ABSTRACT
OBJECTIVE: To investigate the genetic polymorphism of human complement components C(4) and Bf and their complotype frequencies in Chinese Han population in Guangdong Province of China. METHODS: The genetic polymorphisms and complotypes of Bf, C(4)A and C(4)B, which were 3 components of HLA-III, were analyzed in 144 chromosomes of subjects from healthy Han families in Guangdong Province. RESULTS: Thirteen variable complotypes were identified, led by the complotypes of S(32), S(31), S(42) and F(42) among which strong linkage disequilibria were observed. The most common phenotypes were BFS, C(4)A(3), C(4)A(4), C(4)B(2) and C(4)B(1). CONCLUSION: The genetic polymorphism of C(4) and Bf and their complotypes have their own genetic predisposition in Chinese Han population in Guangdong Province.
