Subject(s)
Antibodies, Monoclonal, Humanized/therapeutic use , Carcinoma, Squamous Cell/drug therapy , Interleukin-17/antagonists & inhibitors , Laryngeal Neoplasms/drug therapy , Psoriasis/drug therapy , Antineoplastic Agents/therapeutic use , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/diagnostic imaging , Carcinoma, Squamous Cell/radiotherapy , Humans , Laryngeal Neoplasms/complications , Laryngeal Neoplasms/diagnostic imaging , Laryngeal Neoplasms/radiotherapy , Male , Middle Aged , Psoriasis/complications , Psoriasis/pathologySubject(s)
Humans , Female , Aged , Biopsy , Lymphoma, Large B-Cell, Diffuse/diagnosis , Skin , Vascular Neoplasms/diagnosis , Lymphoma, Non-HodgkinSubject(s)
Antiparkinson Agents/adverse effects , Carbidopa/adverse effects , Hyperpigmentation/chemically induced , Levodopa/adverse effects , Melanins/biosynthesis , Melanocytes/drug effects , Melanoma/diagnosis , Parkinson Disease/drug therapy , Skin Neoplasms/diagnosis , Skin Pigmentation/drug effects , Skin/drug effects , Aged , Diagnosis, Differential , Drug Combinations , Female , Humans , Hyperpigmentation/metabolism , Hyperpigmentation/pathology , Melanocytes/metabolism , Melanocytes/pathology , Melanoma/metabolism , Melanoma/pathology , Parkinson Disease/diagnosis , Predictive Value of Tests , Skin/metabolism , Skin/pathology , Skin Neoplasms/metabolism , Skin Neoplasms/pathology , Treatment OutcomeABSTRACT
Angiokeratoma circumscriptum is the rarest variant of angiokeratoma. It usually affects females and it is characterized by dark-red to blue-black confluent papules or nodules on lower limbs in a segmental and unilateral distribution. We describe the clinical and histopathological findings in a patient with angiokeratoma circumscriptum and discuss the etiology, associations, diagnosis, differential diagnosis, and treatment.
Subject(s)
Angiokeratoma/diagnosis , Skin Neoplasms/diagnosis , Adult , Angiokeratoma/congenital , Angiokeratoma/pathology , Diagnosis, Differential , Female , Humans , Lower Extremity , Skin Neoplasms/congenital , Skin Neoplasms/pathologyABSTRACT
Subcutaneous fat necrosis of the newborn is a rare lobular panniculitis. It is characteristic of term or post-term neonates with a history of perinatal compromise or maternal gestational pathology. The cutaneous manifestations consist of erythematous and indurated subcutaneous plaques and nodules located over the dorsal region and the shoulders. Diagnosis is clinical and pathological. Histopathological findings include lobular panniculitis with a lymphohistiocytic inflammatory infiltrate with few neutrophils, fatty necrosis, deposition of radial needle-shaped crystals in the adipocytes, and possible calcification and hemorrhage. The cutaneous ultrasound shows hyperechoic and avascular subcutaneous cellular tissue and acoustic shadows may appear corresponding to calcifications. The clinical differential diagnosis includes sclerema neonatorum and post-corticosteroid panniculitis. Histologically crystal-forming panniculitis conditions are in the differential diagnosis. The disease is usually self-limited but complications such as hypercalcemia, hypoglycemia, hypertriglyceridemia, thrombocytopenia, and anemia may occur. Complications should be ruled out and treated at diagnosis and during follow-up. The most important complication is hypercalcemia.La necrosis grasa subcutánea neonatal es una paniculitis lobulillar infrecuente. Es característica de neonatos a término o postérmino con antecedentes de sufrimiento perinatal o patología gestacional materna. Las manifestaciones cutáneas consisten en placas y nódulos subcutáneos eritematosos e indurados localizados preferentemente en la región dorsal y los hombros. El diagnóstico es clínicopatológico. Los hallazgos histopatológicos comprenden una paniculitis lobulillar con un infiltrado inflamatorio linfohistiocitario con escasos neutrófilos, necrosis grasa, depósito de cristales radiados en los adipocitos y posibles focos de calcificación y hemorragia. En la ecografía cutánea se observa hiperecogenicidad y avascularización del tejido celular subcutáneo y pueden aparecer sombras acústicas posteriores que se correspondencon calcificaciones. El diagnóstico diferencial clínico se debe realizar con el escleredema neonatorum y la paniculitis postesteroidea, e histológicamente con las paniculitis con formación de cristales. La enfermedad suele ser autolimitada pero pueden aparecer complicaciones como la hipercalcemia, la hipoglucemia, la hipertrigliceridemia, latrombocitopenia y la anemia. Las complicaciones deben ser descartadas y tratadas en el diagnóstico y durante el seguimiento. La complicación másimportante es la hipercalcemia.
