ABSTRACT
The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancer-origin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test (BSLT), the present results suggest the potential use of the B-serum sub-fractions in cancer treatment.
Subject(s)
Breast/drug effects , Cell Proliferation/drug effects , Epithelial Cells/drug effects , Hevea/chemistry , Latex/pharmacology , Animals , Artemia/drug effects , Breast/cytology , Cell Line, Tumor , Female , Humans , Latex/toxicityABSTRACT
The asymmetric unit of the title complex, {[Mn(C(20)H(10)Br(2)N(3)O(5))(H(2)O)]·(CH(3))(2)NCHO}(n), consists of one Mn(III) ion, one (E)-5-bromo-N-[2-(5-bromo-2-oxidobenzyl-idene-amino)-4-nitro-phen-yl]-2-oxidobenzamidate ligand (Schiff base), one water mol-ecule and an N,N-dimethyl-formamide mol-ecule. The coordination geometry around the Mn(III) ion is a distorted octa-hedron, being surrounded by two O and two N atoms from the Schiff base, which are positioned in the equatorial plane. The water mol-ecule and the O atom of the carbonyl group from the adjacent Mn(III) complex are situated at the axial positions, leading to a polymeric chain along the c axis. In the crystal, the complex and N,N-dimethyl-formamide mol-ecules are connected via O-Hâ¯O, C-Hâ¯O and C-Hâ¯Br hydrogen bonds, forming a three-dimensional network.
ABSTRACT
In the title compound, C(13)H(10)ClN(3)O(2), the dihedral angle between the two benzene rings is 3.61â (6)°. In the crystal structure, mol-ecules are linked by weak inter-molecular C-Hâ¯O hydrogen bonds, forming layers parallel to the bc plane. Short inter-molecular Clâ¯Cl contacts [3.491â (1)â Å] are also observed.
ABSTRACT
The title Schiff base compound, C(14)H(10)ClNO(4), has been synthesized by the reaction of 5-amino-2-hy-droxy-benzoic acid and 5-chloro-2-hy-droxy-benzaldehyde. The mol-ecule is a zwitterion in the crystal, with the phenolic hy-droxy group deprotonated and the imine N atom protonated. It adopts an E configuration about the central C=N double bond. The dihedral angle between the two benzene rings is 3.83â (7)°. Intra-molecular N-Hâ¯O and O-Hâ¯O hydrogen bonding generates S(6) ring motifs. In the crystal, mol-ecules are connected by inter-molecular O-Hâ¯O and C-Hâ¯Cl hydrogen bonds, forming a supra-molecular chain.