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J Ethnopharmacol ; 20(1): 21-4, 1987 Jun.
Article in English | MEDLINE | ID: mdl-3626592

ABSTRACT

(+)-Gossypol has neither antifertility effect nor toxicity at the dosage of 30 mg/kg orally for 14 days in male rats, but slight damage was found in the germinal epithelium of the testis in animals dosed for 4 weeks. (-)-Gossypol at 30 mg/kg orally for 7 days clearly had an antifertility effect in male rats. It appears that (-)-gossypol is the active stereoisomer of racemic gossypol.


Subject(s)
Gossypol/toxicity , Infertility, Male/chemically induced , Animals , Male , Rats , Rats, Inbred Strains , Sperm Motility/drug effects , Stereoisomerism
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