1.
Pol J Vet Sci
; 21(2): 409-413, 2018 Jun.
Article
in English
| MEDLINE
| ID: mdl-30450884
ABSTRACT
Taking bacterial virulence factors as targets is a new therapy for treating host bacterial infection. The aim of this study was to investigate the effect of matrine on α-hemolysin production of Staphylococcus aureus (S. aureus) and reducing the damage to bovine mammary epithelial cells (BMECs) induced by S. aureus α-hemolysin. Subinhibitory concentrations of matrine decreased the production of α-hemolysin in none dose-dependent manner and matrine exhibited a protective effect on S. aureus-induced BMECs injury. The results indicated that the structure of matrine may potentially be used as a basic structure for development of drugs aimed at curing and preventing dairy bovine mastitis.
Subject(s)
Alkaloids , Epithelial Cells , Hemolysin Proteins , Quinolizines , Staphylococcal Infections , Staphylococcus aureus , Alkaloids/pharmacology , Animals , Cattle , Epithelial Cells/pathology , Female , Mastitis, Bovine , Quinolizines/pharmacology , Staphylococcal Infections/veterinary , Staphylococcus aureus/pathogenicity , Matrines
2.
J Eur Acad Dermatol Venereol
; 24(5): 611-2, 2010 May.
Article
in English
| MEDLINE
| ID: mdl-19793152