Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells.

The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancer-origin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test (BSLT), the present results suggest the potential use of the B-serum sub-fractions in cancer treatment.

catena-Poly[[[aqua-manganese(III)]-µ-(E)-5-bromo-N-[2-(5-bromo-2-oxidobenzyl-idene-amino)-4-nitro-phen-yl]-2-oxidobenzamidato] N,N-dimethyl-fomamide monosolvate].

The asymmetric unit of the title complex, {[Mn(C(20)H(10)Br(2)N(3)O(5))(H(2)O)]·(CH(3))(2)NCHO}(n), consists of one Mn(III) ion, one (E)-5-bromo-N-[2-(5-bromo-2-oxidobenzyl-idene-amino)-4-nitro-phen-yl]-2-oxidobenzamidate ligand (Schiff base), one water mol-ecule and an N,N-dimethyl-formamide mol-ecule. The coordination geometry around the Mn(III) ion is a distorted octa-hedron, being surrounded by two O and two N atoms from the Schiff base, which are positioned in the equatorial plane. The water mol-ecule and the O atom of the carbonyl group from the adjacent Mn(III) complex are situated at the axial positions, leading to a polymeric chain along the c axis. In the crystal, the complex and N,N-dimethyl-formamide mol-ecules are connected via O-H⋯O, C-H⋯O and C-H⋯Br hydrogen bonds, forming a three-dimensional network.

N-(4-Chloro-benzyl-idene)-4-nitro-benzene-1,2-diamine.

In the title compound, C(13)H(10)ClN(3)O(2), the dihedral angle between the two benzene rings is 3.61 (6)°. In the crystal structure, mol-ecules are linked by weak inter-molecular C-H⋯O hydrogen bonds, forming layers parallel to the bc plane. Short inter-molecular Cl⋯Cl contacts [3.491 (1) Å] are also observed.

2-[(E)-(3-Carb-oxy-4-hy-droxy-phen-yl)iminiometh-yl]-4-chloro-phenolate.

The title Schiff base compound, C(14)H(10)ClNO(4), has been synthesized by the reaction of 5-amino-2-hy-droxy-benzoic acid and 5-chloro-2-hy-droxy-benzaldehyde. The mol-ecule is a zwitterion in the crystal, with the phenolic hy-droxy group deprotonated and the imine N atom protonated. It adopts an E configuration about the central C=N double bond. The dihedral angle between the two benzene rings is 3.83 (7)°. Intra-molecular N-H⋯O and O-H⋯O hydrogen bonding generates S(6) ring motifs. In the crystal, mol-ecules are connected by inter-molecular O-H⋯O and C-H⋯Cl hydrogen bonds, forming a supra-molecular chain.