Photophysical Properties of Sinapic Acid and Ferulic Acid and Their Binding Mechanism with Caffeine.

Sinapic acid (SA) and ferulic acid (FA) are bioactive compounds used in the food, pharmaceutical, and cosmetic industries due to their antioxidant properties. In this work, we studied the photophysical properties of SA and FA in different solvents and concentrations and their interactions with caffeine (CF), using ultraviolet-visible (UV-Vis), fluorescence spectroscopy and Fourier transform infrared (FTIR) spectroscopy. The findings show that the quantum yield, fluorescence lifetime, radiative decay rates, and non-radiative decay rates of SA and FA are influenced by the concentrations and solvent polarity. The interaction between SA and FA with CF was also studied using UV-Vis and fluorescence spectroscopy. The results indicate that the CF quenched the fluorescence intensity of SA and FA by static quenching due to the formation of a non-fluorescent complex. The van't Hoff equation suggests that the van der Waals forces and hydrogen bonds force were responsible for the interaction between SA and CF, as indicated by a negative change in enthalpy ( Δ H o  < 0) and a negative change in entropy ( Δ S o  < 0). On the other hand, the interaction between FA and CF was primarily controlled by electrostatic force, as indicated by a negative change in enthalpy ( Δ H o < 0) and a positive change in entropy ( Δ S o > 0). The negative change in Gibbs free energy ( Δ G o ) indicates that both compounds underwent a spontaneous binding process.

Detection and photothermal inactivation of Gram-positive and Gram-negative bloodstream bacteria using photonic crystal biosensor and plasmonic core-shell.

Plasmonics and core-shell nanomaterials hold great potential to develop pharmaceuticals and medical equipment due to their eco-friendly and cost effective fabrication procedures. Despite these advancements, combating drug-resistant bacterial infections remains a global challenge. Therefore, this study aims to introduce a tailored theoretical framework for a one-dimensional (1D) photonic crystal biosensor (PCB) composed of (ZrO2/GaN)N/defect layer/(ZrO2/GaN)N, designed to detect Gram-positive and Gram-negative bloodstream bacteria employing the transfer matrix method (TMM). In addition, using the finite difference methods (FDM), the photothermal inactivation of bloodstream bacteria with plasmonic core-shell structures (FeO@AuBiS2) was explored using key factors such as light absorption, heat generation, and thermal diffusion. By incorporating six dielectric layers and contaminated blood into the proposed PCB, a maximum sensitivity of 562 nm per RIU was recorded, and using rod-shaped plasmonic core-shell structures, 5.8 nm-1 light absorption capacity and 152 K change in temperature were achieved. The maximum detection sensitivity, light absorption, heat conduction and heat convection capacity of the proposed 1D PCB and plasmonic core-shell show an effective approach to combating drug-resistant bacteria.