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1.
J Clin Med ; 11(9)2022 Apr 23.
Article in English | MEDLINE | ID: mdl-35566489

ABSTRACT

Background: Chemotherapy-related cognitive impairment (CRCI), or "chemobrain," isdefined as a phenomenon of cognitive deficits in cancer patients after chemotherapy and is characterized by deficits in areas of cognition, including memory, attention, speed of processing, and executive function, which seriously affect quality of life. The purpose of this study is to investigate the impact of CRCI in breast cancer (BC) patients in chemotherapy treatment (CT+) or not (CT−) and to analyze their relationship with detectable objective changes in cerebral activity during the execution of a phonological and semantic verbal fluency task (PVF and SVF). Methods: An observational, cross-sectional study was carried out at Badajoz University Hospital (Spain). A total of 180 women with BC were included. We used Cognitive Scale (FACT-Cog) for neuropsychological subjective assessment, obtaining scores of perceived cognitive impairment (PCI), and near-infrared spectroscopy system (NIRS) for neuropsychological objective assessment during a verbal fluency task (PVF and SVF), determining alterations in the prefrontal cortex (PFC) assessed as changes in regional saturation index (rSO2). Results: A total of 41.7% percent of the patients in the sample had PCI. CT+ was significantly associated with a worse impact in PCI (X¯ = 50.60 ± 15.64 vs. X¯ = 55.01 ± 12.10; p = 0.005). Average rSO2 decreased significantly in CT+ (X¯ = 63.30 ± 8.02 vs. X¯ = 67.98 ± 7.80; p < 0.001), and BC patients showed a significant decrease in PVF and SVF on average (X¯ = 41.99 ± 9.52 vs. X¯ = 47.03 ± 9.31, and X¯ = 33.43 ± 11.0 vs. X¯ = 36.14 ± 10.68, respectively; p < 0.001). Conclusions: Our findings suggest that cognitive impairments in the domain of executive functioning exist among patients with BC who received CT. The results corroborate the hypothesis that CT is an important factor in cognitive impairment in patients with BC, which has been demonstrated by both subjective (PCI) and objective (PVF, SVF, and rSO2) neuropsychological measures. The combination of doxorubicin, cyclophosphamide, and docetaxel induce cognitive impairment.

2.
Article in English | MEDLINE | ID: mdl-35329232

ABSTRACT

Breast cancer (BC) is a major public health problem internationally. Although illness survival rates have improved, patients usually suffer multiple symptoms, both physical and psychological, which can affect their quality of life (QoL). The main aim of this study was to evaluate depressive symptoms, anxiety and the QoL of people with BC. An observational, cross-sectional study was carried out at Badajoz University Hospital (Spain). A total of 200 women with BC were included. EORTC QLQ-C30 and QLQ-BR23 questionnaires were used to assess QoL. Patients were screened for depressive symptoms using the Beck Depression Inventory (BDI) and for state anxiety and trait anxiety using the State Anxiety Inventory (STAI). Thirty-eight percent of the patients in the sample had moderate to severe anxiety, which was related to the time of diagnosis, advanced stage of illness and surgical treatment. We found that 28% of patients had depressive symptoms, related mainly with time of diagnosis, adjuvant therapy and number of cycles of chemotherapy (CT). Patients with the longest time since diagnosis, in stage III, and in treatment with CT, especially those with the greatest number of cycles, had the worst scores in QoL. We found a positive association between depressive symptoms and anxiety with QoL in patients with BC.


Subject(s)
Breast Neoplasms , Quality of Life , Anxiety/epidemiology , Breast Neoplasms/psychology , Cross-Sectional Studies , Depression/epidemiology , Depression/psychology , Female , Humans , Male , Surveys and Questionnaires
3.
Article in English | MEDLINE | ID: mdl-34831683

ABSTRACT

BACKGROUND: Shift working is associated with a profound desynchronization of circadian rhythm and in particular, night-shift work disrupts normal circadian physiology. Sleep deprivation affects the functioning of certain brain areas and thus impairs cognitive performance. The purpose of this study was to investigate the effects of the night shift on cognitive performance and cerebral oxygenation/haemodynamics. METHODS: A prospective, observational, comparative, randomized and cross-over study was carried out. A total of 74 intensive care unit nurses in Spain were included in the study. The following variables were measured: sociodemographic, burnout, anxiety, baseline cerebral oxygenation levels on night and day shift using a near-infrared spectroscopy system and cognitive task performance during a verbal fluency task to evaluate the alterations in the prefrontal cortex, assessed as changes in regional saturation index. RESULTS: The average regional saturation index decreased significantly in the night shift (r = 0.560, p < 0.001). The ICU nurses showed a significant decrease in the verbal fluency test on average (8.53 ± 8.49, p < 0.001) and, in general, there was also a significant increase in anxiety score (3.17 ± 7.56, p = 0.001). CONCLUSIONS: Sleep deprivation during the night shift was considered to be related to decreased dorsolateral PFC reactivity. After the night shift, the nurses showed a decrease in prefrontal cortex activity and in cognitive performance.


Subject(s)
Nurses , Spectroscopy, Near-Infrared , Brain , Circadian Rhythm , Cross-Over Studies , Humans , Intensive Care Units , Prospective Studies , Sleep , Work Schedule Tolerance
4.
Enferm. clín. (Ed. impr.) ; 31(5): 313-322, Sep-Oct. 2021. tab, graf
Article in Spanish | IBECS | ID: ibc-220654

ABSTRACT

Objetivo: Analizar la relación entre la calidad de vida relacionada con la salud (CVRS) y variables sociodemográficas y clínicas de pacientes diagnosticados de diabetes mellitus, comparando además con los valores de referencia para la población española. Método: Estudio descriptivo-analítico observacional trasversal por muestreo no probabilístico intencional en pacientes con diabetes mellitus del Centro de Salud San Roque (Badajoz, España), usando cuestionarios de datos sociodemográficos y de cuidado de la diabetes, los cuestionarios SF-36 y Duke-UNC, y datos de la historia clínica. Resultados: Se estudiaron 60 pacientes (55% mujeres) fundamentalmente con diabetes tipo 2 (90%) y una edad media de 68,67±11,09 años. Las mujeres mayores de 75 años presentaron valores de CVRS significativamente inferiores a los de su grupo poblacional de referencia. Las mujeres mostraron una peor CVRS que los hombres. La edad, los años de evolución de la diabetes, la presencia de complicaciones agudas y crónicas, así como de comorbilidades, el régimen farmacológico y el control glucémico afectan a la CVRS. Vivir solo, tener un nivel socioeconómico bajo, un apoyo social percibido bajo y necesitar ayuda para el cuidado de la diabetes están relacionados con una deficiente CVRS. Conclusiones: La evaluación de la CVRS permite detectar alteraciones en sus diferentes dominios e intervenir precozmente, pudiendo incorporar estos aspectos a la valoración e intervención enfermera en el plan de cuidados, lo que permite establecer estrategias individualizadas de atención y programas de educación diabetológica que contribuyan a la mejora de la calidad de vida en pacientes con diabetes.(AU)


Objective: To analyse the relationship between health-related quality of life (HRQoL) and sociodemographic and clinical factors in patients with diabetes mellitus, also comparing with Spanish population-based reference values. Method: Cross-sectional descriptive-analytical observational study through nonprobability sampling on diabetic patients from San Roque Primary Health Centre (Badajoz, Spain), using a questionnaire regarding sociodemographic and diabetes care data, SF-36 and Duke-UNC questionnaires, and clinical history data. Results: Sixty patients (55% women) fundamentally with type 2 diabetes and a mean age of 68.67±11.09 years were studied. Women older than 75 presented poorer HRQoL than their reference group. Women showed worse HRQoL than men. Age, evolution of diabetes, presence of acute and chronic complications, and comorbidities, pharmacological treatment, and glycaemic control affect HRQoL in these patients. Living alone, having a low socioeconomic status, and needing help with diabetes-related self-care can negatively affect quality of life. Conclusions: HRQoL assessment allows us to detect alterations in the different domains and perform an early intervention. This way, we can incorporate these aspects into the nursing evaluation and interventions in the nursing care plan; allowing us to develop individualized care strategies and diabetes education programmes that contribute to improving HRQoL in patients with diabetes.(AU)


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Diabetes Mellitus , Quality of Life , Polypharmacy , Comorbidity , Diabetes Complications , Cross-Sectional Studies , Spain , Epidemiology, Descriptive
5.
Oncol Nurs Forum ; 48(5): 535-545, 2021 09 01.
Article in English | MEDLINE | ID: mdl-34411080

ABSTRACT

OBJECTIVES: To assess the relationship between (a) chemotherapy and monoclonal antibody (mAb) treatments and (b) depressive symptoms and quality of life (QOL) in patients with breast cancer. SAMPLE & SETTING: 182 women with breast cancer in Spain who were undergoing chemotherapy with or without mAbs. METHODS & VARIABLES: An observational, cross-sectional study was carried out. The European Organisation for Research and Treatment of Cancer (EORTC) QOL Questionnaire-Core 30 and the EORTC QOL Questionnaire-Breast Cancer were used to assess QOL. Patients were screened for depressive symptoms using the Beck Depression Inventory-II. RESULTS: No relationship was found between the use of mAbs with chemotherapy and QOL, except for incidence of diarrhea. However, depressive symptoms had a negative and highly significant influence on the majority of the QOL parameters. IMPLICATIONS FOR NURSING: The presence of depressive symptoms negatively affects QOL. Used concurrently, mAbs and chemotherapy do not negatively influence QOL, but some adverse effects, such as diarrhea, are common.


Subject(s)
Breast Neoplasms , Quality of Life , Antibodies, Monoclonal/adverse effects , Breast Neoplasms/drug therapy , Cross-Sectional Studies , Depression/chemically induced , Female , Humans , Surveys and Questionnaires
6.
Enferm Clin (Engl Ed) ; 31(5): 313-322, 2021.
Article in English | MEDLINE | ID: mdl-34376354

ABSTRACT

OBJECTIVE: To analyse the relationship between health-related quality of life (HRQoL) and sociodemographic and clinical factors in patients with diabetes mellitus, also comparing with Spanish population-based reference values. METHOD: Cross-sectional descriptive-analytical observational study through nonprobability sampling on diabetic patients from San Roque Primary Health Centre (Badajoz, Spain), using a questionnaire regarding sociodemographic and diabetes care data, SF-36 and Duke-UNC questionnaires, and clinical history data. RESULTS: Sixty patients (55% women) fundamentally with type 2 diabetes and a mean age of 68.67 ± 11.09 years were studied. Women older than 75 presented poorer HRQoL than their reference group. Women showed worse HRQoL than men. Age, evolution of diabetes, presence of acute and chronic complications, and comorbidities, pharmacological treatment, and glycaemic control affect HRQoL in these patients. Living alone, having a low socioeconomic status, and needing help with diabetes-related self-care can negatively affect quality of life. CONCLUSIONS: HRQoL assessment allows us to detect alterations in the different domains and perform an early intervention. This way, we can incorporate these aspects into the nursing evaluation and interventions in the nursing care plan; allowing us to develop individualized care strategies and diabetes education programmes that contribute to improving HRQoL in patients with diabetes.


Subject(s)
Diabetes Mellitus, Type 2 , Quality of Life , Aged , Cross-Sectional Studies , Diabetes Mellitus, Type 2/therapy , Female , Humans , Male , Middle Aged , Primary Health Care , Surveys and Questionnaires
7.
Psychol Res Behav Manag ; 13: 1011-1025, 2020.
Article in English | MEDLINE | ID: mdl-33262666

ABSTRACT

INTRODUCTION: Alzheimer's disease (AD) caregivers resilience involves the interaction between different risk and protective factors. Context of care, objective stressors, perceived stressors caregiver assessment, mediators factors and consequences of care were associated with resilience. We have developed a more integrated and operational conceptual model of resilience and care than previous models in our sociocultural environment. PURPOSE: To assess the resilience of caregivers of people with AD and the related factors grouped according to an established operational conceptual model of Alzheimer´s caregivers stress. PATIENTS AND METHODS: A total of 120 primary informal caregivers of AD persons in Badajoz (Spain) were included in a cross-sectional design. The following variables have been measured on AD persons and caregivers: socio-demographic data, dependency level, cognitive decline, neuropsychiatric and behavioral symptoms, anxiety, depression, severity of somatic symptoms, level of burden, self-esteem, coping, social support, health-related quality of life (HRQOL) and resilience. RESULTS: Most of the caregivers reported symptoms of anxiety (63.3%) and depression (62.5%). We found out higher levels of resilience in caregivers with lower dependence caring (p=0.004). Higher resilience levels of caregivers were related to minor depressive (p=0.006) and anxiety symptoms (p=0.000), and higher HRQOL (p=0.000). Coping dimension mostly used was problem-based strategies such as active coping, positive reinterpretation and acceptance (p= 0.000). CONCLUSION: Those caregivers reporting higher levels of resilience exhibited moderate to intense indicators of burden, fewer symptoms of depression and anxiety and fewer somatic symptoms. They also used adequate problem-focused coping strategies, showed higher levels of HRQOL and demonstrated an appropriate perception of social support. Despite the fact that the characteristics relating to the care context and to social support exert an undeniable influence on caregiver resilience, it would appear that the caregiver's own intra-psychic resources reveal stronger correlations. RELEVANCE FOR CLINICAL PRACTICE: The early and accurate identification of caregivers with lower levels of resilience could enable the implementation of vital psychological and educative support interventions to help caregivers to improve their well-being.

8.
Ther Clin Risk Manag ; 15: 965-977, 2019.
Article in English | MEDLINE | ID: mdl-31447561

ABSTRACT

Monoclonal antibodies constitute important and useful tools in clinical practice and biotechnology for diagnosing and treating infectious, inflammatory, immunological and neoplastic diseases. This article reviews evidence on the different acute adverse effects of monoclonal antibodies, specifically infusion-related reactions (IRRs), and on the measures that should be taken before and during crises. A literature search using key terms relating to IRRs produced by monoclonal antibodies was undertaken to generate a comprehensive narrative review of the information available. Immunomodulatory monoclonal antibodies may produce IRRs and hypersensitivity-related reactions. Strategies to avoid or minimize the appearance of IRRs depend on the monoclonal antibody and type of patient and reaction (pre-medication, slowing infusion rates, infusion interruption or desensitization, etc.). Considering the great number of available monoclonal antibodies in current practice and those which will soon be authorized, it is mandatory to have clear guidelines that can give support to practitioners and nurses to help them respond quickly and safely to the different IRRs related to the use of these therapeutic drugs.

9.
Cancer Manag Res ; 9: 545-551, 2017.
Article in English | MEDLINE | ID: mdl-29138595

ABSTRACT

PURPOSE: The aim of this study was to analyze and compare foot health and general health in a sample of women divided into two groups: 1) those with breast cancer and undergoing chemotherapy treatment and 2) healthy women without breast cancer and with normalized reference values. METHODS: A case-control observational study was performed. Two-hundred women with a mean age of 51.00±8.75 years were recruited from podiatric medicine and surgery clinics from the University of Extremadura (Plasencia, Spain) and the Hospital Infanta Cristina (Badajoz, Spain). The women were divided into case and control groups (undergoing chemotherapy treatment and healthy women, respectively). The Foot Health Status Questionnaire was used to assess foot health domain scores. RESULTS: Significant differences between both groups were seen for foot pain (P=0.003), foot function (P<0.001), physical activity (P<0.001), social capacity (P<0.001), and vigor (P=0.001). The remaining domains (footwear, general health, and foot health) did not show significant differences between the two groups (P≥0.01). CONCLUSION: Women with breast cancer presented a lower foot health-related quality of life. Clinical aspects with emphasis on foot pain and disability were increased. Furthermore, physical activity, social capacity, and vigor were affected. Therefore, general health care and foot problem prevention for breast cancer survivors should be given more consideration.

10.
Rev. Rol enferm ; 40(7/8): 524-530, jul.-ago. 2017. tab
Article in Spanish | IBECS | ID: ibc-164891

ABSTRACT

Los anticuerpos monoclonales (mAb) son una poderosa herramienta para el diagnóstico y tratamiento de muchas enfermedades. En los últimos años la Agencia Española de Medicamentos y Productos Sanitarios (AEMPS) ha autorizado la comercialización de nuevos mAb y otros se incorporarán en un futuro próximo. Los profesionales de enfermería, como responsables de la administración, deben conocer las características más importantes de este tipo de herramientas terapéuticas. Se pretende relacionar los diferentes tipos de mAb aprobados en España, sus indicaciones terapéuticas y reacciones adversas, así como destacar otros aspectos importantes sobre el desarrollo de estos nuevos fármacos en el mercado. Los mAb son eficaces para el tratamiento de enfermedades oncológicas, reumatológicas, dermatológicas o neurológicas, entre otras. Además, se están desarrollando numerosos ensayos clínicos con otros nuevos mAb que incrementarán el número de fármacos disponibles, así como nuevas indicaciones para los ya existentes. Aunque la introducción de estos nuevos productos en el mercado está contribuyendo a disminuir la mortalidad y mejorar la calidad de vida de los pacientes, en la práctica clínica existe un gran debate sobre la necesidad de aprobar tantos nuevos fármacos con altos costes para el sistema sanitario y con un beneficio dudoso con respecto al resto de los de su grupo ya comercializados (AU)


Monoclonal antibodies (mAb) are a powerful tool for numerous illnesses' diagnosis and therapy. Over the last few years, the Spanish Agency for Medical Drugs and Health Products (AEMPS) has approved the merchandising of new mAb. Many more approvals are expected to come in the near future. Nursing professionals, responsible for drug administration, should know the most important characteristics of this type of therapeutic tools. Our aim is to link the different types of mAb licensed in Spain, their therapeutic indications, adverse effects, and point out important aspects of the development of these new drugs in the pharmacological market. MAb are very effective for the treatment of oncologic, dermatologic and neurologic diseases among others. Ongoing medical trials with new mAb will increase the current available arsenal, including new indications on the already approved drugs. Although the introduction of this new class of drugs in the pharmaceutical market is reducing mortality and improving the quality of patients' lives, an important debate is going on in real clinical practice over the need to endorse so many new drugs, which pose a huge economic burden on the National Health System and doubtful advantages in comparison to the rest of readily commercialized mAb (AU)


Subject(s)
Humans , Antibodies, Monoclonal/administration & dosage , Antibodies, Monoclonal/classification , Antibodies, Monoclonal/therapeutic use , Quality of Life , Antineoplastic Agents/administration & dosage , Immunosuppressive Agents/administration & dosage , Drug Monitoring/nursing , Drug-Related Side Effects and Adverse Reactions/nursing , Pharmacovigilance
12.
Nurs Outlook ; 65(5): 562-571, 2017.
Article in English | MEDLINE | ID: mdl-28209411

ABSTRACT

BACKGROUND: The use of bibliometric indicators (impact factor [IF], impact index, h-index, etc.) is now believed to be a fundamental measure of the quality of scientific research output. In this context, the presence of scientific nursing journals in international databases and the factors influencing their impact ratings is being widely analyzed. PURPOSE: The aim of this study was to analyze the presence of scientific nursing journals in international databases and track the changes in their IF. METHODS: A secondary analysis was carried out on data for the years 2009 to 2014 held in the JCR database (subject category: nursing). Additionally, the presence of scientific nursing journals in Medline, CINAHL, Scopus, and SJR was analyzed. DISCUSSION: During the period studied, the number of journals indexed in the JCR under the nursing subject category increased from 70 in 2009 (mean IF: 0.99, standard deviation: 0.53) to 115 in 2014 (mean IF: 1.04, standard deviation: 0.42), of which only 70 were listed for the full six years. Although mean IF showed an upward trend throughout this time, no statistically significant differences were found in the variations to this figure. CONCLUSION: Although IF and other bibliometric indicators have their limitations, it is nonetheless true that bibliometry is now the most widely used tool for evaluating scientific output in all disciplines, including nursing, highlighting the importance of being familiar with how they are calculated and their significance when deciding the journal or journals in which to publish the results of our research. That said, it is also necessary to consider other possible alternative ways of assessing the quality and impact of scientific contributions.


Subject(s)
Bibliometrics , Journal Impact Factor , Nursing Research , Publications/statistics & numerical data , Humans
17.
Rev Enferm ; 36(7-8): 28-34, 2013.
Article in Spanish | MEDLINE | ID: mdl-23951670

ABSTRACT

Pain leads to unpleasant sensory or emotional experience for any individual. In the elderly, given their biopsychosocial characteristics, the pain requires a specific approach, different from other age groups: this is the objective of this article, which dealt with the different types of pain, the assessment and treatment of the same.


Subject(s)
Pain , Age Factors , Aged , Humans , Pain/diagnosis , Pain/drug therapy , Pain/etiology , Pain Management
18.
Rev. Rol enferm ; 36(7/8): 500-506, jul.-ago. 2013. tab, ilus
Article in Spanish | IBECS | ID: ibc-115212

ABSTRACT

El dolor conlleva una experiencia sensorial o emocional desagradable para cualquier individuo. En el anciano, dadas sus peculiaridades biopsicosociales, el dolor requiere un abordaje específico, diferente al resto de grupos de edad: este es el objetivo del presente artículo, en el que se abordan los diferentes tipos de dolor, la valoración y el tratamiento del mismo(AU)


Pain leads to unpleasant sensory or emotional experience for any individual. In the elderly, given their biopsychosocial characteristics, the pain requires a specific approach, different from other age groups: this is the objective of this article, which dealt with the different types of pain, the assessment and treatment of the same(AU)


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Pain/nursing , Pain Clinics , Pain Management/nursing , Chronic Disease/nursing , Health Services for the Aged , Aged/psychology , Health of the Elderly , /psychology
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