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3.
Rev Infect Dis ; 6 Suppl 4: S844-6, 1984.
Article in English | MEDLINE | ID: mdl-6395274

ABSTRACT

Fifty-three women with symptoms of lower urinary tract infection were randomly assigned to treatment with cefonicid administered intramuscularly in a single 1-g dose or to treatment with 500 mg of amoxicillin administered orally three times a day for five to seven days. Urine cultures were obtained before therapy and again at five to 18 days and six to seven weeks after termination of therapy. Forty-one patients had greater than or equal to 2 X 10(4) colony-forming units (cfu)/ml of catheterized urine or greater than or equal to 10(5) cfu/ml of midstream urine. In the cefonicid-treated group, 19 (90%) of 21 patients demonstrated bacteriologic cure at early follow-up. Of the 18 patients seen at late follow-up, 15 were cured and three were reinfected. One patient was lost to late follow-up. In the amoxicillin-treated group, 16 (80%) of 20 patients demonstrated bacteriologic cure at early follow-up. Of the 15 patients available at late follow-up, 14 were cured and one was reinfected. One patient was lost to late follow-up. Cefonicid is an effective single-dose agent in uncomplicated lower urinary tract infection.


Subject(s)
Cefamandole/analogs & derivatives , Enterobacteriaceae Infections/drug therapy , Urinary Tract Infections/drug therapy , Adult , Aged , Amoxicillin/administration & dosage , Amoxicillin/therapeutic use , Cefamandole/administration & dosage , Cefamandole/therapeutic use , Cefonicid , Clinical Trials as Topic , Female , Follow-Up Studies , Half-Life , Humans , Middle Aged , Random Allocation , Time Factors
4.
J Urol ; 130(3): 445-8, 1983 Sep.
Article in English | MEDLINE | ID: mdl-6887353

ABSTRACT

We reviewed 161 patients operated upon for renal cell carcinoma between 1945 and 1978. Life table and survival analyses were computed to compare the effects of stage, tumor differentiation, cell type, surgical technique, renal vein involvement and sex on the years of survival. Patients with stage I and well differentiated tumors had the best prognosis. All patients surviving 10 years or more had well differentiated tumors. The type of nephrectomy did not affect survival and lymphadenectomy was only of value in staging the disease. The stage and differentiation of the tumor were more important to outcome than choice of therapy.


Subject(s)
Adenocarcinoma/diagnosis , Kidney Neoplasms/diagnosis , Adenocarcinoma/mortality , Adenocarcinoma/surgery , Adult , Aged , Humans , Kidney Neoplasms/mortality , Kidney Neoplasms/surgery , Middle Aged
7.
Urology ; 11(2): 175-8, 1978 Feb.
Article in English | MEDLINE | ID: mdl-628997

ABSTRACT

We believe that the probable "estrogen-free" site which is present in the liver while a patient is on estrogens gives a conductive environment for local growth of prostate malignancy. We report 1 patient who improved with local irradiation and 2 others who stabilized and symptomatically improved with chemotherapy. Hopefully, future reports will shed more light on the treatment of hepatic metastases from prostatic adenocarcinoma.


Subject(s)
Adenocarcinoma/drug therapy , Diethylstilbestrol/pharmacology , Liver/drug effects , Prostatic Neoplasms/drug therapy , Aged , Diethylstilbestrol/therapeutic use , Humans , Liver Neoplasms/pathology , Liver Neoplasms/therapy , Male , Middle Aged , Neoplasm Metastasis
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