ABSTRACT
Medical confidentiality is sometimes difficult to impose on patient's families, especially in the field of oncology. Here, we describe the case of a 54-years-old woman with a T1N0M0 lung adenocarcinoma. After the diagnosis was made, she advised the medical team not to inform her family about her disease. Although the patient was aware of the high-risk of relapse, she was lost of follow-up after first-line treatment. Five years later, she presented with multi-metastatic recurrence and had to be admitted in an intensive-care unit for severe respiratory failure due to tumor progression. She kept refusing to inform her family, which in the end was contacted by the patient's sister, a few hours before her death. This observation highlights the absolute inviolability of medical confidentiality and led the French Association of Young Pneumologist to initiate a multi-disciplinary symposium on ethical problems raised by the management of patients with lung cancer.
Subject(s)
Adenocarcinoma , Confidentiality , Family , Lung Neoplasms , Adenocarcinoma/pathology , Adenocarcinoma/secondary , Adenocarcinoma/therapy , Disease Progression , Fatal Outcome , Female , Humans , Lung Neoplasms/complications , Lung Neoplasms/pathology , Lung Neoplasms/therapy , Middle Aged , Respiratory Insufficiency/etiologyABSTRACT
Bronchioloalveolar carcinoma (BAC) and adenocarcinoma mixed subtype with bronchioloalveolar features (ADC-WBF) represent a unique anatomo-clinical entity accounting for some 20% of non-small cell lung cancers (NSCLC). These tumors seem less sensitive to chemotherapy than other NSCLC. We report two cases of advanced ADC-WBF treated with second-line and fourth-line pemetrexed. Major and durable radiological response associated with clinical and functional improvement was achieved in both patients, without important drug toxicity. After treatment arrest, the two patients experienced progressive disease but responded to retreatment with pemetrexed. Recent data suggest that paclitaxel-based chemotherapy and epidermal growth factor receptor tyrosine kinase inhibitors could be an acceptable therapeutic strategy in unresectable CBA and ADC-WBF. The cases reported here and preclinical findings suggest a therapeutic efficacy of pemetrexed in these tumors. Prospective studies are required to evaluate this hypothesis.
Subject(s)
Adenocarcinoma, Bronchiolo-Alveolar/drug therapy , Adenocarcinoma/drug therapy , Adenocarcinoma/pathology , Antimetabolites, Antineoplastic/therapeutic use , Bone Neoplasms/drug therapy , Bone Neoplasms/secondary , Glutamates/therapeutic use , Guanine/analogs & derivatives , Lung Neoplasms/drug therapy , Lung Neoplasms/pathology , Adenocarcinoma/diagnosis , Adenocarcinoma/physiopathology , Adenocarcinoma, Bronchiolo-Alveolar/diagnosis , Adenocarcinoma, Bronchiolo-Alveolar/pathology , Adenocarcinoma, Bronchiolo-Alveolar/physiopathology , Aged , Antimetabolites, Antineoplastic/adverse effects , Bone Neoplasms/diagnosis , Bone Neoplasms/physiopathology , Cough , Disease Progression , Dyspnea , Folic Acid/administration & dosage , Glutamates/adverse effects , Guanine/adverse effects , Guanine/therapeutic use , Humans , Lung Neoplasms/diagnosis , Lung Neoplasms/physiopathology , Male , Neoplasm Staging , Neutropenia , Pemetrexed , Remission Induction , Renal Insufficiency , Smoking , Tomography, X-Ray Computed , Vitamin B 12/administration & dosageABSTRACT
OBJECTIVES: To evaluate 3D Volumetric Interpolated Breath-hold Examination (VIBE) whole-body MRI (WB-MRI) acquisition for the metastases staging. METHODS: Thirty-two consecutive patients with solid tumor were examined from head to feet before and after contrast injection. An automatic subtraction occurred between the 2 series of images. WB-MRI was compared with conventional staging techniques (CT, scintigraphy, brain MRI, and whole-body PET in 4 cases). RESULTS: WB-MRI and the reference techniques depicted metastases in 25 patients. WB-MRI depicted more bone lesions in the spine, pelvis, skull, femur, and tibia, whereas scintigraphy detected more rib lesions. WB-MRI depicted 27 cerebral metastases, whereas brain MRI depicted 40 cerebral metastases. WB-MRI depicted a total of 8 hepatic metastases, 8 adrenal lesions, and conventional staging 7 hepatic metastases and 10 adrenal lesions. WB-MRI examination depicted lung metastases in 10 patients, and CT examination in 13 patients. CONCLUSION: The results of this study indicate that WB-MRI is a feasible and promising technique for tumor staging.
Subject(s)
Image Enhancement/methods , Imaging, Three-Dimensional/methods , Magnetic Resonance Imaging/methods , Neoplasm Metastasis/diagnosis , Whole Body Imaging , Adrenal Gland Neoplasms/diagnosis , Adrenal Gland Neoplasms/secondary , Adult , Aged , Bone Neoplasms/diagnosis , Bone Neoplasms/secondary , Brain Neoplasms/diagnosis , Brain Neoplasms/secondary , Breast Neoplasms/diagnosis , Colonic Neoplasms/diagnosis , Female , Humans , Liver Neoplasms/diagnosis , Liver Neoplasms/secondary , Lung Neoplasms/diagnosis , Lung Neoplasms/secondary , Lymphatic Metastasis , Male , Mass Screening , Middle Aged , Neoplasm Metastasis/pathology , Neoplasm Staging , Ovarian Neoplasms/diagnosis , Skin Neoplasms/diagnosis , Skin Neoplasms/secondary , Subtraction Technique , Tomography, X-Ray Computed/methods , Uterine Neoplasms/diagnosisABSTRACT
PURPOSE: To investigate variations of circulating serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and interleukin-10 (IL-10) during three-dimensional conformal radiation therapy (3D-CRT) in patients with non-small-cell lung cancer and correlate these variations with the occurrence of radiation pneumonitis. PATIENTS AND METHODS: Ninety-six patients receiving 3D-CRT for stage I to III disease were evaluated prospectively. Circulating cytokine levels were determined before, every 2 weeks during, and at the end of treatment. Radiation pneumonitis was evaluated prospectively between 6 and 8 weeks after 3D-CRT. The predictive value of clinical, dosimetric, and biologic (cytokine levels) factors was evaluated both in univariate and multivariate analyses. RESULTS: Forty patients (44%) experienced score 1 or more radiation pneumonitis. No association was found between baseline cytokine levels and the risk of radiation pneumonitis. In the whole population, mean levels of TNFalpha, IL-6, and IL-10 remained stable during radiotherapy. IL-6 levels were significantly higher (P = .047) during 3D-CRT in patients with radiation pneumonitis. In the multivariate analysis, covariations of IL-6 and IL-10 levels during the first 2 weeks of 3D-CRT were evidenced as independently predictive of radiation pneumonitis in this series (P = .011). CONCLUSION: Early variations of circulating IL-6 and IL-10 levels during 3D-CRT are significantly associated with the risk of radiation pneumonitis. Variations of circulating IL-6 and IL-10 levels during 3D-CRT may serve as independent predictive factors for this complication.
Subject(s)
Carcinoma, Non-Small-Cell Lung/radiotherapy , Interleukin-10/blood , Interleukin-6/blood , Lung Neoplasms/radiotherapy , Radiation Pneumonitis/blood , Radiotherapy, Conformal/methods , Adult , Aged , Biomarkers/blood , Carcinoma, Non-Small-Cell Lung/blood , Female , Follow-Up Studies , Humans , Lung Neoplasms/blood , Male , Middle Aged , Multivariate Analysis , Predictive Value of Tests , Prospective Studies , Radiation Pneumonitis/diagnosis , Radiation Pneumonitis/etiology , Radiotherapy, Conformal/adverse effects , Time Factors , Treatment Outcome , Tumor Necrosis Factor-alpha/metabolismABSTRACT
French blood banks recently implemented nucleic acid testing (NAT) of all blood donations to reduce the risk of HIV transmission during the pre-seroconversion period. For tissue donation, HIV infection screening relies on HIV p24 antigen and anti-HIV-1 and 2 antibody detection. In this report, two related cases of infectious donations are described from a cornea donor during the preseroconversion window who was infected by an HIV antibody and NAT negative blood donor. After investigation, the blood donor was found to be herself in the preseroconversion window. Two months after donation, she was found to be HIV positive. The residual risk of HIV infectious blood donations since NAT has been introduced is estimated to be lower than one out of 2.5 millions. Individual NAT instead of minipool testing would not increase significantly the blood transfusion safety. In contrast, introduction of NAT should be considered to increase tissue donation safety as soon as such screening will be possible technically.
Subject(s)
Blood Donors , Blood/virology , HIV Infections/diagnosis , HIV Infections/transmission , HIV-1 , Tissue Donors , Transplants/virology , Aged , Antibodies, Viral/blood , Base Sequence , Female , Genes, Viral , HIV Core Protein p24/analysis , HIV Infections/prevention & control , HIV Protease/genetics , HIV Reverse Transcriptase/genetics , HIV-1/genetics , HIV-1/immunology , HIV-1/isolation & purification , Humans , Molecular Sequence Data , RNA, Viral/blood , Sequence Alignment , Sequence Homology, Nucleic AcidABSTRACT
A 64-year-old man presented with a lung metastasis of the lower left lobe. After partial response with chemotherapy, a thoracotomy was performed that did not allow a wedge resection, and lobectomy was contraindicated by the patient's ventilatory function. Radiofrequency ablation of this lung metastasis was thus performed, followed by a delayed cavitation with no infection, which, to our knowledge, has not yet been described.
Subject(s)
Lung Neoplasms/secondary , Lung Neoplasms/surgery , Catheter Ablation , Humans , Male , Middle Aged , Thoracotomy , Treatment OutcomeABSTRACT
We report a case of an exogenous lipoid pneumonia that appeared as a spiculated calcified mass on CT scan in which a positron emission tomography (PET) scan was performed before histological analysis. The F-18 fluoro-deoxy-D-glucose (FDG) PET showed a pattern highly suggestive of malignancy which, to our knowledge, has not yet been described. Similar to inflammatory and infectious lung diseases, lipoid pneumonia may be a false-positive case of F-18 FDG uptake.
