Nurse middle managers' proactive work behavior: antecedents and consequences on innovative work behavior and job performance.

PURPOSE: Healthcare organizations require more proactive behaviors from nursing professionals. However, nurse managers' proactivity has rarely been analyzed in the literature and little is known about the antecedents and consequences of their proactive behavior at work. This study examines the relationships between job characteristics (i.e. job autonomy and job variety), psychological empowerment, proactive work behavior and job effectiveness indicators (i.e. innovative work behavior, job performance). We tested a model in which psychological empowerment and proactive work behavior sequentially mediate the relationship between job characteristics and job effectiveness. DESIGN/METHODOLOGY/APPROACH: A cross-sectional study was conducted among nurse middle managers from a French hospital (N = 321). A hypothetical model was developed based on existing theory. Structural equation modeling was used to test the hypotheses. FINDINGS: Results show that psychological empowerment and proactive work behavior fully mediate the relationship between job characteristics and innovative work behavior, and partially mediate the relationship between job characteristics and job performance. ORIGINALITY/VALUE: This study provides insights for understanding how job characteristics can contribute to fostering the proactivity of nurse middle managers and how their proactive work behavior can be positively related to innovative work behavior and job performance. Findings raise several implications for hospital administrators and upper management seeking new ways to enhance nurse middle managers' proactive work behavior and push further their effectiveness at work.

[Motivation for physical exercise: the benefits of active transport in the fight against sedentary lifestyles]. / Motivation à la pratique physique : intérêts des transports actifs pour lutter contre la sédentarité.

Our contemporary lifestyles offer little incentive to be physically active, and give us far fewer opportunities to be active than in the past, with many of our tasks being sedentary and most of our transport being motorized. While it's easy to acknowledge a lack of physical activity, putting it into practice is eminently more complex, and many researchers are trying to answer the thorny question: how can we enable people to be more physically active in their daily lives? With this in mind, the aim of this article is to show that active transport is an effective way of getting sedentary people to engage in regular physical activity.

[The benefits of physical activity in the workplace for maintaining employee health]. / Intérêts de l'activité physique au travail pour le maintien de la santé des salariés.

Some jobs, particularly in the service sector, involve little physical activity on the part of employees. To improve their health, several areas or periods could be used to increase the amount of daily physical activity. Active transport to and from work is one such initiative, but physical activity can also be envisaged outside and during working hours. The aim of this article is to provide insights and research perspectives to better measure the importance of physical activity in the workplace.

[High-level sports and anorexia nervosa]. / Pratiques sportives de haut niveau et anorexie mentale.

Due to intensive physical training, and the pressure exerted by coaches, parents and the athlete him/herself during pre-competitive and competitive periods, a large number of high-level sporting activities can trigger or participate in anorexia nervosa. That said, some of these activities are more likely than others to promote this eating disorder. It is worth highlighting the sports most at risk for the onset or development of anorexia nervosa, and then addressing the means of prevention and regulation adapted to these circumstances.

[Impact of adapted physical activities on the health and psychological factors involved in the learning of pupils and students]. / Impacts des APA sur les facteurs psychologiques impliqués dans les apprentissages des élèves et des étudiants.

The literature documenting the positive role of adapted physical activities (APA) in academic success is flourishing. It's widely accepted that practicing APA helps you succeed. However, the pathway linking the impact of physical activity on student health to academic success remains unclear, and there is still a great deal of ground to cover. With this in mind, the aim of this article is to review what is known about the health benefits of physical activity and the psychological factors involved in learning in the school and university context.

[Preventing and regulating psychoactive substance use among occasional and regular adolescents]. / Prévenir et réguler la consommation de substances psychoactives chez les adolescents.

The academic success and well-being of young people can be undermined by the use of psychoactive substances (PAS), which is particularly prevalent during adolescence, a period vulnerable to social influences. This article is aimed in particular at school and university preventive medicine nurses. It proposes intervention strategies for adolescents who regularly use such substances. Based on the scientific literature, the aim is to examine how psychological support, coupled with a program of adapted physical activity, could limit the use of APS, a factor in academic failure and health risks.

[Analysis of the psychological causes of early substance use among adolescents in school and university settings]. / Analyse des causes psychologiques des premières consommations de substances psychoactives chez les adolescents en contexte scolaire et universitaire.

Experimentation with psychoactive substances (PAS), such as alcohol, tobacco or cannabis, is common in adolescence, and continues to pose a public health issue that can lead to failure at school and university. Most of the work on these issues focuses on addiction-related aspects, and little on the underlying causes of addiction. This article sheds psycho-social theoretical light on the causes of first-time use of APS, and cannabis in particular. It is particularly aimed at school nurses and university preventive medicine nurses.

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.

Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-containing phagosomes, and Gal-3 and Gal-8 are reported to restrict bacterial growth via autophagy in cultured cells. However, the contribution of these galectins to host resistance during bacterial infection in vivo remains unclear. We found that Gal-9 binds directly to Mycobacterium tuberculosis (Mtb) and Salmonella enterica serovar Typhimurium (Stm) and localizes to Mtb in macrophages. To determine the combined contribution of membrane damage-sensing galectins to immunity, we generated Gal-3, -8, and -9 triple knockout (TKO) mice. Mtb infection of primary macrophages from TKO mice resulted in defective autophagic flux but normal bacterial replication. Surprisingly, these mice had no discernable defect in resistance to acute infection with Mtb, Stm or Listeria monocytogenes, and had only modest impairments in bacterial growth restriction and CD4 T cell activation during chronic Mtb infection. Collectively, these findings indicate that while Gal-3, -8, and -9 respond to an array of intracellular pathogens, together these membrane damage-sensing galectins play a limited role in host resistance to bacterial infection.

[Health care workers: the importance of adapted physical activities]. / Santé des personnels soignants : l'importance des activités physiques adaptées.

Adapted physical activities (APA) in the workplace improve workers' health. Paradoxically, APA remains marginal in the very places where improving health is the central objective of health care workers, namely clinics and hospitals. Promoting physical activity in the workplace is a twofold challenge. Not only does PA improve the health and well-being of caregivers, but it also allows them to be more effective in their daily work with patients.

Autophagy restricts Mycobacterium tuberculosis during acute infection in mice.

Whether or not autophagy has a role in defence against Mycobacterium tuberculosis infection remains unresolved. Previously, conditional knockdown of the core autophagy component ATG5 in myeloid cells was reported to confer extreme susceptibility to M. tuberculosis in mice, whereas depletion of other autophagy factors had no effect on infection. We show that doubling cre gene dosage to more robustly deplete ATG16L1 or ATG7 resulted in increased M. tuberculosis growth and host susceptibility in mice, although ATG5-depleted mice are more sensitive than ATG16L1- or ATG7-depleted mice. We imaged individual macrophages infected with M. tuberculosis and identified a shift from apoptosis to rapid necrosis in autophagy-depleted cells. This effect was dependent on phagosome permeabilization by M. tuberculosis. We monitored infected cells by electron microscopy, showing that autophagy protects the host macrophage by partially reducing mycobacterial access to the cytosol. We conclude that autophagy has an important role in defence against M. tuberculosis in mammals.

[Interest of the adapted physical activities for the staff of the penitentiary administration]. / Intérêt des activités physiques adaptées pour les personnels de l'administration pénitentiaire.

The poor state of health of some prisoners, the tensions and violence that can exist in prisons lead the administration's staff to work in a sometimes difficult context. The regular practice of adapted physical activities appears to be a particularly opportune course of action for the agents concerned: it would bring them physical and psychological benefits in their professional exercise.

Translation and validation of the movement imagery questionnaire-3 second French version.

INTRODUCTION: Motor imagery (MI) can be defined as the mental simulation of an action without performing it. Its effectiveness can be substantially influenced by imagery ability, and it is currently accepted that three main modalities are used in MI (kinaesthetic imagery, and internal or external visual imageries). In the context of rehabilitation, MI combined with physical therapy is further known to facilitate functional improvements, and promote cortical reorganization and long-term recovery. This study aimed to test the reproducibility and the validity of constructs (internal consistency and factorial structure) of the Movement Imagery Questionnaire-3 Second French version (MIQ-3Sf). METHOD: The internal consistency as well as the validity of constructs and the test-retest inter-rate reproducibility of the MIQ-3Sf was examined, in 553 participants, for the kinaesthetic and visual items. RESULTS: The composite reliability scores (≥0.92) and the intraclass correlation coefficients (>0.88) for the kinaesthetic, internal visual and external visual imagery subscales revealed satisfactory internal consistency and reproducibility. Moreover, Pearson correlations revealed a strong relationship between the MIQ-3Sf and the MIQ-3f. CONCLUSIONS: /Implications. The MIQ-3Sf can be considered as a valid, reliable and useful questionnaire for examining MI ability in the context of rehabilitation.

Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.

Decontaminating N95 respirators for reuse could mitigate shortages during the COVID-19 pandemic. Although the United States Center for Disease Control has identified Ultraviolet-C irradiation as one of the most promising methods for N95 decontamination, very few studies have evaluated the efficacy of Ultraviolet-C for SARS-CoV-2 inactivation. In addition, most decontamination studies are performed using mask coupons that do not recapitulate the complexity of whole masks. We sought to directly evaluate the efficacy of Ultraviolet-C mediated inactivation of SARS-CoV-2 on N95 respirators. To that end we created a portable UV-C light-emitting diode disinfection chamber and tested decontamination of SARS-CoV-2 at different sites on two models of N95 respirator. We found that decontamination efficacy depends on mask model, material and location of the contamination on the mask. Our results emphasize the need for caution when interpreting efficacy data of UV-C decontamination methods.

Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has emerged as a major global health threat. The COVID-19 pandemic has resulted in over 168 million cases and 3.4 million deaths to date, while the number of cases continues to rise. With limited therapeutic options, the identification of safe and effective therapeutics is urgently needed. The repurposing of known clinical compounds holds the potential for rapid identification of drugs effective against SARS-CoV-2. Here, we utilized a library of FDA-approved and well-studied preclinical and clinical compounds to screen for antivirals against SARS-CoV-2 in human pulmonary epithelial cells. We identified 13 compounds that exhibit potent antiviral activity across multiple orthogonal assays. Hits include known antivirals, compounds with anti-inflammatory activity, and compounds targeting host pathways such as kinases and proteases critical for SARS-CoV-2 replication. We identified seven compounds not previously reported to have activity against SARS-CoV-2, including B02, a human RAD51 inhibitor. We further demonstrated that B02 exhibits synergy with remdesivir, the only antiviral approved by the FDA to treat COVID-19, highlighting the potential for combination therapy. Taken together, our comparative compound screening strategy highlights the potential of drug repurposing screens to identify novel starting points for development of effective antiviral mono- or combination therapies to treat COVID-19.

Face Cooling During Swimming Training in Tropical Condition.

The aim of this study was to test the effect of face cooling with cold water (1.2 ± 0.7°C) vs. face cooling with neutral water (28.0 ± 3.0°C) during high-intensity swimming training on both the core temperature (Tco) and thermal perceptions in internationally ranked long-distance swimmers (5 men's and 3 women's) during 2 randomized swimming sessions. After a standardized warm-up of 1,200 m, the athletes performed a standardized training session that consisted of 2,000 m (5 × 400 m; start every 5'15") at a best velocity then 600 m of aerobic work. Heart rate (HR) was continuously monitored during 5 × 400 m, whereas Tco, thermal comfort (TC), and thermal sensation (TS) were measured before and after each 400 m. Before and after each 400 m, the swimmers were asked to flow 200 mL of cold water (1.2°C) or neutral (22°C) water packaged in standardized bottles on their face. The swimmers were asked don't drink during exercise. The velocity was significantly different between cold water and neutral water (p < 0.004 - 71.58 m.min-1 ± 2.32 and 70.52 m.min-1 ± 1.73, respectively). The Tco was increased by ±0.5°C at race pace, under both face cooling conditions with no significant difference. No significant changes were noted in mean HR (i.e., 115 ± 9 and 114 ± 15 bpm for NW and CW, respectively). TC was higher with Cold Cooling than Neutral Cooling and TS was lower with Cold cooling compared with Neutral cooling. The changes in perceptual parameters caused by face cooling with cold water reflect the psychological impact on the physical parameters. The mean velocity was less important with face cooling whereas the heat rate and Tco were the same in the both conditions. The mechanism leading to these results seems to involve brain integration of signals from physiological and psychological sources.

From Feedback Seeking to Psychological Attachment, the Mediating Role of Adaptive Performance in Perceived Obstruction Context.

Based on proactivity literature, feedback seeking behavior is generally used throughout an individual's career to enable better adaptation to the work environment. However, it has recently been shown that declining levels of feedback seeking behavior may result in decreased psychological attachment over time. This study aims to explore whether individual adaptivity represents a mechanism through which feed-back seeking affects psychological attachment (i.e., well-being involvement and withdrawal). In addition, the interaction effect of organizational obstruction between individual adaptivity and psychological attachment was examined. Based on three-wave survey data obtained from 273 participants from French organizations, a moderated mediation model was tested using structural equation modeling. Results confirmed that adaptive performance mediated positively the relationship between feedback-seeking and well-being involvement and negatively with withdrawal. Moreover, perceived organizational obstruction moderated negatively the relationship between adaptive performance and withdrawal, and positively that with well-being. These results shed new light on the relationship between proactivity (i.e., feedback seeking behavior) and adaptive performance, but also on the positive short-term contribution of successful adaptation in a perceived obstructive organizational context. Theoretical contributions and practical implications for human resource management are discussed.

An Innovative Biological Model for Ultrasound-Guided Central Venous Access Simulation.

INTRODUCTION: Simulation training is an increasingly used method to train medical students in the use of ultrasound guidance for vascular access positioning. Although very efficient for basic training, commercial simulators for vascular access do not reproduce real-life conditions. We developed a biological training model, using porcine liver, and compared it with an existing commercial model. METHODS: Whole porcine livers were used by perfusing the portal vein system after inferior vena cava clamping. Thirty-three practitioners accustomed to ultrasound-guided procedure were enrolled to perform an ultrasound-guided vascular procedure on both biological and commercial models. Procedure duration was recorded and 10-point scales were used to compare the 2 models regarding image quality, procedure feeling, and similarity with the real-life procedure. RESULTS: Participants reported a better image quality with the biological model (8.8 ± 1 vs. 7.7 ± 2, P = 0.007) as well as a significant difference in the procedure feeling (8.0 ± 1 vs. 6.9 ± 1.9, P = 0.002). Real-life likeness was significantly better for the biological model (8.4 ± 1.1 vs. 4.5 ± 6, P < 0.0001). Procedure duration was almost 3 times longer using the biological model than the commercial model (209.6 ± 189.0 vs. 59.8 ± 50.1, P < 0.0001). CONCLUSIONS: This study validates our biological model of porcine's liver as an interesting training model, allowing closer real-life perception than its commercial counterpart. This model could complement and enhance simulation learning.