ABSTRACT
AIMS: The present study aimed to develop and evaluate a new dairy by-product nutritional supplement with Buriti fruit to improve malnutrition in mice and elderly woman. BACKGROUND: Malnutrition is a prevalent problem in the elderly; therefore, oral dietary supplementation is an important strategy to reduce this health problem incidence. OBJECTIVE: The present study evaluated the effects of a low-cost food supplement, made from byproducts of the dairy and fruit industry in the Brazilian Cerrado (Buriti), on the nutritional status and on the recovery of the metabolic profile of malnourished animals and elderly women. METHODS: In the pre-clinical phase, Swiss mice were divided into six groups and subjected to malnutrition and renutrition. The clinical phase was carried out with 25 elderly women residing in a long-term institution, aged ≥ 65 years and with malnutrition or risk of malnutrition. RESULTS: The main results showed improvements in anthropometric parameters and an increase in serum albumin levels, in addition to lipid profile improvement in the preclinical phase and an increase in the red blood cells and hemoglobin in the clinical phase. CONCLUSION: The supplement based on Buriti was able to reverse malnutrition promoting improvements in anthropometric and biochemical parameters.
Subject(s)
Arecaceae , Malnutrition , Aged , Animals , Brazil/epidemiology , Dietary Supplements , Female , Fruit , Humans , Malnutrition/diagnosis , Malnutrition/prevention & control , Mice , Nutritional StatusABSTRACT
BACKGROUND: Malnutrition induced by dietary restriction produces several metabolic changes that affect body weight, the digestive system, and annex organs, including the liver. Malnutrition generates an inflammatory state and increases oxidative stress. The liver is one of the body vital organs, becoming necessary to analyze the impact of food supplementation on the repair of possible changes that may occur in this organ due to malnutrition. AIMS: To evaluate the effects of a low-cost supplementation derived from Buriti and dairy byproducts on liver recovery in malnourished mice, focusing on the expression of oxidative stressrelated genes, as well as biochemical and histological parameters. METHODS: Swiss mice were divided into six groups and submitted to two treatment phases: food restriction, for malnutrition onset; and renutrition, with mice being fed with different diets. RESULTS: Our results indicate that dietary supplementation was successful in recovering liver damage caused by malnutrition in animal models. The new supplement has been shown to recover liver damage with similar or superior results compared to the commercial reference supplement on the market. CONCLUSION: Our work presents a new composition of low cost food supplement based on buriti and dairy by-products, proven to be effective in the malnutrition treatment of malnutrition. The improvements were proven through the recovery of body weight, reduction of inflammation and oxidative stress.
Subject(s)
Arecaceae/metabolism , Dairy Products/analysis , Liver Diseases/diet therapy , Liver/injuries , Malnutrition/complications , Animals , Arecaceae/chemistry , Body Weight , Dietary Supplements/analysis , Fruit/chemistry , Fruit/metabolism , Humans , Liver Diseases/etiology , Liver Diseases/metabolism , Liver Diseases/physiopathology , Male , Mice , Oxidative StressABSTRACT
BACKGROUND: Brazilian flora is rich in plants with medicinal properties, which though popular, has contributed to the development of a range of phytotherapic products that use plants to treat and cure diseases. However, studies that use Brazilian plants in the treatment of metabolic disorders are still scarce in the literature. OBJECTIVE: The aim of this study was to analyze the effect of hepatotoxicity Lafoensia pacari on the metabolism of mice with obesity induced by a high-fat diet and to verify the phytochemical difference between the Lafoensia pacari bark of the trunk, leaves, and branches. METHODS: The plant material was collected from April to May in the municipality of Bonito de Minas, MG, Brazil. Qualitative tests for the presence of secondary metabolite classes were performed for leaves, branches and bark of the trunk. Through histological analysis, we evaluated hepatocytes and cell lesions in the liver. RESULTS: The comparative phytochemical analysis of the plant did not reveal alterations between the different plant parts. The phytochemical test showed that is preferable to use the leaves to make the extract to be applied, aiming to reduce the plant aggression. After treatment, greater changes were observed in the animals that received the high-fat diet and the hydroethanolic extract; the levels of AST, ALT, albumin and creatinine that were increased, thus demonstrating a possible toxicity. There were no significant differences in body weight. In the histological analysis, the animals without plant treatment displayed decreased liver weight and reduction in the inflammatory infiltrate. CONCLUSION: We conclude that Lafoensia pacari should be better evaluated for oral consumption and may cause liver damage.
Subject(s)
Anti-Obesity Agents/toxicity , Liver/drug effects , Lythraceae/chemistry , Obesity/drug therapy , Plant Extracts/toxicity , Alanine Transaminase/metabolism , Albumins/metabolism , Alkaloids/isolation & purification , Alkaloids/toxicity , Animals , Anti-Obesity Agents/chemistry , Aspartate Aminotransferases/metabolism , Body Weight/drug effects , Brazil , Creatinine/metabolism , Diet, High-Fat/adverse effects , Flavonoids/isolation & purification , Flavonoids/toxicity , Glutathione Peroxidase/metabolism , Hepatocytes/drug effects , Hepatocytes/metabolism , Hepatocytes/pathology , Liver/metabolism , Liver/pathology , Male , Mice , Obesity/etiology , Obesity/metabolism , Obesity/pathology , Phenols/isolation & purification , Phenols/toxicity , Plant Bark/chemistry , Plant Extracts/chemistry , Plant Leaves/chemistry , Plant Stems/chemistry , Secondary Metabolism , Superoxide Dismutase/metabolism , Glutathione Peroxidase GPX1ABSTRACT
Objectives: It was evaluated epidemiological aspects of primary lip squamous cell carcinoma (LSCC) and its associationswith clinicopathological factors. Study design: This retrospective, cross-sectional study analysed a sociodemographic,clinical, and morphological data of HNSCC in a Brazilian population (n=30). Data analysis includeddescriptive statistics and bivariate analyses using the chi-square and Fishers exact tests to compare the variables.Results: The LSCC represented 10.8% of all oral cavity squamous cell carcinoma. Lip malignant disease was moreprevalent in elderly men, with male-to-female ratio of 5:1. Lower lip was more affected. It was observed high ratesof chronic solar exposure, and tobacco and alcohol drinking habits. Clinically, early TNM staging, small tumourlesions, and non-metastatic disease were predominant findings. It was identified a high frequency of well differentiatedtumor samples. Worse Karnofsky performance status was associated with cervical metastasis. Conclusions:Our findings showed that LSCC patients exhibited similar epidemiological and clinical profiles as noted in otherstudies. Still, the occurrence of metastatic disease was associated with a worse physical performance status of theLSCC patients during diagnosis (AU)
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