Synthesis, antimicrobial and cytostatic activity of 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranosyl (-)-(S)-propanesulfinate.

The synthesis of 1,2:5,6-di-O-isopropilidene-alpha-D-glucofuranosyl (-)-(S)-propanesulfinate 1 optically pure using diacetone-D-glucose as unique inducer of chirality and iPrEtN a base is described. Compound 1 was especially active against Gram positive bacteria. For the cytostatic activity, the ID50 value of compound 1 was inferior than those recommend by National Cancer Institute of USA for this type of compounds.