ABSTRACT
Purpose: The lack of finely annotated pathologic data has limited the application of deep learning systems (DLS) to the automated interpretation of pathologic slides. Therefore, this study develops a robust self-supervised learning (SSL) pathology diagnostic system to automatically detect malignant melanoma (MM) in the eyelid with limited annotation. Design: Development of a self-supervised diagnosis pipeline based on a public dataset, then refined and tested on a private, real-world clinical dataset. Subjects: A. Patchcamelyon (PCam)-a publicly accessible dataset for the classification task of patch-level histopathologic images. B. The Second Affiliated Hospital, Zhejiang University School of Medicine (ZJU-2) dataset - 524,307 patches (small sections cut from pathologic slide images) from 192 H&E-stained whole-slide-images (WSIs); only 72 WSIs were labeled by pathologists. Methods: Patchcamelyon was used to select a convolutional neural network (CNN) as the backbone for our SSL-based model. This model was further developed in the ZJU-2 dataset for patch-level classification with both labeled and unlabeled images to test its diagnosis ability. Then the algorithm retrieved information based on patch-level prediction to generate WSI-level classification results using random forest. A heatmap was computed for visualizing the decision-making process. Main outcome measures: The area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity were used to evaluate the performance of the algorithm in identifying MM. Results: ResNet50 was selected as the backbone of the SSL-based model using the PCam dataset. This algorithm then achieved an AUC of 0.981 with an accuracy, sensitivity, and specificity of 90.9, 85.2, and 96.3% for the patch-level classification of the ZJU-2 dataset. For WSI-level diagnosis, the AUC, accuracy, sensitivity, and specificity were 0.974, 93.8%, 75.0%, and 100%, separately. For every WSI, a heatmap was generated based on the malignancy probability. Conclusion: Our diagnostic system, which is based on SSL and trained with a dataset of limited annotation, can automatically identify MM in pathologic slides and highlight MM areas in WSIs by a probabilistic heatmap. In addition, this labor-saving and cost-efficient model has the potential to be refined to help diagnose other ophthalmic and non-ophthalmic malignancies.
ABSTRACT
A key challenge in the task of human pose and shape estimation is occlusion, including self-occlusions, object-human occlusions, and inter-person occlusions. The lack of diverse and accurate pose and shape training data becomes a major bottleneck, especially for scenes with occlusions in the wild. In this paper, we focus on the estimation of human pose and shape in the case of inter-person occlusions, while also handling object-human occlusions and self-occlusion. We propose a novel framework that synthesizes occlusion-aware silhouette and 2D keypoints data and directly regress to the SMPL pose and shape parameters. A neural 3D mesh renderer is exploited to enable silhouette supervision on the fly, which contributes to great improvements in shape estimation. In addition, keypoints-and-silhouette-driven training data in panoramic viewpoints are synthesized to compensate for the lack of viewpoint diversity in any existing dataset. Experimental results show that we are among the state-of-the-art on the 3DPW and 3DPW-Crowd datasets in terms of pose estimation accuracy. The proposed method evidently outperforms Mesh Transformer, 3DCrowdNet and ROMP in terms of shape estimation. Top performance is also achieved on SSP-3D in terms of shape prediction accuracy. Demo and code will be available at https://igame-lab.github.io/LASOR/.
