ABSTRACT
The present study compares two protocols for ovarian controlled stimulation in terms of number of cumulus-oocyte complexes and metaphase II oocytes. We employed a single injection of 150mcg of corifollitropin alfa after a 7-day oral contraceptive pill-free interval for TAIL group and a conventional administration of corifollitropin alfa after a 5-day OCP-free interval with additional rFSH from 8th of ovarian controlled stimulation. Prospective, randomized, comparative, non-inferiority, opened and controlled trial carried out in 180 oocyte donors 31 were excluded, 81 were randomized to the control group and 68 to the TAIL group. No differences were found in the number of follicles larger than 14 and 17â mm at triggering day. However, a lower number of cumulus-oocyte complexes and metaphase II oocytes were obtained in TAIL group compared to the control group, expressed as median (interquartile range): 10.5 (5.5-19) vs. 14 [11-21] and 9 (4-13) vs. 12 (9-17) respectively. Additionally, the incidence of failed retrieval or metaphase II oocytes = 0 was higher in TAIL group 7(10.3%) vs. 1(1.2%) p = 0.024. The use of a single injection of corifollitropin alfa after a 7-day oral contraceptive pill-free interval in oocyte donors resulted in a lower number of cumulus-oocyte complexes and metaphase II oocytes. No additional rFSH was administered in this group. Clinical Trial Registration: https://www.clinicaltrialsregister.eu/ctr-search/trial/2019-001343-44/results.
ABSTRACT
OBJETIVO: Conocer la posible relación entre la calidad de los embriones transferidos en ciclos de Fecundación In Vitro (FIV) y Microinyección Intracitoplásmica de Espermatozoides (ICSI) con la presencia de anomalías fetales. MATERIAL Y MÉTODOS: Análisis retrospectivo incluyendo casos de anomalías congénitas (n=76), comparándolos con un grupo control (n=240) de nacimientos tras técnicas de reproducción asistida (TRA). Según los tipos de embriones obtenidos, se dividieron los casos en transferencia de calidad alta, media y baja. RESULTADOS: La aparición de defectos es similar con embriones de calidad alta (22,5 %) y media (21,8 %) pero se incrementa cuando se emplean los de baja calidad (40,0 %). Es similar en cuanto a la técnica empleada (FIV o ICSI), gestación única o múltiple, cultivo corto o largo. Sí hay influencia según la edad materna. CONCLUSIÓN: La transferencia de embriones de baja calidad, se asocia a la aparición de un mayor número de defectos congénitos
OBJECTIVE: To find out the possible correlation between the quality of embryos transferred in In Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) cycles and fetal anomalies. MATERIALS AND METHODS: Retrospective study including cases of congenital anomalies (n=76), compared to the control group (n=240) in births after assisted reproductive techniques (ART). Depending on the type of embryos obtained, the cases were divided into cases of high, medium and low quality transfer. RESULTS: The appearance of defects is similar between high (22.5 %) and medium (21.8 %) quality embryos, but increase when low quality embryos are used (40.0 %). This is similar in both techniques (IVF or ICSI), single or multiple pregnancies, long and short cultures. Maternal age does have an influence. CONCLUSION: Transferring low quality embryos is related to the appearance of a higher number of congenital defects
