1.
J Pediatr
; 155(5): 752-5.e1-3, 2009 Nov.
Article
in English
| MEDLINE
| ID: mdl-19840619
ABSTRACT
A 17-year-old boy with chromosomal mosaicism resulting in a 45,X/46,X,idic(Y)(p11) karyotype came to medical attention at the age of 10 years because of short stature. He was treated with recombinant growth hormone for 6.6 years and has achieved a near final adult height of 172.5 cm. His clinical features included second-degree hypospadias, some stigmata of Turner syndrome, and spontaneous progression through puberty. We report long-term use of growth hormone in a male adolescent with isodicentric Yq.
Subject(s)
Body Height/drug effects , Growth Disorders/drug therapy , Human Growth Hormone/therapeutic use , Noonan Syndrome/drug therapy , Adolescent , Chromosome Aberrations , Chromosomes, Human, X , Chromosomes, Human, Y , Dose-Response Relationship, Drug , Drug Administration Schedule , Follow-Up Studies , Growth Disorders/diagnosis , Growth Disorders/genetics , Humans , Hypospadias/diagnosis , Hypospadias/surgery , Karyotyping , Male , Noonan Syndrome/diagnosis , Time Factors , Treatment Outcome
2.
Mt Sinai J Med
; 75(6): 556-7, 2008 Dec 01.
Article
in English
| MEDLINE
| ID: mdl-19021194
