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1.
Arch Mal Coeur Vaiss ; 97(9): 921-4, 2004 Sep.
Article in French | MEDLINE | ID: mdl-15521487

ABSTRACT

The authors report the case of a 5 years old infant with cardiogenic shock due to a fulminant myocarditis. The severity of the shock which was refractory to conventional therapies necessitated to require to a cardiopulmonary bypass on emergency, followed by an external pneumatic bi-ventricular assistance. After 10 days (3 days with cardioplumonary bypass and 7 days of bi-ventricular assistance), the patient had been able to be disconnected of any mechanical circulatory supply with total recovery of the cardiac function.


Subject(s)
Cardiopulmonary Bypass , Heart-Assist Devices , Myocarditis/surgery , Shock, Cardiogenic/surgery , Child, Preschool , Humans , Male , Myocarditis/complications , Recovery of Function/physiology , Shock, Cardiogenic/etiology
2.
C R Acad Sci III ; 321(5): 437-42, 1998 May.
Article in French | MEDLINE | ID: mdl-9766192

ABSTRACT

The recent development of less invasive intracardiac surgery using small incisions and videoscopic techniques allowed an evaluation of the advantages and limitations of this new approach. Among the limitations was the increased difficulty of the surgical technique when using long instruments through small incisions and ports. We investigated whether computer assisted surgical instruments might bring a solution to this problem. Among the existing systems, we selected the Intuitive System because of two original features. It provides a stable, magnified, three dimensional view of the operating field at a console where the surgeon is seated to operate, and it uses computer assisted instruments having the same dexterity and range of motion as the hand. After 10 months of active work to adapt this system to intracardiac surgery, the first open heart operation using computer assisted instruments was carried out on a 52-year-old woman presenting an aneurysm and a large defect of the atrial septum. The patient was extubated 8 h after the operation, returned to her room 16 h later and was discharged from the hospital 8 d post-operatively with normal heart function and no residual shunt. This preliminary experience showed that computer assisted cardiac surgery is feasible and may open new and promising directions in open heart surgery.


Subject(s)
Cardiac Surgical Procedures , Heart Aneurysm/surgery , Heart Septal Defects, Atrial/surgery , Therapy, Computer-Assisted , Female , Heart Septum , Humans , Middle Aged , Treatment Outcome
3.
C R Acad Sci III ; 319(3): 219-23, 1996 Mar.
Article in French | MEDLINE | ID: mdl-8761668

ABSTRACT

The development of "less invasive surgery" using small incisions and videoscopic techniques may change, in the near future, our attitude towards "traditional" surgery. This is because of specific advantages such as skin limited incisions, reduced perioperative disability and lower cost. Up to now, only abdominal, thoracic and coronary artery surgery which do not imply the opening of the heart, or closure of simple atrial septal defects, have benefitted from this new approach. This article reports the first case of open heart surgery for complex lesions of the left heart through a minithoracotomy (5 x 4 cm) with the use of videotransmission and peripheral extracorporeal circulation. The patient, a 30-year-old female, was operated upon for a combined mitral valve stenosis and insufficiency of rheumatic origin unsuccessfully treated by a previous percutaneous valve dilatation. The 2.5 h open heart procedure comprised commissurotomy, repair of torn leaflets, chordal transposition and Carpentier-Edwards prosthetic ring implantation. The patient left the hospital 12 days after the operation. Transesophageal echocardiography at discharge showed normal valve function with no residual stenosis or residual leak.


Subject(s)
Catheterization/methods , Heart Valve Prosthesis/methods , Mitral Valve/surgery , Thoracotomy/methods , Video Recording , Adult , Female , Humans , Mitral Valve Insufficiency/complications , Mitral Valve Insufficiency/therapy , Mitral Valve Stenosis/complications , Mitral Valve Stenosis/therapy , Treatment Outcome
4.
Arch Mal Coeur Vaiss ; 87(1): 49-56, 1994 Jan.
Article in French | MEDLINE | ID: mdl-7811151

ABSTRACT

Cardiomyoplasty (CMP) is a technique of circulatory assistance using a pediculated latissimus dorsi muscle wrapped around the heart and electrically stimulated during systole. Sixty-four patients, aged 15 to 69 years (average 50.8 +/- 13 years) with cardiac failure underwent CMP between January 1985 and July 1993. The causes of cardiac failure were : ischaemic heart disease (39 cases), dilated cardiomyopathy (18 cases), cardiomyopathy following valvular heart disease (2 cases), cardiac tumours (4 cases) and congenital heart disease (1 case). Twenty-four patients underwent an associated surgical procedure. Intra and postoperative intra-aortic balloon pumping was required in 27 cases. Hospital mortality (before latissimus dorsi stimulation) was 20.3% (13/64 cases). Evaluation of the survivors 12 months after surgery showed an improvement in functional class (1.,5 versus 3.3 before CMP ; p < 0.05), in isotopic ejection fraction (27 +/- 3% versus 17 +/- 6%, p < 0.05) and cardiac index (2.87 +/- 0.63 l/min/m2 versus 2.38 +/- 0.41 l/min/m2, p < 0.05). There was no significant change in cardiac filling pressures. The number of hospital admissions for congestive cardiac failure in operated patients was 0.4 per patient per year, compared with 2.5 per patient per year (p < 0.05) before CMP. The preoperative predictive factors for late mortality were: permanent functional Class IV (NYHA), severe cardiac dilatation (cardio-thoracic ratio greater than 0.60; left ventricular end diastolic dimension > 75 mm), an isotopic left ventricular ejection fraction < 15%, severe biventricular cardiac failure and irreversible pulmonary hypertension. The actuarial 4 year survival rate was 68.3%.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Cardiomyoplasty , Heart Failure/surgery , Actuarial Analysis , Adolescent , Adult , Aged , Electric Stimulation , Female , Follow-Up Studies , Heart Diseases/complications , Heart Diseases/surgery , Humans , Male , Middle Aged
5.
J Thorac Cardiovasc Surg ; 106(1): 42-52; discussion 52-4, 1993 Jul.
Article in English | MEDLINE | ID: mdl-8321004

ABSTRACT

Since January 1985, the date of the first dynamic cardiomyoplasty, until April 1992, 52 patients with end-stage heart disease were operated on in our institution. Mean preoperative New York Heart Association functional class was 3.3 and ventricular ejection fraction 16% +/- 3%. Associated procedures in 23 patients comprised ventricular aneurysm resection (10), valve surgery (9), coronary artery bypass (8), and tumor resection (3). Thirty-eight patients had a ventricular reinforcement, 13 a ventricular substitution, and 1 an atrial reinforcement using the left latissimus dorsi muscle. Preassist mortality rate before full latissimus dorsi muscle stimulation was 7 of 13 patients (54%) in the 1985 to 1987 period and 5 of 39 (12%) in the 1988 to 1992 period. The causes of death were heart failure (4), multiorgan failure (4), septicemia (2), ventricular fibrillation (1), and sudden death (1). Multivariate analysis of factors influencing hospital mortality showed that age, cardiac suture technique, associated surgical procedures, biventricular heart failure, and hemodynamic instability plus inotropic drug support were predictors of unfavorable outcome. All patients were followed up for from 2 months to 7 years (mean 21 months). Postassist mortality rate was 8 of 40 (20%). Causes of death included heart failure (5), ventricular fibrillation (1), myocardial infarction (1), and gastric bleeding (1). Preoperative risk factors influencing long-term mortality were permanent New York Heart Association functional class IV, biventricular heart failure, atrial fibrillation, cardiothoracic ratio greater than 60%, and ejection fraction less than 15%. Actuarial survival at 7 years was 70.4% (preassist mortality excluded). Surviving patients were in a mean New York Heart Association functional class of 1.8 (preoperatively 3.3, p < 0.05). The average ejection fractions (rest/stress) were 25%/28% at 1 year, 26%/30% at 2 years, and 23%/28% at 3 years. Average cardiothoracic ratios were 57% +/- 3% at 1 year, 56% +/- 2% at 2 years, and 57% +/- 2.5% at 3 years. Catheterization obtained in 20 patients showed no significant changes at rest in capillary wedge pressure, pulmonary artery pressure, and diastolic left ventricular pressure when compared with preoperative pressures. Average ejection fractions increased from 24% to 30.6%. Maximal oxygen consumption increased from 12.8 +/- 3.5 to 18.6 +/- 4 ml/min per kilogram. The number of rehospitalizations resulting from congestive heart failure was reduced to 0.4 hospitalizations per patient per year (preoperatively 2.4, p < 0.05). In 62% of the patients, pharmacologic therapy was diminished after the operation. Three patients required orthotopic heart transplantation 6 months, 4 years, and 5 years after cardiomyoplasty.


Subject(s)
Assisted Circulation/methods , Heart Failure/surgery , Surgical Flaps/methods , Actuarial Analysis , Adolescent , Adult , Aged , Cardiomyopathy, Dilated/complications , Contraindications , Electric Stimulation , Female , Follow-Up Studies , Heart Failure/etiology , Heart Failure/mortality , Heart Failure/physiopathology , Heart Neoplasms/complications , Hemodynamics , Humans , Male , Middle Aged , Myocardial Ischemia/complications , Postoperative Complications/mortality , Survival Rate , Treatment Outcome
6.
Eur J Cardiothorac Surg ; 6(12): 642-7; discussion 647-8, 1992.
Article in English | MEDLINE | ID: mdl-1485974

ABSTRACT

The principle of cardiomyoplasty is long-term electrostimulation of a latissimus dorsi muscle (LDM) wrapped around the failing heart. Technically, this procedure consists of placing the left LDM flap around the heart via a window created by partial resection of the 2nd or 3rd rib, and subsequent muscle electrostimulation in synchrony with ventricular systole. The aim of cardiomyoplasty is to support ventricular function in ischemic or dilated cardiomyopathies, or to partially replace the ventricular myocardium after large aneurysm or tumor resections. Our clinical experience at Broussais Hospital involves 44 patients. The functional class and quality of life improved after cardiomyoplasty. Improvement of the ventricular performance and limitation of cardiac dilatation were demonstrated over the long-term. The actuarial survival at 6 years was 71%. Risk factors influencing perioperative mortality were: age > 65 years, associated surgical procedures, pulmonary vascular hypertension, and patients hemodynamically unstable or on inotropic drug support. Preoperative risk factors influencing the long-term mortality were: permanent NYHA functional class 4, cardiothoracic ratio > 0.60, LV ejection fraction < 15%, bi-ventricular heart failure, and atrial fibrillation. Cardiomyoplasty does not preclude the use of future orthotopic heart transplantation.


Subject(s)
Heart Failure/surgery , Muscles/transplantation , Adolescent , Adult , Aged , Cardiac Output/physiology , Female , Follow-Up Studies , Heart Failure/mortality , Heart Failure/physiopathology , Hemodynamics/physiology , Hospital Mortality , Humans , Male , Middle Aged , Muscles/physiology , Myocardial Contraction/physiology , Pacemaker, Artificial , Postoperative Complications/mortality , Postoperative Complications/physiopathology , Postoperative Complications/surgery , Survival Rate , Suture Techniques
7.
Presse Med ; 20(27): 1273-4, 1991.
Article in French | MEDLINE | ID: mdl-1832762

ABSTRACT

This technique is original in that it involves a single site (the ascending aorta) easily accessible to cannulation. Following lateral clamping of the ascending aorta, a bifurcate Dacron prosthesis is anastomosed. The draining cannula is introduced through one of the branches of the prosthesis and manually guided through the aortic sigmoid leaflets down to the left ventricular ejection outlet. The perfusion cannula is introduced through the outer branch of the prosthesis. The end of this cannula is positioned at the origin of the prosthesis to avoid a possible bend in the fork. This technique is a simple and effective means of providing left ventricular support.


Subject(s)
Aortic Valve/surgery , Heart Ventricles/surgery , Heart-Assist Devices , Anastomosis, Surgical/methods , Humans
8.
Arch Mal Coeur Vaiss ; 82(1): 81-6, 1989 Jan.
Article in French | MEDLINE | ID: mdl-2494974

ABSTRACT

Right ventricular failure is relatively frequent and constitutes one of the causes of post-operative heart failure. Few drugs are available to treat right ventricular failure. We present a simple and effective means of mechanical support available in all cardiovascular units: counterpulsation in the pulmonary artery. Our experience and a review of the literature have enabled us to determine the indications for this method to support a failing heart.


Subject(s)
Assisted Circulation/methods , Heart Failure/therapy , Heart-Assist Devices/methods , Pulmonary Artery , Female , Heart Failure/physiopathology , Hemodynamics , Humans , Intra-Aortic Balloon Pumping , Middle Aged
9.
J Thorac Cardiovasc Surg ; 96(1): 92-101, 1988 Jul.
Article in English | MEDLINE | ID: mdl-3386297

ABSTRACT

Ebstein's anomaly is a complex malformation involving the tricuspid valve and the right ventricle. Various surgical techniques, either repair or replacement of the abnormal tricuspid valve, have been used with variable results. In an attempt to enlarge the indications of conservative procedures, we developed a technique of repair that comprises the reconstruction of a normally shaped right ventricle and the repositioning of the tricuspid valve at the normal level. In a series of 14 patients operated on between January 1980 and December 1986 in our institution, only one patient with an associated atrioventricular septal defect required a tricuspid valve replacement. All of the other patients, regardless of the complexity of the tricuspid malformation, were able to benefit from this conservative technique. There were two hospital deaths and no late deaths in this series. All surviving patients displayed a marked improvement over their preoperative status with regard to functional class (92% are in class I or II) and rhythm disturbances. Echocardiographic and Doppler studies demonstrated a normal shape of the right ventricle and good tricuspid valve function in all the patients but one.


Subject(s)
Ebstein Anomaly/surgery , Tricuspid Valve/surgery , Adult , Child , Ebstein Anomaly/physiopathology , Echocardiography , Female , Heart/physiopathology , Heart Ventricles/surgery , Humans , Male , Methods , Middle Aged
10.
Arch Mal Coeur Vaiss ; 79(13): 1851-7, 1986 Dec.
Article in French | MEDLINE | ID: mdl-3105498

ABSTRACT

The haemorrhagic complications inherent to the use of heparin during cardiac surgery led us, after a pilot experimental study, to try out a low molecular weight heparin (LMWH), PK 10169, which has weaker haemorrhagic effects in vitro. Our initial experience was confined to 23 patients with differing pathologies, undergoing cardiopulmonary bypass lasting 30 to 165 minutes. The modes of injection of YK 10169 varied according to the results, especially with respect to the limitation of peaks of anti-Xa activity; 8 patients were given one bolus intravenous injection, 9 were given a bolus injection and a continuous infusion, and 6 were only given the continuous infusion. Biological monitoring of anticoagulation was based on anti-Xa activity. Analysis of the biological results showed that the principal feature was the partial correction, and occasionally the non-correction of anti-Xa activity by protamine sulphate, with no correlation between this anti-Xa activity and postoperative bleeding. The authors report cases of severe postoperative bleeding despite the supposed theoretical and experimental weakly haemorrhagic properties of LMWH, and also discuss the inefficacy of protamine sulphate. The indications for LMWH for cardiopulmonary bypass which were retained, were the rare cases of heparin-induced thrombocytopaenia. In conclusion, it is possible to use LMWH during cardiac surgery but we do not advise using it routinely as its theoretical advantages are not confirmed in practice.


Subject(s)
Extracorporeal Circulation , Hemorrhage/chemically induced , Heparin/therapeutic use , Adolescent , Adult , Blood Coagulation Tests , Extracorporeal Circulation/adverse effects , Female , Hemostasis, Surgical , Heparin/adverse effects , Humans , Male , Middle Aged , Protamines/therapeutic use
11.
Haemostasis ; 16(2): 139-46, 1986.
Article in English | MEDLINE | ID: mdl-3710291

ABSTRACT

Neutralization of a low molecular weight (LMW) heparin fraction by protamine sulfate was evaluated in vitro and in vivo. Anti-Xa and anti-IIa activities were measured by amidolytic and coagulation methods (activated partial thromboplastin time, APTT). Fifteen patients (4 males and 11 females) underwent surgery with extracorporeal circulation. In vitro, anti-Xa and anti-IIa activities and APTT of unfractionated heparin were neutralized with a protamine/heparin (P/H) gravimetric ratio of 1.6, 1.33 and about 2, respectively. Anti-IIa activity and APTT induced by PK 10169 were completely corrected at a P/H ratio of 1 and 2, respectively, while anti-Xa activity was incompletely neutralized at a ratio of 5. In vivo, in 9 patients who did not receive intravenous protamine sulfate, a good correlation was found between doses of PK 10169 infused, anti-IIa plasma level and blood loss. In 3 patients who were treated prophylactically with protamine, bleeding was normal or only slightly increased. In 3 patients who received protamine because of hemorrhage, mean anti-Xa and anti-IIa were 2.3 and 0.54 U before and 1.32-0.06 U after neutralization. Bleeding was stopped by a second dose of protamine in 1 patient, but blood loss was abnormal in the other patients. However, a correlation between bleeding and anti-Xa or anti-IIa activities was not clearly evident.


Subject(s)
Factor X/antagonists & inhibitors , Heparin Antagonists , Heparin/pharmacology , Protamines/pharmacology , Adolescent , Adult , Blood Coagulation/drug effects , Extracorporeal Circulation , Factor Xa , Female , Humans , In Vitro Techniques , Male , Middle Aged , Molecular Weight , Partial Thromboplastin Time
13.
Arch Mal Coeur Vaiss ; 77(10): 1146-50, 1984 Oct.
Article in French | MEDLINE | ID: mdl-6439153

ABSTRACT

The incidence of acute suppurative mediastinitis after open heart cardiac surgery in a 5 year retrospective study was found to be 1.56%. The commonest causal agent was the DNAse + coagulase + staphylococcus (68.8%). All cases were treated with bactericidal antibiotics and local measures (dosed chest irrigation-drainage in 1 or 2 stages). Adult men, early and/or late reoperation, immediate postoperative complications (cardiovascular collapse, haemorrhage) were positive risk factors. On the other hand, the type of underlying cardiac disease, the duration of surgery and bypass time, emergency surgery, and protocols of prophylactic antibiotic therapy did not seem to influence this risk. No sources of exogenous contamination, no notions of epidemics or periodicity were discovered in this study. The clinical course may be complicated, especially by renal failure. Thirty-two of the 109 patients studied died. However, the prognosis has improved in the last 5 years in relation to technical advances in intensive care and, above all, to adoption of 1 stage dosed chest irrigation-drainage: the mortality rate has fallen from 37.2% in the first period to 20% more recently. When a cure is obtained, it is complete and there are no sequellae. Nevertheless, irrespective of the adoption of draconian measures of asepsis and protocols of prophylactic antibiotic therapy, the risk of acute postoperative mediastinitis persists. This suggests that the efficacy of the patient's local (and general) anti-infective immunity defenses may vary in the presence of constant mediastinal bacterial contamination despite aleatory preventive measures, due to the remenance of the skin flora.


Subject(s)
Cardiac Surgical Procedures/adverse effects , Extracorporeal Circulation/adverse effects , Mediastinitis/etiology , Surgical Wound Infection/etiology , Acute Disease , Adult , Anti-Bacterial Agents/therapeutic use , Combined Modality Therapy , Female , Humans , Male , Mediastinitis/epidemiology , Mediastinitis/therapy , Premedication , Prognosis , Reoperation , Retrospective Studies , Risk , Staphylococcal Infections/epidemiology
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