Transcultural adaptation of the user satisfaction scale to the health service: Brazilian version of the EORTC IN-PATSAT32 questionnaire

Objective: To describe the cross-cultural adaptation and psychometric properties of the Brazilian version of the IN-PATSAT32 questionnaire. Methods: The questionnaire was applied to 328 patients in a public hospital, and the retest was performed with 86 patients, approximately 1 week after the test. Psychometric analyses were performed to evaluate the structure, reliability, and internal consistency of the questionnaire. Results: The adapted questionnaire presented high sensitivity and the intraclass correlation coefficient (ICC > 8) indicated strong convergent validity and discriminant properties of the instrument, as well as high internal consistency (Cronbach’s α > 0.8). Exploratory factor analysis divided the questionnaire into five dimensions: satisfaction with a multidisciplinary team (α = 0.953, kp = 0.61, ICC = 0.953), doctors (α = 0.993, kp = 0.817, ICC = 0.966), therapeutic (α = 0.946, kp = 0.869, ICC = 0.972), hospital structure (α = 0.97, kp = 0.87, ICC = 0.947), and hospital discharge. Conclusion: The results indicated that the Brazilian version maintained its psychometric properties when used in a heterogeneous population and with different diagnoses and stages of treatment for cancer

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Longitudinal brain volumetric changes during one year in non-elderly healthy adults: a voxel-based morphometry study

Previous cross-sectional magnetic resonance imaging (MRI) studies of healthy aging in young adults have indicated the presence of significant inverse correlations between age and gray matter volumes, although not homogeneously across all brain regions. However, such cross-sectional studies have important limitations and there is a scarcity of detailed longitudinal MRI studies with repeated measures obtained in the same individuals in order to investigate regional gray matter changes during short periods of time in non-elderly healthy adults. In the present study, 52 healthy young adults aged 18 to 50 years (27 males and 25 females) were followed with repeated MRI acquisitions over approximately 15 months. Gray matter volumes were compared between the two times using voxel-based morphometry, with the prediction that volume changes would be detectable in the frontal lobe, temporal neocortex and hippocampus. Voxel-wise analyses showed significant (P < 0.05, family-wise error corrected) relative volume reductions of gray matter in two small foci located in the right orbitofrontal cortex and left hippocampus. Separate comparisons for males and females showed bilateral gray matter relative reductions in the orbitofrontal cortex over time only in males. We conclude that, in non-elderly healthy adults, subtle gray matter volume alterations are detectable after short periods of time. This underscores the dynamic nature of gray matter changes in the brain during adult life, with regional volume reductions being detectable in brain regions that are relevant to cognitive and emotional processes.