrier while facilitating the desorption process of N-formylmorpholine, thereby optimizing the overall performance.

Pulsed Electrocatalysis Enabling High Overall Nitrogen Fixation Performance for Atomically Dispersed Fe on TiO2.

Atomically dispersed Fe was designed on TiO2 and explored as a Janus electrocatalyst for both nitrogen oxidation reaction (NOR) and nitrogen reduction reaction (NRR) in a two-electrode system. Pulsed electrochemical catalysis (PE) was firstly involved to inhibit the competitive hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Excitingly, an unanticipated yield of 7055.81 µmol h-1 g-1 cat. and 12 868.33 µmol h-1 g-1 cat. were obtained for NOR and NRR at 3.5 V, respectively, 44.94 times and 7.8 times increase in FE than the conventional constant voltage electrocatalytic method. Experiments and density functional theory (DFT) calculations revealed that the single-atom Fe could stabilize the oxygen vacancy, lower the energy barrier for the vital rupture of N≡N, and result in enhanced N2 fixation performance. More importantly, PE could effectively enhance the N2 supply by reducing competitive O2 and H2 agglomeration, inhibit the electrocatalytic by-product formation for longstanding *OOH and *H intermediates, and promote the non-electrocatalytic process of N2 activation.

Role of whey protein in post-workout recovery / Função da proteína de soro de leite na recuperação pós-treino / El papel de la proteína de suero de leche en la recuperación post-entrenamiento

ABSTRACT Introduction: Evidence indicates that whey protein supplementation may accelerate tissue repair and be useful for exercise-induced muscle injury (EIMD) by accelerating recovery and elevating protein synthesis and blood amino acids. However, the potential role of whey protein after EIMD in humans is inconsistent. Objective: Find the effective role of whey protein in post-exercise recovery from EIMD. Methods: Scopus, Medline, and Google scholar, were systematically searched until March 2022. To assess the risk of bias, the Cochrane collaboration tool was applied. Weighted mean differences (WMD), 95% confidence intervals (CI), and random effect models to calculate the total effect. Results: The result of the review indicated that the decreasing impact of whey protein intake is significant on creatine kinase (CK) [WMD = −19.11 IU.L-1, CI: −36.200, −2.036; P = 0.028]. The effect of whey protein supplementation on lactate dehydrogenase (LDH) concentration indicated that the impact of whey protein on changing LDH levels is significant. In addition, subgroup analysis showed significant decreases in CK and LDH based on post-exercise follow-up times, whey protein dosage, test duration, supplementation time, exercise types, and training status. Conclusion: The results showed the efficacy of whey protein in decreasing CK and LDH levels among adults in general and in subgroup analysis. Therefore, whey protein could have an effective role in the post-exercise recovery of EIMD. Level of evidence II; Therapeutic studies - review of results.

RESUMO Introdução: As evidências indicam que a suplementação de proteína de soro de leite pode acelerar a reparação tecidual e, portanto, ser útil para as lesões musculares induzidas pelo exercício (EIMD), acelerando a recuperação, além de elevar a síntese proteica e os aminoácidos sanguíneos. Entretanto, o papel potencial da proteína de soro de leite após a EIMD em humanos, é inconsistente. Objetivos: Encontrar a função efetiva da proteína de soro de leite na recuperação pós exercício de EIMD. Métodos: Scopus, Medline e Google scholar foram sistematicamente pesquisados até março de 2022. Para avaliar o risco de viés, foi aplicada a ferramenta de colaboração Cochrane. Diferenças médias ponderadas (WMD), intervalos de confiança de 95% (CI) e modelos de efeito aleatório foram utilizados para o cálculo do efeito total. Resultados: O resultado da revisão indicou que o impacto decrescente do consumo de proteína de soro de leite é significativo na creatina quinase (CK) [WMD = −19,11 IU.L-1, CI: −36,200, −2,036; P = 0,028]. O efeito da suplementação proteica do soro de leite na concentração de desidrogenase láctica (LDH) indicou que o impacto da proteína do soro de leite na mudança dos níveis de LDH é significativo. Além disso, a análise dos subgrupos mostrou diminuição significativa na CK e LDH, com base nos tempos de acompanhamento após o exercício, dosagem da proteína do soro de leite, duração dos testes, tempo de suplementação, tipos de exercício e status de treinamento. Conclusão: Os resultados mostraram a eficácia da proteína de soro de leite na diminuição dos níveis de CK e LDH entre adultos, em geral e na análise dos subgrupos. Portanto, a proteína do soro de leite poderia ter uma função eficaz na recuperação pós exercício de EIMD. Nível de evidência II; Estudos terapêuticos - revisão dos resultados.

RESUMEN Introducción: Las pruebas indican que la suplementación con proteína de suero de leche puede acelerar la reparación de los tejidos y, por lo tanto, ser útil para las lesiones musculares inducidas por el ejercicio (EIMD) al acelerar la recuperación, así como elevar la síntesis de proteínas y los aminoácidos en sangre. Sin embargo, el papel potencial de la proteína de suero después de la EIMD en los seres humanos, es inconsistente. Objetivos: Encontrar el papel efectivo de la proteína de suero de leche en la recuperación posterior al ejercicio de EIMD. Métodos: Se realizaron búsquedas sistemáticas en Scopus, Medline y Google scholar hasta marzo de 2022. Para evaluar el riesgo de sesgo, se aplicó la herramienta de colaboración Cochrane. Para calcular el efecto total se utilizaron diferencias medias ponderadas (WMD), intervalos de confianza (CI) del 95% y modelos de efectos aleatorios. Resultados: El resultado de la revisión indicó que el impacto decreciente de la ingesta de proteína de suero es significativo en la creatina quinasa (CK) [WMD = −19,11 UI.L-1, IC: −36,200, −2,036; P = 0,028]. El efecto de la suplementación con proteína de suero en la concentración de lactato deshidrogenasa (LDH) indicó que el impacto de la proteína de suero en el cambio de los niveles de LDH es significativo. Además, el análisis de subgrupos mostró disminuciones significativas de la CK y la LDH en función de los tiempos de seguimiento tras el ejercicio, la dosis de proteína de suero, la duración de la prueba, el tiempo de suplementación, los tipos de ejercicio y el estado de entrenamiento. Conclusión: Los resultados mostraron la eficacia de la proteína de suero en la disminución de los niveles de CK y LDH entre los adultos en general y en el análisis de subgrupos. Por lo tanto, la proteína de suero podría tener un papel eficaz en la recuperación posterior al ejercicio de EIMD. Nivel de evidencia II; Estudios terapéuticos - revisión de resultados.

An evaluation of the effectiveness of acupuncture with seven acupoint-penetrating needles on cervical spondylosis.

Objective: To investigate the clinical efficacy of acupuncture with seven acupoint-penetrating needles on patients with cervical spondylosis. Patients and methods: Sixty patients with cervical spondylosis were grouped using computer-generated random numbers. Group A (n=30) received acupuncture with seven acupoint-penetrating needles combined with traction. Group B (n=30) received acupuncture of non-relevant acupuncture points combined with traction. Clinical efficacy and changes in the Visual Analogue Scale (VAS), Neck Disability Index (NDI), and Pittsburgh Sleep Quality Index (PSQI) scores in the two groups were compared. Results: The total effective rate was significantly higher in group A (90.0%) than in group B (76.6%) (P<0.05). The VAS, NDI, and PSQI scores of the two groups after treatment were significantly lower than scores before treatment (P<0.05). After treatment, the NDI and PSQI scores of group A were significantly lower than those in group B (P<0.05). Conclusion: Acupuncture using seven acupoint-penetrating needles combined with traction was more effective, reduced neck pain, and improved sleep quality in patients with cervical spondylosis compared to acupuncture of non-relevant acupuncture points.