ABSTRACT
BACKGROUND: Breast cancer is the most common cancer in women worldwide. Approximately 70% of female breast cancer patients have a body mass index (BMI) >25. In obesity, adipose tissue secretes additional resistin, which prompts a proinflammatory effect through its action on adenylate cyclase-associated protein 1 (CAP1). Several studies have associated the RETN gene single nucleotide polymorphism (SNP) rs1862513 (-420CSubject(s)
Biomarkers, Tumor/genetics
, Breast Neoplasms/blood
, Breast Neoplasms/genetics
, Cell Cycle Proteins/genetics
, Cytoskeletal Proteins/genetics
, Polymorphism, Single Nucleotide
, Resistin/genetics
, Adult
, Alleles
, Body Mass Index
, Breast Neoplasms/ethnology
, Breast Neoplasms/pathology
, Case-Control Studies
, Female
, Gene Expression
, Genetic Carrier Screening
, Humans
, Mexico
, Middle Aged
, Obesity/ethnology
, Obesity/genetics
, Postmenopause
, Premenopause
, Resistin/blood
