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Inorg Chem ; 48(11): 4637-9, 2009 Jun 01.
Article in English | MEDLINE | ID: mdl-19361162

ABSTRACT

Two novel DNA-intercalating ruthenium(II) complexes, [Ru(bpy)(2)(PIPSH)](2+) and [Ru(bpy)(2)(PIPNH)](2+), have been synthesized and characterized. Gel retardation assay, atomic force microscopy, and dynamic light scattering studies show that both complexes can induce the condensation of originally circular plasmid pBR322 DNA to particulate structures under neutral conditions.


Subject(s)
DNA/chemistry , Organometallic Compounds/chemistry , Electrophoresis, Agar Gel , Light , Microscopy, Atomic Force , Molecular Structure , Organometallic Compounds/chemical synthesis , Scattering, Radiation
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