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BMJ Case Rep ; 20162016 Mar 01.
Article in English | MEDLINE | ID: mdl-26933184

ABSTRACT

Sunitinib is a tyrosine kinase inhibitor that is used as an anticancer drug in renal cell carcinoma (RCC), pancreatic neuroendocrine tumours (PNETs) and gastrointestinal stromal tumour. Elevated liver enzymes are frequently observed during treatment but acute liver failure is uncommon. We describe a case of fulminant acute liver failure and acute kidney injury during treatment with sunitinib for metastatic RCC.


Subject(s)
Acute Kidney Injury/chemically induced , Indoles/adverse effects , Liver Failure, Acute/chemically induced , Protein Kinase Inhibitors/adverse effects , Pyrroles/adverse effects , Aged , Carcinoma, Renal Cell/drug therapy , Carcinoma, Renal Cell/pathology , Fatal Outcome , Humans , Indoles/therapeutic use , Kidney Neoplasms/drug therapy , Kidney Neoplasms/pathology , Male , Neoplasm Metastasis , Protein Kinase Inhibitors/therapeutic use , Pyrroles/therapeutic use , Sunitinib
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