TOTAL HIP ARTHROPLASTY IN THE PUBLIC HEALTH SYSTEM OF SÃO PAULO: COMPARING TYPES OF FIXATION.

Brazil lacks registries on the prevalence of primary total hip arthroplasty (THA) fixation methods. Objective: (i) to describe the demographic profile of patients who underwent THA in the public health system of the municipality of São Paulo during the last 12 years and (ii) to compare fixation methods regarding costs, hospital stay length, and death rates. Methods: This is an ecological study conducted with data available on TabNet, a platform belonging to DATASUS. Public data (from the government health system) on THA procedures performed in São Paulo from 2008 to 2019 were extracted. Gender, age, city region, THA fixation method, number of surgeries, costs, hospital stay length, and death rates were analyzed. Results: We analyzed 7,673 THA, of which 6220 (81%) were performed via cementless/hybrid fixation and 1453 (19%), via the cemented technique. Cementless/hybrid fixation had a higher cost (US$ 495.27) than the cemented one (p < 0.001). Nevertheless, hospital stay length was 0.87 days longer for cemented fixation than the cementless/hybrid one. We found no significant difference in death rates between THA fixation methods. Conclusion: THA cementless/hybrid fixation is prevalent in the municipality of São Paulo, which had higher total costs and shorter hospitalizations than cemented fixation. We found no difference between THA fixation methods and death rates. Level of Evidence IV, Case Series.

No Brasil, não há registros da prevalência do tipo de fixação da artroplastia total de quadril (ATQ). Objetivo: (i) Descrever perfil demográfico de pacientes submetidos à ATQ no Sistema Único de Saúde de São Paulo durante os últimos doze anos; e (ii) comparar as técnicas de fixação de ATQ quanto aos custos, tempo de internação (TI) e taxa de óbito. Métodos: Estudo ecológico, com dados disponíveis na TabNet do DATASUS. Dados públicos de procedimentos de ATQ eletivos realizados em São Paulo de 2008 a 2019 foram extraídos. Foram analisados: sexo, idade, região municipal, método de fixação em ATQ, número de cirurgias, custo, tempo de internação e óbitos. Resultados: Foram analisadas 7.673 ATQs, sendo 6.220 (81%) não-cimentada/híbridas e 1.453 (19%) cimentadas. A fixação não-cimentada/híbrida teve custo maior em US$ 495,27 do que a cimentada (p < 0,001). Entretanto, TI foi 0,87 dia mais longo na fixação cimentada. Não houve diferença significativa nas taxas de óbito entre os métodos de fixação. Conclusão: A fixação não-cimentada/híbrida na ATQ é prevalente em São Paulo, e apresentou maior custo total, porém menor tempo de internação do que a fixação cimentada. Não houve diferença entre o método de fixação em ATQ e a taxa de óbito. Nível de Evidência IV, Série de Casos.

Total hip arthroplasty in the public health system of são paulo: comparing types of fixation / Artroplastia total de quadril no sistema público de são paulo: comparando os tipos de fixação

ABSTRACT Brazil lacks registries on the prevalence of primary total hip arthroplasty (THA) fixation methods. Objective: (i) to describe the demographic profile of patients who underwent THA in the public health system of the municipality of São Paulo during the last 12 years and (ii) to compare fixation methods regarding costs, hospital stay length, and death rates. Methods: This is an ecological study conducted with data available on TabNet, a platform belonging to DATASUS. Public data (from the government health system) on THA procedures performed in São Paulo from 2008 to 2019 were extracted. Gender, age, city region, THA fixation method, number of surgeries, costs, hospital stay length, and death rates were analyzed. Results: We analyzed 7,673 THA, of which 6220 (81%) were performed via cementless/hybrid fixation and 1453 (19%), via the cemented technique. Cementless/hybrid fixation had a higher cost (US$ 495.27) than the cemented one (p < 0.001). Nevertheless, hospital stay length was 0.87 days longer for cemented fixation than the cementless/hybrid one. We found no significant difference in death rates between THA fixation methods. Conclusion: THA cementless/hybrid fixation is prevalent in the municipality of São Paulo, which had higher total costs and shorter hospitalizations than cemented fixation. We found no difference between THA fixation methods and death rates. Level of Evidence IV, Case Series.

RESUMO No Brasil, não há registros da prevalência do tipo de fixação da artroplastia total de quadril (ATQ). Objetivo: (i) Descrever perfil demográfico de pacientes submetidos à ATQ no Sistema Único de Saúde de São Paulo durante os últimos doze anos; e (ii) comparar as técnicas de fixação de ATQ quanto aos custos, tempo de internação (TI) e taxa de óbito. Métodos: Estudo ecológico, com dados disponíveis na TabNet do DATASUS. Dados públicos de procedimentos de ATQ eletivos realizados em São Paulo de 2008 a 2019 foram extraídos. Foram analisados: sexo, idade, região municipal, método de fixação em ATQ, número de cirurgias, custo, tempo de internação e óbitos. Resultados: Foram analisadas 7.673 ATQs, sendo 6.220 (81%) não-cimentada/híbridas e 1.453 (19%) cimentadas. A fixação não-cimentada/híbrida teve custo maior em US$ 495,27 do que a cimentada (p < 0,001). Entretanto, TI foi 0,87 dia mais longo na fixação cimentada. Não houve diferença significativa nas taxas de óbito entre os métodos de fixação. Conclusão: A fixação não-cimentada/híbrida na ATQ é prevalente em São Paulo, e apresentou maior custo total, porém menor tempo de internação do que a fixação cimentada. Não houve diferença entre o método de fixação em ATQ e a taxa de óbito. Nível de Evidência IV, Série de Casos.

The Direct Anterior Approach for Total Hip Arthroplasty for Severe Dysplasia (Crowe III and IV) Provides Satisfactory Medium to Long-Term Outcomes.

BACKGROUND: The direct anterior approach (DAA) is increasingly used for total hip arthroplasty (THA). Although the DAA can reduce pain, recovery time, and dislocations in nondysplastic hips, few studies report its results in patients with severe dysplasia. We aimed to evaluate outcomes of primary THA through the DAA with cup placement at the true acetabulum in hips with severe dysplasia. METHODS: We retrospectively evaluated 23 consecutive patients (29 hips) who underwent THA by DAA for osteoarthritis secondary to Crowe III-IV dysplasia. Surgical procedures were performed on a traction table, and the acetabular cup was placed in the true acetabulum. Patients were assessed clinically (complications, modified Harris Hip Score, Western Ontario and McMaster Universities Osteoarthritis Index, Oxford Hip Score) and radiographically (radiolucencies, subsidence, leg length discrepancies, cup inclination, and cup coverage) at a minimum of 2 years. RESULTS: One patient (2 hips) died with original implants (at 13 and 14 years), 3 patients (3 hips) were revised due to wear-induced loosening (at 14, 16, and 18 years), and there were no dislocations or infections. The remaining 19 patients (24 hips) were assessed at 8.4 ± 4.7 years (range 2-20); 2 patients (2 hips) had complications that required reoperation without implant removal. The modified Harris Hip Score improved from 32 ± 9 to 94 ± 7, Western Ontario and McMaster Universities Osteoarthritis Index from 46 ± 18 to 90 ± 7, and Oxford Hip Score was 56 ± 4. Patients were very satisfied (90%) or satisfied (10%). Limb length discrepancy was 2.5 ± 9.0 mm. CONCLUSION: THA through the DAA with cup placement at the true acetabulum provides satisfactory mid to long-term clinical and radiographic outcomes compared to other approaches for hips with severe dysplasia. LEVEL OF EVIDENCE: Level IV, retrospective cohort study.

Comparative Study of the Osteointegration of Irradiated and Non-irradiated Bone Grafts Used in Patients with Revision Hip Arthroplasty.

Objective To evaluate and compare the osteointegration of irradiated and non-irradiated frozen bone grafts used in 21 patients undergoing revision hip arthroplasty procedures with the Exeter technique. Methods A retrospective study of 21 patients undergoing revision hip arthroplasty with the Exeter technique using bone tissues treated or not with gamma radiation between 2013 and 2014. The patients were divided into two groups according to the use of grafts treated or not with ionizing radiation (gamma rays); as such, these groups were classified as irradiated or non-irradiated. The osteointegration results determined by radiographic analysis of these grafts were compared in the postoperative period of 6 and 12 months. Results Comparing the graft osteointegration in all patients at 6 and 12 months postoperatively, we noticed a significant difference in the radiographic evaluations in this period ( p = 0.031). Out of the patients studied, 7 were from the irradiated group, and 14 belonged to the non-irradiated group. No statistically significant differences were observed ( p = 0.804) regarding osteointegration when we compared the irradiated and non-irradiated groups. Conclusion There was no significant difference in the use of irradiated or non-irradiated grafts in revision hip arthroplasty procedures with the Exeter technique.

Comparative Study of the Osteointegration of Irradiated and Non-irradiated Bone Grafts Used in Patients with Revision Hip Arthroplasty / Estudo comparativo da osteointegração de enxertos ósseos irradiados e não irradiados utilizados em pacientes com revisão de artroplastia do quadril

Abstract Objective To evaluate and compare the osteointegration of irradiated and nonirradiated frozen bone grafts used in 21 patients undergoing revision hip arthroplasty procedures with the Exeter technique. Methods A retrospective study of 21 patients undergoing revision hip arthroplasty with the Exeter technique using bone tissues treated or not with gamma radiation between 2013 and 2014. The patients were divided into two groups according to the use of grafts treated or not with ionizing radiation (gamma rays); as such, these groups were classified as irradiated or non-irradiated. The osteointegration results determined by radiographic analysis of these grafts were compared in the postoperative period of 6 and 12months. Results Comparing the graft osteointegration in all patients at 6 and 12months postoperatively, we noticed a significant difference in the radiographic evaluations in this period (p = 0.031). Out of the patients studied, 7 were from the irradiated group, and 14 belonged to the non-irradiated group. No statistically significant differences were observed (p = 0.804) regarding osteointegration when we compared the irradiated and non-irradiated groups. Conclusion There was no significant difference in the use of irradiated or nonirradiated grafts in revision hip arthroplasty procedures with the Exeter technique.

Resumo Objetivo Avaliar e comparar a osteointegração dos enxertos ósseos congelados irradiados e não irradiados utilizados em 21 pacientes submetidos a revisão de prótese do quadril pela técnica Exeter. Métodos Foi realizado estudo retrospectivo de 21 pacientes submetidos a revisão de artroplastia do quadril pela técnica Exeter comutilização de tecidos ósseos tratados ou não com radiação gama no período entre 2013 e 2014. Dividimos os pacientes em dois grupos, de acordo com o uso do enxerto tratado ou não com radiação ionizante (raios gama), que foram, portanto, classificados como: grupo irradiado e não irradiado. Os resultados da osteointegração por análise radiográfica destes enxertos foram comparados no pós-cirúrgico de 6 e 12 meses. Resultados Quando comparamos a osteointegração dos enxertos no pós-cirúrgico de 6 e 12 meses de todos os pacientes, notamos que houve diferença significativa entre as avaliações radiográficas neste período (p= 0,031). Dos pacientes estudados, 7 pertenciam ao grupo irradiado, e 14, ao grupo não irradiado. Não foram observadas diferenças estatisticamente significativas (p= 0,804) quando a osteointegração entre os grupos irradiados e não irradiados foi comparada. Conclusão Não houve diferença significativa no uso de enxerto irradiado e não irradiado nas revisões de artroplastias do quadril pela técnica Exeter.

Is the size of the acetabular bone lesion a predictive factor for failure in revisions of total hip arthroplasty using an impacted allograft?

OBJECTIVE: The aim of this study was to determine the acetabular bone lesion size (in millimeters) from which impacted bone graft failure starts to occur more frequently, through simple anteroposterior hip radiographs, and whether measurement of the defect on simple radiographs maintains the same pattern in inter and intraobserver assessments. METHODS: Thirty-eight anteroposterior pelvic-view radiographs from patients undergoing revision of an acetabular prosthesis were retrospectively analyzed and assessed. In the vertical plane, the bilacrimal line was measured in millimeters from the farthest point found on the bone edge of the acetabular osteolysis to the top edge of the cementation or of the acetabular implant in uncemented cases. The base was taken to be a line perpendicular to bilacrimal line, with the aim of eliminating any pelvic tilt effects. This measurement was named the vertical size of failure. Radiographs produced four years after the operation were analyzed to investigate any failure of the technique. RESULTS: The graft failure rate in the study group was 26.3%. The failures occurred in cases with an initial bone defect larger than 11 mm. No cases with measurements smaller than this evolved with failure of the revision. The highest incidence of graft failure occurred in cases described as advanced according to the "Paprosky" classification. CONCLUSION: Failure of acetabular revision arthroplasty using an impacted graft did not present any statistically significant correlation with the vertical extent of the lesion on simple anteroposterior radiographs, as a predictor of treatment failure.

OBJETIVO: O presente trabalho buscou, através de uma radiografia simples anteroposterior do quadril, quantificar em milímetros a partir de qual tamanho da lesão óssea acetabular ocorre com maior frequência falha do enxerto ósseo impactado e se a medição do defeito nas radiografias simples mantém o mesmo padrão na avaliação inter e intraobservador. MÉTODOS: Foram analisadas e aferidas retrospectivamente 38 radiografias de pacientes submetidos à revisão de prótese acetabular na incidência anteroposterior de bacia, mensurando em milímetros, no plano vertical a linha bilacrimal, a medida entre o ponto mais distante encontrado na borda óssea da osteolise acetabular, com a margem superior da cimentação ou implante acetabular nos casos não cimentados. Tomamos como base uma linha perpendicular a linha bilacrimal com o intuito de eliminar efeitos de inclinação pelvic. Essa medida foi denominada Tamanho Vertical da Falha. Radiografias pós-operatórias com quatro anos foram analisadas para averiguar falha da técnica. RESULTADOS: No grupo estudado observamos 26,3% de falhas do enxerto que ocorreram a partir de 11 mm de tamanho da falha óssea inicial mensurada e que abaixo desse valor nenhum caso evoluiu com falha da revisão. A maior incidência da falha do enxerto ocorreu nos casos avançados segundo a classificação de Paprosky. CONCLUSÃO: A falha na artroplastia de revisão acetabular com enxerto impactado quando relacionado à medida vertical da lesão em radiografia simples anteroposterior do quadril não apresentou significância estatística como fator preditivo de falha do tratamento.

PRP IN THE TREATMENT OF TROCHANTERIC SYNDROME: A PILOT STUDY

ABSTRACT Objective: To compare the efficacy of platelet rich plasma (PRP) against corticosteroid on the treatment of trochanteric pain syndrome . Methods: From July 2011 to November 2012, eighteen patients (20 hips) with trochanter pain syndrome were randomized in two groups and treated with platelet rich plasma or triamcinolone infiltration guided by ultrasound. Pain and function were evaluated prior to the intervention and after 10, 30 and 60 days, through the Facial Expressions Scale for Pain and the Western Ontario McMaster and Harris Hip Score questionnaires. Inter-group analysis was performed by Student t-test and intragroup analysis by ANOVA, followed by Bonferroni post hoc test. Statistical significance was set at p <0.05 . Results: There was no difference between the groups. The triamcinolone group showed pain reduction (p=0.004) and improved function (p=0.036) through the Harris Hip Score questionnaire at 10, 30 and 60 days after treatment, when compared with the pre- intervention period. The platelet rich plasma group showed no statistical improvement in any of the variables . Conclusion: Up to 60 days, PRP infiltration has no influence on pain relief and function improvement in trochanteric syndrome treatment. Level of Evidence II, Prospective Comparative Study.

Is the size of the acetabular bone lesion a predictive factor for failure in revisions of total hip arthroplasty using an impacted allograft? / O tamanho da lesão óssea acetabular é fator preditivo para a falha nas revisões de artroplastia total do quadril com enxerto impactado?

ABSTRACT OBJECTIVE: The aim of this study was to determine the acetabular bone lesion size (in millimeters) from which impacted bone graft failure starts to occur more frequently, through simple anteroposterior hip radiographs, and whether measurement of the defect on simple radiographs maintains the same pattern in inter and intraobserver assessments. METHODS: Thirty-eight anteroposterior pelvic-view radiographs from patients undergoing revision of an acetabular prosthesis were retrospectively analyzed and assessed. In the vertical plane, the bilacrimal line was measured in millimeters from the farthest point found on the bone edge of the acetabular osteolysis to the top edge of the cementation or of the acetabular implant in uncemented cases. The base was taken to be a line perpendicular to bilacrimal line, with the aim of eliminating any pelvic tilt effects. This measurement was named the vertical size of failure. Radiographs produced four years after the operation were analyzed to investigate any failure of the technique. RESULTS: The graft failure rate in the study group was 26.3%. The failures occurred in cases with an initial bone defect larger than 11 mm. No cases with measurements smaller than this evolved with failure of the revision. The highest incidence of graft failure occurred in cases described as advanced according to the "Paprosky" classification. CONCLUSION: Failure of acetabular revision arthroplasty using an impacted graft did not present any statistically significant correlation with the vertical extent of the lesion on simple anteroposterior radiographs, as a predictor of treatment failure.

RESUMO OBJETIVO: O presente trabalho buscou, através de uma radiografia simples anteroposterior do quadril, quantificar em milímetros a partir de qual tamanho da lesão óssea acetabular ocorre com maior frequência falha do enxerto ósseo impactado e se a medição do defeito nas radiografias simples mantém o mesmo padrão na avaliação inter e intraobservador. MÉTODOS: Foram analisadas e aferidas retrospectivamente 38 radiografias de pacientes submetidos à revisão de prótese acetabular na incidência anteroposterior de bacia, mensurando em milímetros, no plano vertical a linha bilacrimal, a medida entre o ponto mais distante encontrado na borda óssea da osteolise acetabular, com a margem superior da cimentação ou implante acetabular nos casos não cimentados. Tomamos como base uma linha perpendicular a linha bilacrimal com o intuito de eliminar efeitos de inclinação pelvic. Essa medida foi denominada Tamanho Vertical da Falha. Radiografias pós-operatórias com quatro anos foram analisadas para averiguar falha da técnica. RESULTADOS: No grupo estudado observamos 26,3% de falhas do enxerto que ocorreram a partir de 11 mm de tamanho da falha óssea inicial mensurada e que abaixo desse valor nenhum caso evoluiu com falha da revisão. A maior incidência da falha do enxerto ocorreu nos casos avançados segundo a classificação de Paprosky. CONCLUSÃO: A falha na artroplastia de revisão acetabular com enxerto impactado quando relacionado à medida vertical da lesão em radiografia simples anteroposterior do quadril não apresentou significância estatística como fator preditivo de falha do tratamento.

Supra-acetabular fixation and sacroiliac screws for treating unstable pelvic ring injuries: preliminary results from 20 patients.

OBJECTIVE: To analyze the treatment results from 20 patients who underwent an alternative osteosynthesis method as definitive treatment for pelvic ring fractures. METHODS: A retrospective analysis was conducted on a series of 20 patients with pelvic ring fractures (Tile type C) and a high risk of postoperative infection, who were treated at Santa Casa de Misericórdia de São Paulo between August 2004 and December 2012. The patients underwent percutaneous supra-acetabular external fixation in association with cannulated 7.0 mm iliosacral screws. RESULTS: The patients' mean age was 40 years (range 22-77 years) and the mean length of follow-up was 18.5 months (range 3-69 months). At the end of the treatment, ten patients (50%) were classified as having good results, nine patients (45%) had fair results and one patient (5%) did not have any improvement. Six patients presented complications, and paresthesia of the lateral femoral cutaneous nerve was the most frequent of these (two patients). CONCLUSION: Supra-acetabular external fixation in association with iliosacral percutaneous osteosynthesis is a good definitive treatment method for patients with a high risk of postoperative infection.

OBJETIVO: Avaliar os resultados do tratamento de 20 pacientes que usaram como tratamento definitivo um método de osteossíntese opcional para fraturas do anel pélvico. MÉTODOS: Foi feita uma análise retrospectiva da série de 20 casos de pacientes com fratura do anel pélvico tipo C de Tile, portadores de alto risco de infecção pós-operatória, tratados na Santa Casa de Misericórdia de São Paulo entre agosto de 2004 e dezembro de 2012, submetidos a fixação externa supra-acetabular percutânea associada com parafusos canulados iliossacrais de 70 mm. RESULTADOS: A média de idade dos pacientes foi de 40 anos (mínimo de 22; máximo de 77) e o tempo médio de seguimento foi de 18,5 meses (mínimo de três; máximo de 69). Após o término do tratamento dez pacientes (50%) foram classificados com bons resultados, nove (45%) tiveram desfecho regular e um (5%) não apresentou melhoria alguma. Seis apresentaram complicações. A parestesia do nervo cutâneo femoral lateral foi a mais frequente (dois pacientes). CONCLUSÃO: A fixação externa supra-acetabular associada a osteossíntese percutânea iliossacral é um bom método de tratamento definitivo para os pacientes com alto risco de infecção pós-operatória.

Effects of ionizing radiation on proteins in lyophilized or frozen demineralized human bone.

OBJECTIVE: The aim was to study the effects of application of ionizing radiation (gamma and electrons) as sterilizing agents at doses of 15 kGy, 25 kGy and 50 kGy, on lyophilized or frozen demineralized bone tissue for use in transplants. METHODS: Five human femoral diaphyses from different donors of musculoskeletal tissue were demineralized and preserved as lyophilized or frozen at -80 °C. The samples were divided into two groups: non-irradiated (control) and irradiated by means of gamma rays or an electron beam. The bone proteins were extracted and used to determine the concentrations of total protein and BMP 2 and 7. RESULTS: Decreases in total protein and BMP 2 and 7 concentrations were observed. The decreases in total protein concentrations, in comparison with the respective control groups, were significant in the lyophilized and frozen samples that were irradiated at a dose of 50 kGy of gamma radiation and electron beam, with reductions of more than 30%. Significant decreases in the levels of BMP 2 and 7 were also observed at higher doses and especially through use of the electron beam. CONCLUSION: The reductions in the concentrations of total proteins and osteoinductive proteins (BMP 2 and 7) were related to the radiation dose, i.e. they increased with higher doses of ionizing radiation type and the type of bone preservation. The largest reductions in concentrations were observed in the bones irradiated by means of an electron beam and at a dose of 50 kGy. However, this type of radiation and this high dose are not usual practices for sterilization of bone tissue.

OBJETIVO: Estudar os efeitos da aplicação das radiações ionizantes (gama e elétrons) como agentes esterilizantes, nas doses de 15 kGy, 25 kGy e 50 kGy, nos tecidos ósseos desmineralizados congelados e liofilizados para uso em transplantes. MÉTODOS: Cinco diáfises femorais humanas de doadores distintos de tecidos musculoesqueléticos foram desmineralizadas e preservadas como liofilizadas ou congeladas a −80 °C. As amostras foram divididas em grupos não irradiados (controle) e irradiados por raios gama ou feixe de elétrons. As proteínas ósseas foram extraídas e dosadas as concentrações de proteínas totais, BMP 2 e 7. RESULTADOS: Foi observada diminuição das concentrações de proteínas totais e BMP 2 e 7. A diminuição das concentrações de proteínas totais, quando comparada com o respectivo controle, foi significativa nos grupos de amostras liofilizadas e congeladas e irradiadas na dose de 50 kGy por radiação gama e feixe de elétrons com redução superiores a 30%. A diminuição significativa nas concentrações das BMP 2 e 7 também foi observada nas maiores doses e principalmente por feixe de elétrons. CONCLUSÃO: As reduções nas concentrações das proteínas totais e em proteínas osteoindutoras (BMP 2 e 7) foram relacionadas à dose de radiação, ou seja, aumentam com maiores doses, tipo de radiação ionizante e ao tipo de preservação dos ossos. As maiores reduções das concentrações foram observadas nos ossos irradiados por feixe de elétrons e na dose de 50 kGy. Porém esse tipo de radiação e essa alta dose não são práticas usuais para a esterilização dos tecidos ósseos.

Effects of ionizing radiation on proteins in lyophilized or frozen demineralized human bone / Efeitos da radiação ionizante nas proteínas presentes em ossos humanos desmineralizados, liofilizados ou congelados

OBJECTIVE: The aim was to study the effects of application of ionizing radiation (gamma and electrons) as sterilizing agents at doses of 15 kGy, 25 kGy and 50 kGy, on lyophilized or frozen demineralized bone tissue for use in transplants. METHODS: Five human femoral diaphyses from different donors of musculoskeletal tissue were demineralized and preserved as lyophilized or frozen at -80 °C. The samples were divided into two groups: non-irradiated (control) and irradiated by means of gamma rays or an electron beam. The bone proteins were extracted and used to determine the concentrations of total protein and BMP 2 and 7. RESULTS: Decreases in total protein and BMP 2 and 7 concentrations were observed. The decreases in total protein concentrations, in comparison with the respective control groups, were significant in the lyophilized and frozen samples that were irradiated at a dose of 50 kGy of gamma radiation and electron beam, with reductions of more than 30%. Significant decreases in the levels of BMP 2 and 7 were also observed at higher doses and especially through use of the electron beam. CONCLUSION: The reductions in the concentrations of total proteins and osteoinductive proteins (BMP 2 and 7) were related to the radiation dose, i.e. they increased with higher doses of ionizing radiation type and the type of bone preservation. The largest reductions in concentrations were observed in the bones irradiated by means of an electron beam and at a dose of 50 kGy. However, this type of radiation and this high dose are not usual practices for sterilization of bone tissue.

OBJETIVO: Estudar os efeitos da aplicação das radiações ionizantes (gama e elétrons) como agentes esterilizantes, nas doses de 15 kGy, 25 kGy e 50 kGy, nos tecidos ósseos desmineralizados congelados e liofilizados para uso em transplantes. MÉTODOS: Cinco diáfises femorais humanas de doadores distintos de tecidos musculoesqueléticos foram desmineralizadas e preservadas como liofilizadas ou congeladas a -80 °C. As amostras foram divididas em grupos não irradiados (controle) e irradiados por raios gama ou feixe de elétrons. As proteínas ósseas foram extraídas e dosadas as concentrações de proteínas totais, BMP 2 e 7. RESULTADOS: Foi observada diminuição das concentrações de proteínas totais e BMP 2 e 7. A diminuição das concentrações de proteínas totais, quando comparada com o respectivo controle, foi significativa nos grupos de amostras liofilizadas e congeladas e irradiadas na dose de 50 kGy por radiação gama e feixe de elétrons com redução superiores a 30%. A diminuição significativa nas concentrações das BMP 2 e 7 também foi observada nas maiores doses e principalmente por feixe de elétrons. CONCLUSÃO: As reduções nas concentrações das proteínas totais e em proteínas osteoindutoras (BMP 2 e 7) foram relacionadas à dose de radiação, ou seja, aumentam com maiores doses, tipo de radiação ionizante e ao tipo de preservação dos ossos. As maiores reduções das concentrações foram observadas nos ossos irradiados por feixe de elétrons e na dose de 50 kGy. Porém esse tipo de radiação e essa alta dose não são práticas usuais para a esterilização dos tecidos ósseos.

Supra-acetabular fixation and sacroiliac screws for treating unstable pelvic ring injuries: preliminary results from 20 patients / Tratamento das lesões instáveis do anel pélvico com fixador supra-acetabular e parafusos sacroilíacos: resultados preliminares em 20 pacientes

OBJECTIVE: To analyze the treatment results from 20 patients who underwent an alternative osteosynthesis method as definitive treatment for pelvic ring fractures. METHODS: A retrospective analysis was conducted on a series of 20 patients with pelvic ring fractures (Tile type C) and a high risk of postoperative infection, who were treated at Santa Casa de Misericórdia de São Paulo between August 2004 and December 2012. The patients underwent percutaneous supra-acetabular external fixation in association with cannulated 7.0 mm iliosacral screws. RESULTS: The patients' mean age was 40 years (range 22-77 years) and the mean length of follow-up was 18.5 months (range 3-69 months). At the end of the treatment, ten patients (50%) were classified as having good results, nine patients (45%) had fair results and one patient (5%) did not have any improvement. Six patients presented complications, and paresthesia of the lateral femoral cutaneous nerve was the most frequent of these (two patients). CONCLUSION: Supra-acetabular external fixation in association with iliosacral percutaneous osteosynthesis is a good definitive treatment method for patients with a high risk of postoperative infection.

OBJETIVO: Avaliar os resultados do tratamento de 20 pacientes que usaram como tratamento definitivo um método de osteossíntese opcional para fraturas do anel pélvico. MÉTODOS: Foi feita uma análise retrospectiva da série de 20 casos de pacientes com fratura do anel pélvico tipo C de Tile, portadores de alto risco de infecção pós-operatória, tratados na Santa Casa de Misericórdia de São Paulo entre agosto de 2004 e dezembro de 2012, submetidos a fixação externa supra-acetabular percutânea associada com parafusos canulados iliossacrais de 70 mm. RESULTADOS: A média de idade dos pacientes foi de 40 anos (mínimo de 22; máximo de 77) e o tempo médio de seguimento foi de 18,5 meses (mínimo de três; máximo de 69). Após o término do tratamento dez pacientes (50%) foram classificados com bons resultados, nove (45%) tiveram desfecho regular e um (5%) não apresentou melhoria alguma. Seis apresentaram complicações. A parestesia do nervo cutâneo femoral lateral foi a mais frequente (dois pacientes). CONCLUSÃO: A fixação externa supra-acetabular associada a osteossíntese percutânea iliossacral é um bom método de tratamento definitivo para os pacientes com alto risco de infecção pós-operatória.

PRP IN THE TREATMENT OF TROCHANTERIC SYNDROME: A PILOT STUDY.

OBJECTIVE: To compare the efficacy of platelet rich plasma (PRP) against corticosteroid on the treatment of trochanteric pain syndrome . METHODS: From July 2011 to November 2012, eighteen patients (20 hips) with trochanter pain syndrome were randomized in two groups and treated with platelet rich plasma or triamcinolone infiltration guided by ultrasound. Pain and function were evaluated prior to the intervention and after 10, 30 and 60 days, through the Facial Expressions Scale for Pain and the Western Ontario McMaster and Harris Hip Score questionnaires. Inter-group analysis was performed by Student t-test and intragroup analysis by ANOVA, followed by Bonferroni post hoc test. Statistical significance was set at p <0.05 . RESULTS: There was no difference between the groups. The triamcinolone group showed pain reduction (p=0.004) and improved function (p=0.036) through the Harris Hip Score questionnaire at 10, 30 and 60 days after treatment, when compared with the pre- intervention period. The platelet rich plasma group showed no statistical improvement in any of the variables . CONCLUSION: Up to 60 days, PRP infiltration has no influence on pain relief and function improvement in trochanteric syndrome treatment. Level of Evidence II, Prospective Comparative Study.

Epidemiology of fractures of the proximal third of the femur in elderly patients.

OBJECTIVE: This was an epidemiological study on fractures of the proximal third of the femur in elderly patients who were treated at a teaching hospital in the central region of São Paulo. METHODS: The subjects were patients over the age of 60 years who were attended over a 1-year period. A questionnaire seeking basic sociodemographic data and information on comorbidities presented and medications used was drawn up. The circumstances of the fractures and their characteristics, the treatment instituted and the intra-hospital mortality rate were evaluated. RESULTS: The 113 patients included in the study presented a mean age of 79 years. The ratio between the sexes was three women to each man. Only 30.4% of the patients reported having osteoporosis and only 0.9% had had treatment for the disease. Low-energy trauma was the cause of 92.9% of the fractures. Femoral neck fractures accounted for 42.5% of the fractures and trochanteric fractures, 57.5%. Five patients did not undergo operations; 39 underwent joint replacement; and 69 underwent osteosynthesis. The mean length of hospital stay was 13.5 days and the mean length of waiting time until surgery was 7 days. The intra-hospital mortality rate was 7.1%. CONCLUSION: The patients attended at this institution presented an epidemiological profile similar to what is found in the Brazilian literature. Chronic kidney failure is a significant factor with regard to intra-hospital mortality. Preventive measures such as early diagnosis and treatment of osteoporosis and regular physical activity practices were not implemented.

OBJETIVO: Estudo epidemiológico das fraturas do terço proximal do fêmur em pacientes idosos, tratados em hospital-escola na região central de São Paulo. MÉTODOS: Pacientes a partir 60 anos atendidos no período de um ano. Questionário foi elaborado com informações sociodemográficas básicas, comorbidades apresentadas e medicações em uso. Foram avaliadas circunstâncias da fratura e suas características, tratamento instituído e taxa de mortalidade intra-hospitalar. RESULTADOS: Os 113 pacientes incluídos no estudo apresentavam 79 anos em média. A proporção entre os sexos foi de três mulheres para cada homem. Somente 30.4% dos pacientes relataram osteoporose e somente 0.9% tratavam a doença. Trauma de baixa energia foi a causa de 92,9% das fraturas. Fraturas do colo do fêmur representaram 42,5% das fraturas e trocantéricas 57,5%. Cinco pacientes não foram operados, 39 foram submetidos a substituição articular e 69 foram submetidos a osteossíntese. O tempo médio de internação foi de 13,5 dias e de espera até a cirurgia sete dias. A taxa de mortalidade intra-hospitalar foi de 7,1%. CONCLUSÃO: Pacientes atendidos na instituição apresentam perfil epidemiológico semelhante àqueles encontrados em literatura nacional. Insuficiência renal crônica é um fator significativo para mortalidade intra-hospitalar. Medidas preventivas como diagnóstico precoce e tratamento da osteoporose e prática regular de atividades físicas não são adotadas.

Prevalence and risk factors for intra-operative periprosthetic fractures in one thousand eight hundred and seventy two patients undergoing total hip arthroplasty: a cross-sectional study.

PURPOSE: The purpose of this study was to identify the frequency and type of intra-operative periprosthetic fractures and to describe risk factors in a single tertiary, public hospital, so that these events could be prevented, even among less experienced surgeons. METHODS: This is a cross-sectional study, based on medical records and imaging exams from the archives of a public, tertiary hospital, from April 1998 to October 2013. All consecutive patients submitted to total hip arthroplasty (THA) in the study period were evaluated, excluding unipolar or bipolar arthroplasty, surgery for the osteosynthesis of periprosthetic fractures, surgical procedure to clean infection site without component substitution and not arthroplastic surgery. Data were analyzed with chi-squared test and multivariate Cox regression. RESULTS: In the study period, 1,872 THA (1,728 patients) were performed and analyzed, with 144 bilateral cases. In 173 cases, patients had undergone surgical procedures other than THA previously, and in only 260 the surgery consisted of revision THA. There were only two cases of resection THA. Among all patients 101 intra-operative periprosthetic fractures occurred. The univariate analysis revealed a significantly higher risk of intra-operative fractures in female patients, aged more than 65 years, with indication of primary THA and the presence of a previous hip surgery. It indicated also that revision surgeries were associated with a 2.8-fold higher risk of intra-operative fracture, 2.18-fold risk in a previously operated hip and 3.9-fold in cases of resection THA or revision surgery in two stages. CONCLUSIONS: Intraoperative periprosthetic fracture is a rare event, and it is associated with revision type surgery and THA in a previously operated hip.

Epidemiologia das fraturas do terço proximal do fêmur em pacientes idosos / Epidemiology of fractures of the proximal third of the femur in elderly patients

Estudo epidemiológico das fraturas do terço proximal do fêmur em pacientes idosos, tratados em hospital-escola na região central de São Paulo. MÉTODOS: Pacientes a partir 60 anos atendidos no período de um ano. Questionário foi elaborado com informações sociodemográficas básicas, comorbidades apresentadas e medicações em uso. Foram avaliadas circunstâncias da fratura e suas características, tratamento instituído e taxa de mortalidade intra-hospitalar. RESULTADOS: Os 113 pacientes incluídos no estudo apresentavam 79 anos em média. A proporção entre os sexos foi de três mulheres para cada homem. Somente 30,4% dos pacientes relataram osteoporose e somente 0,9% tratavam a doença. Trauma de baixa energia foi a causa de 92,9% das fraturas. Fraturas do colo do fêmur representaram 42,5% das fraturas e trocantéricas 57,5%. Cinco pacientes não foram operados, 39 foram submetidos a substituição articular e 69 foram submetidos a osteossíntese. O tempo médio de internação foi de 13,5 dias e de espera até a cirurgia sete dias. A taxa de mortalidade intra-hospitalar foi de 7,1%. CONCLUSÃO: Pacientes atendidos na instituição apresentam perfil epidemiológico semelhante àqueles encontrados em literatura nacional. Insuficiência renal crônica é um fator significativo para mortalidade intra-hospitalar. Medidas preventivas como diagnóstico precoce e tratamento da osteoporose e prática regular de atividades físicas não são adotadas.

This was an epidemiological study on fractures of the proximal third of the femur in elderly patients who were treated at a teaching hospital in the central region of São Paulo. METHODS: The subjects were patients over the age of 60 years who were attended over a 1-year period. A questionnaire seeking basic sociodemographic data and information on comorbidities presented and medications used was drawn up. The circumstances of the fractures and their characteristics, the treatment instituted and the intra-hospital mortality rate were evaluated. RESULTS: The 113 patients included in the study presented a mean age of 79 years. The ratio between the sexes was three women to each man. Only 30.4% of the patients reported having osteoporosis and only 0.9% had had treatment for the disease. Low-energy trauma was the cause of 92.9% of the fractures. Femoral neck fractures accounted for 42.5% of the fractures and trochanteric fractures, 57.5%. Five patients did not undergo operations; 39 underwent joint replacement; and 69 underwent osteosynthesis. The mean length of hospital stay was 13.5 days and the mean length of waiting time until surgery was 7 days. The intra-hospital mortality rate was 7.1%. CONCLUSION: The patients attended at this institution presented an epidemiological profile similar to what is found in the Brazilian literature. Chronic kidney failure is a significant factor with regard to intra-hospital mortality. Preventive measures such as early diagnosis and treatment of osteoporosis and regular physical activity practices were not implemented.

Current possibilities for hip arthroplasty / Possibilidades atuais da artroscopia do quadril

Hip arthroscopy has been popularized over the last decade and, with technical advances regarding imaging diagnostics, understanding of the physiopathology or surgical techniques, several applications have been described. Both arthroscopy for intra-articular conditions and endoscopy for extra-articular procedures can be used in diagnosing or treating different conditions. This updated article has the objective of presenting the various current possibilities for hip arthroscopy...

A artroscopia de quadril tem sido popularizada na última década e com o avanço técnico, seja no diagnóstico por imagem, no entendimento da fisiopatologia ou na técnica cirúrgica, diversas aplicações foram descritas. Tanto a artroscopia, para afecções intra-articulares, como a endoscopia, para procedimentos extra-articulares, podem ser usadas no diagnóstico ou no tratamento de diferentes afecções. Este artigo de atualização tem como objetivo apresentar diversas possibilidades atuais da artroscopia de quadril...

There have been changes in the incidence and epidemiology of pelvic ring fractures in recent decades? / Houve mudanças na incidência e na epidemiologia das fraturas do anel pélvico nas últimas décadas?

The pelvic ring fractures comprise 2 -8% of all skeletal injuries. As the incidence rises to 25% in polytrauma and represents a negative prognostic factor with regard to morbidity and mortality of patients, we sought with this work to establish the profile of these, compared to an alteration in the profile of patients with pelvic ring fractures in recent decades. To this end, we evaluated the epidemiological profile, mechanism of injury and types of fractures. By reviewing the literature indexed in the databases related to the theme, 20 papers were selected that contained the requirements for the study. For the period between January 1987 and December 1999 (first decade), and another period in January 2000 and December 2010 (second decade), data were analyzed by Mann -Whitney test. The ratings Tile, Young and Burgess AO were adequate to permit their categorization. The research in each decade was homogeneous. At first the lesions were more prevalent in men with 62.5% with a tendency to reverse this pattern given the increase of women in the second decade (p = 0.286). The average age in the first decade was 39.3 years, an increase in the second (p = 0.068). The most prevalent mechanisms of trauma were related to traffic in both periods as well as fractures classified as type A (p = 0.203 and p = 0.457, respectively), having mortality rates decreased (p = 0.396). We conclude that there was a tendency to increase in the average age of patients (p = 0.068); however the increasing involvement of women (p = 0.286) and decreased mortality (p = 0.396) were not significant.

As fraturas do anel pélvico compõem de 2% a 8% de todas as lesões do esqueleto, incidência que sobe para 25% nos politraumatizados e representa fator prognóstico negativo no que diz respeito à morbidade e à mortalidade. Buscou-se com este trabalho estabelecer se houve mudança do perfil desses pacientes nas últimas décadas e por que ela ocorreu. Para tanto, avaliaram-se epidemiologia, mecanismo de trauma e tipos de fratura, por revisão bibliográfica nas bases de dados indexadas relacionadas ao tema, selecionados 20 trabalhos que continham os requisitos para o estudo. O período entre janeiro de 1987 e dezembro de 1999 (primeira década) e outro de janeiro de 2000 a dezembro de 2010 (segunda década) foram analisados e comparados estatisticamente pelo Teste de Mann-Whitney. As classificações de Tile, Young Burgess e AO foram adequadas para permitir sua categorização. As pesquisas em cada uma das décadas foram homogêneas. Na primeira, as lesões foram mais prevalentes em homens, com 62,5%, com tendência a inversão desse padrão, dado o aumento de mulheres acometidas na segunda década (p = 0,286). A média de idade na primeira década era de 39,3 anos e revelou um aumento na segunda (p = 0,068). Os mecanismos de trauma mais prevalentes foram aqueles relacionados ao tráfego nos períodos, assim como as fraturas classificadas como do tipo A (p = 0,203ep= 0,457, respectivamente). Os índices de mortalidade diminuíram (p = 0,396). Conclui-se que houve tendência ao aumento na média de idade dos pacientes (p = 0,068). Já o crescente acometimento das mulheres (p = 0,286) e a diminuição da mortalidade (p = 0,396) não foram significantes. .

There have been changes in the incidence and epidemiology of pelvic ring fractures in recent decades?

The pelvic ring fractures comprise 2-8% of all skeletal injuries. As the incidence rises to 25% in polytrauma and represents a negative prognostic factor with regard to morbidity and mortality of patients, we sought with this work to establish the profile of these, compared to an alteration in the profile of patients with pelvic ring fractures in recent decades. To this end, we evaluated the epidemiological profile, mechanism of injury and types of fractures. By reviewing the literature indexed in the databases related to the theme, 20 papers were selected that contained the requirements for the study. For the period between January 1987 and December 1999 (first decade), and another period in January 2000 and December 2010 (second decade), data were analyzed by Mann-Whitney test. The ratings Tile, Young and Burgess AO were adequate to permit their categorization. The research in each decade was homogeneous. At first the lesions were more prevalent in men with 62.5% with a tendency to reverse this pattern given the increase of women in the second decade (p = 0.286). The average age in the first decade was 39.3 years, an increase in the second (p = 0.068). The most prevalent mechanisms of trauma were related to traffic in both periods as well as fractures classified as type A (p = 0.203 and p = 0.457, respectively), having mortality rates decreased (p = 0.396). We conclude that there was a tendency to increase in the average age of patients (p = 0.068); however the increasing involvement of women (p = 0.286) and decreased mortality (p = 0.396) were not significant.

As fraturas do anel pélvico compõem de 2% a 8% de todas as lesões do esqueleto, incidência que sobe para 25% nos politraumatizados e representa fator prognóstico negativo no que diz respeito à morbidade e à mortalidade. Buscou-se com este trabalho estabelecer se houve mudança do perfil desses pacientes nas últimas décadas e por que ela ocorreu. Para tanto, avaliaram-se epidemiologia, mecanismo de trauma e tipos de fratura, por revisão bibliográfica nas bases de dados indexadas relacionadas ao tema, selecionados 20 trabalhos que continham os requisitos para o estudo. O período entre janeiro de 1987 e dezembro de 1999 (primeira década) e outro de janeiro de 2000 a dezembro de 2010 (segunda década) foram analisados e comparados estatisticamente pelo Teste de Mann­Whitney. As classificações de Tile, Young Burgess e AO foram adequadas para permitir sua categorização. As pesquisas em cada uma das décadas foram homogêneas. Na primeira, as lesões foram mais prevalentes em homens, com 62,5%, com tendência a inversão desse padrão, dado o aumento de mulheres acometidas na segunda década (p = 0,286). A média de idade na primeira década era de 39,3 anos e revelou um aumento na segunda (p = 0,068). Os mecanismos de trauma mais prevalentes foram aqueles relacionados ao tráfego nos períodos, assim como as fraturas classificadas como do tipo A (p = 0,203 e p = 0,457, respectivamente). Os índices de mortalidade diminuíram (p = 0,396). Conclui-se que houve tendência ao aumento na média de idade dos pacientes (p = 0,068). Já o crescente acometimento das mulheres (p = 0,286) e a diminuição da mortalidade (p = 0,396) não foram significantes.