ABSTRACT
Objective: To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis (SOP), and to explore the related mechanisms. Methods: A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group, with 35 cases in each group. The control group was treated with conventional drugs, and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs. Both groups were treated for 3 months. Before and after treatment, assessed the visual analog scale (VAS) and Oswestry disability index (ODI) scores, determined the bone mineral density of the participants' lumbar spine (L2-L4) and left femoral neck, and detected the participants' serum bone morphogenetic protein-2 (BMP-2) and osteoprotegerin (OPG) levels. Results: After treatment, the VAS scores of both groups were lower than before treatment (both P<0.05), and the VAS score of the observation group was significantly lower than that of the control group (P<0.05). After treatment, the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment (both P<0.05), and the bone mineral density values of the observation group were higher than those of the control group (P<0.05). After treatment, the ODI scores of the two groups were lower than those before treatment (both P<0.05), and the ODI score of the observation group was lower than that of the control group (P<0.05). After treatment, the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group (both P<0.05). Conclusion: Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients' pain, improve dysfunction, and increase bone density, which may be related to the improvement of the serum BMP-2 and OPG levels.
ABSTRACT
For understanding the quantitative effect of nonhydrostatic stress on properties of material, the crystal structure and Raman spectra of 3C-SiC under hydrostatic and nonhydrostatic stress were calculated using a first-principles method. The results show that the lattice constants (a, b, and c) under nonhydrostatic stresses deviate those under hydrostatic stress. The differences of the lattice constants under hydrostatic stress from nonhydrostatic stresses with differential stress were fitted by linear equation. Nonhydrostatic stress has no effect on density of 3C-SiC at high pressure, namely the equations of state of 3C-SiC under hydrostatic stress are same as those under nonhydrostatic stress. The frequencies and pressure dependences of LO and TO modes of 3C-SiC Raman spectra under nonhydrostatic stress are just same as those under hydrostatic stress. Under nonhydrostatic stress, there are four new lines with 361, 620, 740, and 803 cm-1 appeared in the Raman spectra except for the LO and TO lines because of the reduction of structure symmetry. However the frequencies and pressure dependences of the four Raman modes remain unchanged under different nonhydrostatic stresses. Appearance of new Raman modes under nonhydrostatic stress and the linear relationship of the differences of lattice constants under hydrostatic and nonhydrostatic stresses with differential stress can be used to indicate state of stress in high pressure experiments. The effect of nonhydrostatic stress on materials under high pressure is complicated and our calculation would help to understanding state of stress at high pressure experiments.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the histogenesis, clinicopathologic characteristics, pathologic diagnosis, differential diagnosis, treatment and prognosis of basal cell carcinoma of the Prostate (BCCP).</p><p><b>METHODS</b>We conducted clinicopathologic analysis on the manifestations of 5 cases of BCCP by HE staining and immunohistochemistry and reviewed relevant literature.</p><p><b>RESULTS</b>Microscopically, the tumor cells were small in volume with ovoid karyomegaly and mitosis, some arranged like a solid nest or with a cribriform appearance. The tumors displayed an invasive growth, with positive expressions of 34betaE12, P63 and Cytokeratin 14, and negative expressions of PSA and P504s. No recurrence and metastasis were found in these patients during over 12 months of follow-up after surgery.</p><p><b>CONCLUSION</b>BCCP is a rare neoplasm different from prostate adenocarcinoma. Immunohistochemistry is indispensable in distinguishing this tumor from other types of prostatic carcinoma. Its biological behavior remains to be further studied. The best treatment option may be radical surgery combined with chemo-radiotherapy at the present time.</p>
