Subject(s)
Blood Platelets , Factor VIIa , Endothelial Protein C Receptor , Humans , Protein C , Receptors, Cell SurfaceSubject(s)
Dermatitis, Atopic/drug therapy , Drugs, Chinese Herbal/administration & dosage , Administration, Cutaneous , Administration, Oral , Adolescent , Child , Dermatitis, Atopic/diagnosis , Drug Therapy, Combination/methods , Drugs, Chinese Herbal/adverse effects , Feasibility Studies , Female , Follow-Up Studies , Glucocorticoids/administration & dosage , Humans , Male , Pilot Projects , Quality of Life , Severity of Illness Index , Skin Cream/administration & dosage , Treatment OutcomeABSTRACT
Twelve Mannich bases containing alpha, beta-unsaturated ketone were synthesized and characterized by elemental analysis, IR, 1HNMR, UV and MS spectra. All of the title compounds were unreported in the literature, some of these compounds showed marked antibacterial activity.
Subject(s)
Anti-Infective Agents/chemical synthesis , Mannich Bases/chemical synthesis , Anti-Bacterial Agents , Anti-Infective Agents/pharmacology , Aspergillus/drug effects , Epidermophyton/drug effects , Mannich Bases/pharmacology , Streptococcus/drug effectsABSTRACT
Using tissue culture and biochemical technique, the effects of autacoid-histamine and histamine H-2 receptor's antagonist-cimetidine on human lung cancer cell line were studied. It was shown that histamine at the concentration of 1.8 x 10(-7) M stimulated proliferation of the lung cancer cells, but histamine at the concentration of 1.8 x 10(-4) M or cimetidine at 1.76 x 10(-7) M inhibited growth of the lung cancer cells. Relation between histamine, histidine decarboxylase, histamine formation capacity and tumor proliferation is discussed.
