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Nat Prod Res ; 33(19): 2830-2836, 2019 Oct.
Article in English | MEDLINE | ID: mdl-30394108

ABSTRACT

A new A, D-seco limonoid, named 12-acetyloxyperforatin (1), along with three known ones, were isolated from the leaves of Harrisonia perforata. Their structures were elucidated on the basis of spectroscopic analysis, including extensive NMR techniques and computational modelling. These compounds showed no inhibitory activity against the 11ß-HSD1 enzyme.


Subject(s)
Enzyme Inhibitors/pharmacology , Limonins/chemistry , Simaroubaceae/chemistry , 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors , 11-beta-Hydroxysteroid Dehydrogenase Type 1/genetics , 11-beta-Hydroxysteroid Dehydrogenase Type 1/metabolism , 11-beta-Hydroxysteroid Dehydrogenase Type 2/antagonists & inhibitors , 11-beta-Hydroxysteroid Dehydrogenase Type 2/metabolism , Animals , Drug Evaluation, Preclinical , Enzyme Inhibitors/chemistry , Humans , Limonins/pharmacology , Magnetic Resonance Spectroscopy , Mice , Models, Molecular , Molecular Structure , Plant Leaves/chemistry
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