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In Vivo ; 34(3): 985-1000, 2020.
Article in English | MEDLINE | ID: mdl-32354884

ABSTRACT

BACKGROUND/AIM: A new manufacturing process has been established for the condensation of collagen derived from porcine pericardium to develop a new dental barrier membrane (CPM) that can provide a long barrier functionality. A native collagen membrane (PM) was used as control. MATERIALS AND METHODS: Established in vitro procedures using L929 and MC3T3 cells were used for cytocompatibility analyses. For the in vivo study, subcutaneous implantation of both membrane types in 40 BALB/c mice and established histological, immuno histochemical and histomorphometrical methods were conducted. RESULTS: Both the in vitro and in vivo results revealed that the CPM has a biocompatibility profile comparable to that of the control membrane. The new CPM induced a tissue reaction including more M2-macrophages. CONCLUSION: The CPM is fully biocompatible and seems to support the early healing process. Moreover, the new biomaterial seems to prevent cell ingrowth for a longer period of time, making it ideally suited for GBR procedures.


Subject(s)
Bone Regeneration , Collagen/metabolism , Guided Tissue Regeneration , Membranes, Artificial , Animals , Biocompatible Materials , Biomarkers , Female , Fibroblasts , Immunohistochemistry , Macrophages/metabolism , Mice , Pericardium , Proteolysis , Swine , Time Factors
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