1.
Bioorg Med Chem Lett
; 15(15): 3609-10, 2005 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-15967662
ABSTRACT
We have developed a concise synthesis of dielsiquinone 1, a potent cytotoxic agent related to anthraquinones. Electrochemical studies have shown that dielsiquinone is reduced to a semiquinone radical that does not react with O2 to generate toxic reactive oxygen species. These results strongly suggest that 1 should be less cardiotoxic than anthracyclines used in clinic and may therefore provide the basis for the development of safer anticancer drugs.