Subject(s)
Antiviral Agents/toxicity , Cell Cycle Proteins/genetics , Mitochondrial Myopathies/chemically induced , Mitochondrial Myopathies/genetics , Ribonucleotide Reductases/genetics , Thymidine/analogs & derivatives , Aged , Antiviral Agents/administration & dosage , Female , Hepatitis B, Chronic/drug therapy , Hepatitis B, Chronic/surgery , Humans , Liver Transplantation , Mutation , Telbivudine , Thymidine/administration & dosage , Thymidine/toxicityABSTRACT
We report the case of a 59-year-old woman who presented with several episodes of transient ischemic attack (TIA) caused by pathologically confirmed giant cell arteritis. She continued suffering from TIAs during admission despite immunosuppressant and antithrombotic therapy. Sudden neurological deterioration with paraparesis and cognitive impairment developed. A brain magnetic resonance (MR) imaging showed bilateral watershed ischemic lesions. MR angiography demonstrated severe stenosis of both intracranial internal carotid arteries (ICAs). Angioplasty and stenting on the left ICA were performed, with evident clinical improvement occurring within 24 hours. Endovascular therapy may be an alternative option to treat severe GCA with symptomatic intracranial large vessel disease not responsive to intensive conventional medical treatment.
