ABSTRACT
Extensive burns can cause nonnegligible acute and chronic damage to central nervous system of patients. The damage of central nervous system may have a profound impact on patients, including neurobehavioral changes such as post-traumatic stress disorder, depression, anxiety, and sleep disorder. These changes may persist after injury, greatly affecting patients' integration into society and return to work. This paper systematically reviewed the clinical manifestations, pathogenesis, and current intervention methods of mental disorders in patients with extensive burns, aiming to provide a basis for further understanding, prevention, and treatment of patients with mental disorders after burns.
Subject(s)
Burns , Stress Disorders, Post-Traumatic , Humans , Anxiety , Stress Disorders, Post-Traumatic/etiology , Stress Disorders, Post-Traumatic/prevention & control , Anxiety Disorders/complications , Burns/complications , Burns/therapy , Burns/pathologyABSTRACT
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Subject(s)
Leukemia, Promyelocytic, Acute , Apoptosis , Cell Differentiation , Cell Line, Tumor , Humans , RNA, Long Noncoding , TretinoinABSTRACT
Liver fibrosis is a common pathological response in chronic liver injury. In the pathological process of hepatic injury, signaling pathways associated with hepatic fibrosis, which mediates the repair, proliferation and fibrosis of the liver secrete different cytokines. In these pathways, transforming growth factor beta (TGFß) and signal transducer and activator of transcription 3 (STAT3) play key roles in the proliferation and activation of hepatic stellate cells (HSCs) and promote epithelial mesenchymal transition. In addition, it is also involved in the process of proliferation and transformation of collagen and extracellular matrix molecules into myofibroblasts. TGFß and STAT3 molecular-related signaling pathways mediate the loss of epithelial phenotype and gene expression in mature epithelial cells, transforming them into mesenchymal cells, and producing anti-apoptosis to hepatocytes and promoting the proliferation of HSCs. However, the mechanisms by which STAT3 and TGFß molecules are involved in the development and progression of liver fibrosis are not sound distinct. In this review, we attempt to know the mechanisms and interactions of TGFß and STAT3 molecules that mediate potential liver fibrosis, and promote their role in promoting HSCs production and epithelial mesenchymal transition.
Subject(s)
Hepatic Stellate Cells , Liver Cirrhosis/diagnosis , STAT3 Transcription Factor , Transforming Growth Factor beta , Humans , Liver , Transforming Growth Factor beta1ABSTRACT
Recently a new diluted magnetic semiconductor, (Ba,K)(Zn,Mn)2As2 (BZA), with high Curie temperature was discovered, showing an independent spin and charge-doping mechanism. This makes BZA a promising material for spintronics devices. We report the successful growth of a BZA single crystal for the first time in this study. An Andreev reflection junction, which can be used to evaluate spin polarization, was fabricated based on the BZA single crystal. A 66% spin polarization of the BZA single crystal was obtained by Andreev reflection spectroscopy analysis.
ABSTRACT
OBJECTIVE: The aim of this study was to investigate the correlation of twisting motion phase and infantile spasms in high risk infants. MATERIALS AND METHODS: One hundred seventy-eight high-risk newborns experiencing follow-up in the rehabilitation phase were selected and full-body motion quality assessment was performed in the twisting motion phase. The occurrence of infants with infantile spasms after 12 months (corrected age) was statistically analyzed. RESULTS: No clear correlation was found between monotonous movement twisting motion phase and infantile spasms, and spasm synchronized movement had no definite prediction for infantile spasms. The incidence of infant spasm with movement form having spastic synchronized characteristics had significant difference compared with monotonous systemic movement (p < 0.01). The sensitivity of predictive rate for spasm-synchronous movement of infantile spasms was 90.9%, the specificity was 96.8%, the positive predictive value was 80%, and the negative predictive value was 98.7%. CONCLUSIONS: Spasm synchronized movement had some predictive value for infantile spasms in twisting motion stage. The newborns with this kind of movement form should be checked by regularly ambulatory EEG.
