Adaptable Dual-Tuned Optically Controlled On-Coil RF Power Amplifier for MRI.

An adaptable optically controlled RF power amplifier (RFPA) is presented for direct implementation on the Magnetic Resonance Imaging (MRI) transmit coil. Operation at 1H and multiple X-nuclei frequencies for 7T MRI was demonstrated through the automated tuning of an effective voltage-modulated inductor located in the gate driver circuit of the FET switches in the different amplification stages. Through this automated tuning the amplifier can be adapted from the control to operate at the selected 1H and X-nuclei frequency in a multinuclear MRI study. Bench and MRI data acquired with the adaptable dual-tuned on-coil RFPA is presented. This technology should allow a simpler, more efficient and versatile implementation of the multinuclear multichannel MRI hardware. Ultimately, to extend the research on MRI detectable nuclei that can provide new insights about healthy and diseased tissue.

Advancements in Gradient System Performance for Clinical and Research MRI.

In magnetic resonance imaging (MRI), spatial field gradients are applied along each axis to encode the location of the nuclear spin in the frequency domain. During recent years, the development of new gradient technologies has been focused on the generation of stronger and faster gradient fields for imaging with higher spatial and temporal resolution. This benefits imaging methods, such as brain diffusion and functional MRI, and enables human imaging at ultra-high field MRI. In addition to improving gradient performance, new technologies have been presented to minimize peripheral nerve stimulation and gradient-related acoustic noise, both generated by the rapid switching of strong gradient fields. This review will provide a general background on the gradient system and update on the state-of-the-art gradient technology. EVIDENCE LEVEL: 5 TECHNICAL EFFICACY: Stage 1.

Eight-channel parallel transmit-receive system for 7 T MRI with optically controlled and monitored on-coil current-mode RF amplifiers.

PURPOSE: To demonstrate a practical implementation of an eight-channel parallel-transmit system for brain imaging at 7 T based on on-coil amplifier technology. METHODS: An eight-channel parallel transmit-receive system was built with optimized on-coil switch-mode current RF power amplifiers. The amplifiers were optically controlled from an eight-channel interface that was connected to a 7 T MRI scanner. The interface also optically received a down-converted version of the coil current sensed in each amplifier for monitoring and feedback adjustments. RESULTS: Each on-coil amplifier delivered more than 100 W peak power and provided enough amplifier decoupling (<-15 dB) for the implemented eight-channel array configuration. Phantom and human images were acquired to demonstrate practical operation of this new technology in a 7 T MRI scanner. CONCLUSION: Further development and improvement of previously demonstrated on-coil technology led to successful implementation of an eight-channel parallel-transmit system able to deliver strong B1 fields for typical brain imaging applications. This is an important step forward toward implementation of on-coil RF amplification for high-field MRI.

Optically controlled on-coil amplifier with RF monitoring feedback.

PURPOSE: To develop a new optically controlled on-coil amplifier that facilitates safe use of multi-channel radiofrequency (RF) transmission in MRI by real-time monitoring of signal phase and amplitude. METHODS: Monitoring was carried out with a 4-channel prototype system by sensing, down sampling, digitizing, and optically transmitting the RF transmit signal to a remote PC to control the amplifiers. Performance was evaluated with benchtop and 7 T MRI experiments. RESULTS: Monitored amplitude and phase were stable across repetitions and had standard deviations of 0.061 µT and 0.0073 rad, respectively. The feedback system allowed inter-channel phase and B1 amplitude to be adjusted within two iterations. MRI experiments demonstrated the feasibility of this approach to perform safe and accurate multi-channel RF transmission and monitoring at high field. CONCLUSION: We demonstrated a 4-channel transceiver system based on optically controlled on-coil amplifiers with RF signal monitoring and feedback control. The approach allows the safe and precise control of RF transmission fields, required to achieve uniform excitation at high field. Magn Reson Med 79:2833-2841, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Optically controlled switch-mode current-source amplifiers for on-coil implementation in high-field parallel transmission.

PURPOSE: We tested the feasibility of implementing parallel transmission (pTX) for high-field MRI using a radiofrequency (RF) amplifier design to be located on or in the immediate vicinity of an RF transmit coil. METHOD: We designed a current-source switch-mode amplifier based on miniaturized, nonmagnetic electronics. Optical RF carrier and envelope signals to control the amplifier were derived, through a custom-built interface, from the RF source accessible in the scanner control. Amplifier performance was tested by benchtop measurements as well as with imaging at 7T (300 MHz) and 11.7 T (500 MHz). The ability to perform pTX was evaluated by measuring interchannel coupling and phase adjustment in a two-channel setup. RESULTS: The amplifier delivered in excess of 44 W RF power and caused minimal interference with MRI. The interface derived accurate optical control signals with carrier frequencies ranging from 64 to 750 MHz. Decoupling better than 14 dB was obtained between two coil loops separated by only 1 cm. Application to MRI was demonstrated by acquiring artifact-free images at 7 T and 11.7 T. CONCLUSION: We propose an optically controlled miniaturized RF amplifier for on-coil implementation at high fields that should facilitate implementation of high-density pTX arrays. Magn Reson Med 76:340-349, 2016. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

A 7T spine array based on electric dipole transmitters.

PURPOSE: The goal of this study was to explore the feasibility of using an array of electric dipole antennas for RF transmission in spine MRI at high fields. METHOD: A two-channel transmit array based on an electric dipole design was quantitatively optimized for 7T spine imaging and integrated with a receive array combining eight loop coils. Using B1+ mapping, the transmit efficiency of the dipole array was compared with a design using quadrature loop pairs. The radiofrequency energy deposition for each array was measured using a home-built dielectric phantom and MR thermometry. The performance of the proposed array was qualitatively demonstrated in human studies. RESULTS: The results indicate dramatically improved transmit efficiency for the dipole design compared with the loop excitation. A gain of up to 76% was achieved within the spinal region. CONCLUSION: For imaging of the spine, electric dipole-based transmitters provide an attractive alternative to the traditional loop-based design. Easy integration with existing receive array technology facilitates practical use at high fields.

Characterization of a dielectric phantom for high-field magnetic resonance imaging applications.

PURPOSE: In this work, a generic recipe for an inexpensive and nontoxic phantom was developed within a range of biologically relevant dielectric properties from 150 MHz to 4.5 GHz. METHODS: The recipe includes deionized water as the solvent, NaCl to primarily control conductivity, sucrose to primarily control permittivity, agar-agar to gel the solution and reduce heat diffusivity, and benzoic acid to preserve the gel. Two hundred and seventeen samples were prepared to cover the feasible range of NaCl and sucrose concentrations. Their dielectric properties were measured using a commercial dielectric probe and were fitted to a 3D polynomial to generate a recipe describing the properties as a function of NaCl concentration, sucrose concentration, and frequency. RESULTS: Results indicated that the intuitive linear and independent relationships between NaCl and conductivity and between sucrose and permittivity are not valid. A generic polynomial recipe was developed to characterize the complex relationship between the solutes and the resulting dielectric values and has been made publicly available as a web application. In representative mixtures developed to mimic brain and muscle tissue, less than 2% difference was observed between the predicted and measured conductivity and permittivity values. CONCLUSIONS: It is expected that the recipe will be useful for generating dielectric phantoms for general magnetic resonance imaging (MRI) coil development at high magnetic field strength, including coil safety evaluation as well as pulse sequence evaluation (including B1(+) mapping, B1(+) shimming, and selective excitation pulse design), and other non-MRI applications which require biologically equivalent dielectric properties.

Identification and mitigation of interference sources present in SSB-based wireless MRI receiver arrays.

PURPOSE: Single sideband amplitude modulation (SSB) is an appealing platform for highly parallel wireless MRI detector arrays because the spacing between channels is ideally limited only by the MRI signal bandwidth. However this assumes that no other sources of interference are present outside that bandwidth. This work investigates the practical interference between multiple SSB-encoded MRI signals. METHODS: Noise from coil preamplifiers and carrier bleed-through are identified as sources of interference. Two different SSB systems were designed for 1.5 T with different noise filtering properties. We show how the differences between the filtered noise profiles impact the received MR signal's dynamic range (DRsig ) and image signal-to-noise ratio through simulation, bench measurements, and phantom imaging experiments. RESULTS: When operating individually in the MR scanner, both SSB systems were shown to minimally impact the original DRsig and signal-to-noise ratio. Conversely, when all eight channels were operating simultaneously, an average signal-to-noise ratio loss was observed to be 12% in the one system, while a second system with more complex filtering was able to achieve a 3% loss in signal-to-noise ratio. CONCLUSION: Successful wireless transmission of multiple SSB-encoded MRI signals is possible as long as channel interference is properly managed through design and simulation.

On-coil multiple channel transmit system based on class-D amplification and pre-amplification with current amplitude feedback.

A complete high-efficiency transmit amplifier unit designed to be implemented in on-coil transmit arrays is presented. High power capability, low power dissipation, scalability, and cost minimization were some of the requirements imposed to the design. The system is composed of a current mode class-D amplifier output stage and a voltage mode class-D preamplification stage. The amplitude information of the radio frequency pulse was added through a customized step-down DC-DC converter with current amplitude feedback that connects to the current mode class-D stage. Benchtop measurements and imaging experiments were carried out to analyze system performance. Direct control of B1 was possible and its load sensitivity was reduced to less than 10% variation from unloaded to full loaded condition. When using the amplifiers in an array configuration, isolation above 20 dB was achieved between neighboring coils by the amplifier decoupling method. High output current operation of the transmitter was proved on the benchtop through output power measurements and in a 1.5T scanner through flip angle quantification. Finally, single and multiple channel excitations with the new hardware were demonstrated by receiving signal with the body coil of the scanner.

Parallel excitation for B-field insensitive fat-saturation preparation.

Multichannel transmission has the potential to improve many aspects of MRI through a new paradigm in excitation. In this study, multichannel transmission is used to address the effects that variations in B(0) homogeneity have on fat-saturation preparation through the use of the frequency, phase, and amplitude degrees of freedom afforded by independent transmission channels. B(1) homogeneity is intrinsically included via use of coil sensitivities in calculations. A new method, parallel excitation for B-field insensitive fat-saturation preparation, can achieve fat saturation in 89% of voxels with M(z) ≤ 0.1 in the presence of ± 4 ppm B(0) variation, where traditional CHESS methods achieve only 40% in the same conditions. While there has been much progress to apply multichannel transmission at high field strengths, particular focus is given here to application of these methods at 1.5 T.