Diffusion-weighted imaging does not seem to be a predictor of consistency in pituitary adenomas.

PURPOSE: To prospectively evaluate the usefulness of T1-weighted imaging (T1WI) and diffusion-weighted imaging (DWI) sequences in predicting the consistency of macroadenomas. In addition, to determine their values ​​as prognostic factors of surgical outcomes. METHODS: Patients with pituitary macroadenoma and surgical indication were included. All patients underwent pre-surgical magnetic resonance imaging (MRI) that included the sequences T1WI before and after contrast administration and DWI with the apparent diffusion coefficient (ADC) map. Post-surgical MRI was performed at least 3 months after surgery. The consistency of the macroadenomas was evaluated at surgery, and they were grouped into soft and intermediate/hard adenomas. Mean ADC values, signal on T1WI and the ratio of tumor ADC values ​​to pons (ADCR) were compared with tumor consistency and grade of surgical resection. RESULTS: A total of 80 patients were included. A softened consistency was found at surgery in 53 patients and hardened in 27 patients. The median ADC in the soft consistency group was 0.532 × 10-3 mm2/sec (0.306 - 1.096 × 10-3 mm2/sec), and in the intermediate/hard consistency group was 0.509 × 10-3 mm2/sec (0.308 - 0.818 × 10-3 mm2/sec). There was no significant difference between the median values ​​of ADC, ADCR and signal on T1W between the soft and hard tumor groups, or between patients with and without tumor residue. CONCLUSION: Our results did not show usefulness of the DWI and T1WI for assessing the consistency of pituitary macroadenomas, nor as a predictor of the degree of surgical resection.

Endoscopic Endonasal Resection of Schwannoma of Pterygopalatine Fossa.

Trigeminal schwannomas are benign slow-growing tumors originating from the peripheral nerve sheath. They account for 0.1%-0.4% of all intracranial tumors and 1%-8% of all intracranial schwannomas.1-3 While most of these tumors develop in the trigeminal ganglion within the middle fossa, trigeminal schwannomas can develop anywhere along the course of the trigeminal nerve. As a result, they can be intradural, interdural, and extradural.4,5 Trigeminal schwannomas from the pterygopalatine fossa (PPF) are extremely rare and very difficult to remove because of limited access to this region and the rich neurovascular contents. Numerous traditional microsurgical approaches to the PPF have been described; however, they are more invasive with increased morbidity.6,7 Therefore, endoscopic endonasal surgery is a feasible solution. This technique allows good visualization of the region with decreased morbidity and a shorter recovery period. A previously healthy, 40-year-old woman presented with right facial pain for 3 weeks. On neurologic examination, the patient had hypoesthesia in the territory of the maxillary (V2) branch of the right trigeminal nerve. She had no other symptoms on physical examination. Cranial computed tomography and magnetic resonance imaging were performed and showed a high signal density mass in the right PPF that exhibited heterogeneous contrast enhancement. She was initially treated with low-dose carbamazepine; however, the dose could not be further increased because of drowsiness and dizziness. Given the size and location of the mass, an endoscopic endonasal approach was performed, and the tumor was successfully resected (Video 1). The postoperative course was uneventful, and the patient had significant improvement of her symptoms and was discharged with no new neurologic deficits. However, she continued to have hypoesthesia of the V2 segment of the trigeminal nerve.

Trigeminal Neuralgia due to Vertebrobasilar Dolichoectasia.

We presented a case of drug-resistant trigeminal neuralgia attributed to vertebrobasilar dolichoectasia, a rare condition characterized by enlargement, tortuosity, or elongation of intracranial arteries. Dolichoectatic vessels can cause dysfunction of cranial nerves through direct vascular compression. The relationships of vertebrobasilar dolichoectasia with the particularities of neurovascular conflict and images findings are discussed.