Chronic liver disease associated to copper accumulation in an american Pitbull Terrier / Hepatopatia crônica associada ao acúmulo de cobre em um cão da raça American Pitbull Terrier

Background: The liver plays a variety of essential biochemical functions such as the metabolism of carbohydrates, proteins, lipids and vitamins, the maintenance of blood glucose and bile acids synthesis. Hepatic insuffi ciency occurs when 70 to 80% of the functional liver mass is committed the liver is unable to metabolize substances on the circulation. In some cases, chronic liver disease may be associated with copper accumulation, which may occur by increased dietary intake, faults in hepatic copper metabolism or liver diseases that cause colestase. The purpose of this paper is to report a case of chronic liver disease associated with copper accumulation in a 8-month-old American Pit Bull Terrier.Case: An American Pitbull Terrier was referred to the Veterinary Teaching Hospital of the Federal University of Rio Grande do Sul with a history of abdominal distension, decreased appetite, vomiting, diarrhea, weight loss and exhaustion. On physical examination the animal presented ascites and dehydration and laboratory tests were suggestive of active liver disease. Supportive care was provided. The patient was prescribed ranitidine (2 mg/kg) VO BID for 7 days, metoclopramide (0.3 mg/kg) VO BID also for 7 days and furosemide (1 mg/kg) PO BID until further instructions while awaiting for test results. The next appointment was scheduled for ten days later but the owner came back for co

Background: The liver plays a variety of essential biochemical functions such as the metabolism of carbohydrates, proteins, lipids and vitamins, the maintenance of blood glucose and bile acids synthesis. Hepatic insuffi ciency occurs when 70 to 80% of the functional liver mass is committed the liver is unable to metabolize substances on the circulation. In some cases, chronic liver disease may be associated with copper accumulation, which may occur by increased dietary intake, faults in hepatic copper metabolism or liver diseases that cause colestase. The purpose of this paper is to report a case of chronic liver disease associated with copper accumulation in a 8-month-old American Pit Bull Terrier.Case: An American Pitbull Terrier was referred to the Veterinary Teaching Hospital of the Federal University of Rio Grande do Sul with a history of abdominal distension, decreased appetite, vomiting, diarrhea, weight loss and exhaustion. On physical examination the animal presented ascites and dehydration and laboratory tests were suggestive of active liver disease. Supportive care was provided. The patient was prescribed ranitidine (2 mg/kg) VO BID for 7 days, metoclopramide (0.3 mg/kg) VO BID also for 7 days and furosemide (1 mg/kg) PO BID until further instructions while awaiting for test results. The next appointment was scheduled for ten days later but the owner came back for co

Chronic liver disease associated to copper accumulation in an american Pitbull Terrier / Hepatopatia crônica associada ao acúmulo de cobre em um cão da raça American Pitbull Terrier

Background: The liver plays a variety of essential biochemical functions such as the metabolism of carbohydrates, proteins, lipids and vitamins, the maintenance of blood glucose and bile acids synthesis. Hepatic insuffi ciency occurs when 70 to 80% of the functional liver mass is committed the liver is unable to metabolize substances on the circulation. In some cases, chronic liver disease may be associated with copper accumulation, which may occur by increased dietary intake, faults in hepatic copper metabolism or liver diseases that cause colestase. The purpose of this paper is to report a case of chronic liver disease associated with copper accumulation in a 8-month-old American Pit Bull Terrier.Case: An American Pitbull Terrier was referred to the Veterinary Teaching Hospital of the Federal University of Rio Grande do Sul with a history of abdominal distension, decreased appetite, vomiting, diarrhea, weight loss and exhaustion. On physical examination the animal presented ascites and dehydration and laboratory tests were suggestive of active liver disease. Supportive care was provided. The patient was prescribed ranitidine (2 mg/kg) VO BID for 7 days, metoclopramide (0.3 mg/kg) VO BID also for 7 days and furosemide (1 mg/kg) PO BID until further instructions while awaiting for test results. The next appointment was scheduled for ten days later but the owner came back for co

Background: The liver plays a variety of essential biochemical functions such as the metabolism of carbohydrates, proteins, lipids and vitamins, the maintenance of blood glucose and bile acids synthesis. Hepatic insuffi ciency occurs when 70 to 80% of the functional liver mass is committed the liver is unable to metabolize substances on the circulation. In some cases, chronic liver disease may be associated with copper accumulation, which may occur by increased dietary intake, faults in hepatic copper metabolism or liver diseases that cause colestase. The purpose of this paper is to report a case of chronic liver disease associated with copper accumulation in a 8-month-old American Pit Bull Terrier.Case: An American Pitbull Terrier was referred to the Veterinary Teaching Hospital of the Federal University of Rio Grande do Sul with a history of abdominal distension, decreased appetite, vomiting, diarrhea, weight loss and exhaustion. On physical examination the animal presented ascites and dehydration and laboratory tests were suggestive of active liver disease. Supportive care was provided. The patient was prescribed ranitidine (2 mg/kg) VO BID for 7 days, metoclopramide (0.3 mg/kg) VO BID also for 7 days and furosemide (1 mg/kg) PO BID until further instructions while awaiting for test results. The next appointment was scheduled for ten days later but the owner came back for co

Uso dos marcadores imunocitoquímicos MOC-31 e D2-40 como auxílio diagnóstico em efusões neoplásticas caninas

Introdução: A análise citológica dessas efusões é importante para o diagnóstico, principalmente de malignidades, embora apresente baixa sensibilidade. A diferenciação entre os diversos tipos neoplásicos na citologia de efusões torna necessária a investigação de um painel imunocitoquímico válido, incluindo novos anticorpos como MOC-31 e D2-40. Estes anticorpos auxiliam na diferenciação entre mesoteliomas e carcinomas, enquanto que outros anticorpos, de imunorreatividade conhecida para a espécie canina, como a vimentina, a citoqueratina AE1/AE3, o CD3 e o CD79cy, auxiliam na detecção de sarcomas e linfomas. O objetivo deste estudo foi padronizar e incluir os marcadores imunocitoquímicos MOC-31 e D2-40 em um painel mínimo, que permita defi nir o tipo neoplásico em efusões caninas.Materiais, Métodos e Resultados: Quatorze amostras de efusões neoplásicas caninas foram obtidas do atendimento clínico do Hospital de Clínicas Veterinárias da UFRGS. Após a análise, os sedimentos das amostras foram fi xados em solução de formalina tamponada 10%, formando um pellet celular. Estes foram incluídos em parafi na e processados pelas técnicas histológicas de rotina. Aos cortes citológicos de cada amostra foram aplicadas as técnicas de imunocitoquímica (ICQ) pelo método estreptavidina-biotina ligada à peroxidase, para os anticorpos primários anti-citoqueratina, anti-vimentina, D2-40 e MOC-31. Pa

Uso dos marcadores tumoriais CEA, CYFRA21-1 e CA72-4 como ferramentas auxiliares no diagnóstico de efusões neoplásticas em cães

Introdução: Marcadores tumorais são substâncias produzidas por células neoplásicas ou pelo hospedeiro em resposta ao tumor, que podem ser detectadas em fl uidos corporais e utilizadas no manejo de pacientes com câncer. O fragmento de citoqueratina 19 (CYFRA 21-1) apresenta boa sensibilidade para carcinoma pulmonar de células escamosas e mesoteliomas, apesar de estar presente também no epitélio normal. O antígeno associado a câncer 72-4 (CA 72-4) é sensível para vários tipos de adenocarcinomas, principalmente na região gástrica. O antígeno carcinoembrionário (CEA) apresenta níveis elevados especialmente em neoplasmas de origem epitelial. O objetivo deste estudo foi investigar o desempenho dos marcadores tumorais bioquímicos CYFRA 21-1, CA 72-4 e CEA na diferenciação entre efusões neoplásicas e não neoplásicas de cães.Materiais, Métodos e Resultados: Trinta e duas amostras de efusões torácicas e abdominais caninas provenientes do atendimento clínico do Hospital de Clínicas Veterinárias da UFRGS foram escolhidas para as análises dos marcadores tumorais, classifi cando-se em grupo neoplásico e grupo não neoplásico. As amostras neoplásicas corresponderam a um mesotelioma, seis carcinomas, seis sarcomas, uma histiocitose maligna e dois linfomas. Os marcadores tumorais foram mensurados pelo método imunoenzimático ELISA sanduíche (Enzyme Linked Immunosorbent Assay), de acordo com instr

Hemangioma and myelolipoma in the adrenal gland of a dog / Hemangioma e mielolipoma em glândula adrenal de cão

Background: Endocrine tumors are considered rare in veterinary medicine. Studies suggest that only one or two per cent of these are primary neoplasms of the adrenal glands. Concerning the histological classifi cation of these masses, the most frequently occurring malignant neoplasms in dogs are adenocarcinomas and pheochromocytomas and, among the benign tumors, adenomas are the most common. Although much rarer, hemangiomas, myelolipomas, among others, may also occur. Dogs with this kind of neoplasm could be asyntomatic or show gastrointestinal signs, pain and urinary tract infection. Adrenalectomy is the treatment of choice and could be curative in most cases. This paper reports a case of two concurrent benign, rare adrenal neoplasms in a dog, emphasizing the clinical signs, diagnosis and treatmentCase: An eight-year-old, male castrated Chow-chow, weighting twenty one kilograms, was admitted at the Veterinary Teaching Hospital of the Federal University of Rio Grande do Sul (UFRGS) with a history of intermittent vomiting and diarrhea since it was a puppy. Because of the chronicity and nonspecifi c signs, additional tests were requested. Abdominal ultrasonography showed a round mass, measuring approximately 3.7 cm x 3.2 cm, suggesting a neoplasm. Blood pressure was measured and the mean value was 152 mmHg. Laboratory tests included a complete blood count, albumin (31.62 g/L), ala

Background: Endocrine tumors are considered rare in veterinary medicine. Studies suggest that only one or two per cent of these are primary neoplasms of the adrenal glands. Concerning the histological classifi cation of these masses, the most frequently occurring malignant neoplasms in dogs are adenocarcinomas and pheochromocytomas and, among the benign tumors, adenomas are the most common. Although much rarer, hemangiomas, myelolipomas, among others, may also occur. Dogs with this kind of neoplasm could be asyntomatic or show gastrointestinal signs, pain and urinary tract infection. Adrenalectomy is the treatment of choice and could be curative in most cases. This paper reports a case of two concurrent benign, rare adrenal neoplasms in a dog, emphasizing the clinical signs, diagnosis and treatment.Case: An eight-year-old, male castrated Chow-chow, weighting twenty one kilograms, was admitted at the Veterinary Teaching Hospital of the Federal University of Rio Grande do Sul (UFRGS) with a history of intermittent vomiting and diarrhea since it was a puppy. Because of the chronicity and nonspecifi c signs, additional tests were requested. Abdominal ultrasonography showed a round mass, measuring approximately 3.7 cm x 3.2 cm, suggesting a neoplasm. Blood pressure was measured and the mean value was 152 mmHg. Laboratory tests included a complete blood count, albumin (31.62 g/L), al

Hemangioma and myelolipoma in the adrenal gland of a dog / Hemangioma e mielolipoma em glândula adrenal de cão

Background: Endocrine tumors are considered rare in veterinary medicine. Studies suggest that only one or two per cent of these are primary neoplasms of the adrenal glands. Concerning the histological classifi cation of these masses, the most frequently occurring malignant neoplasms in dogs are adenocarcinomas and pheochromocytomas and, among the benign tumors, adenomas are the most common. Although much rarer, hemangiomas, myelolipomas, among others, may also occur. Dogs with this kind of neoplasm could be asyntomatic or show gastrointestinal signs, pain and urinary tract infection. Adrenalectomy is the treatment of choice and could be curative in most cases. This paper reports a case of two concurrent benign, rare adrenal neoplasms in a dog, emphasizing the clinical signs, diagnosis and treatmentCase: An eight-year-old, male castrated Chow-chow, weighting twenty one kilograms, was admitted at the Veterinary Teaching Hospital of the Federal University of Rio Grande do Sul (UFRGS) with a history of intermittent vomiting and diarrhea since it was a puppy. Because of the chronicity and nonspecifi c signs, additional tests were requested. Abdominal ultrasonography showed a round mass, measuring approximately 3.7 cm x 3.2 cm, suggesting a neoplasm. Blood pressure was measured and the mean value was 152 mmHg. Laboratory tests included a complete blood count, albumin (31.62 g/L), ala

Background: Endocrine tumors are considered rare in veterinary medicine. Studies suggest that only one or two per cent of these are primary neoplasms of the adrenal glands. Concerning the histological classifi cation of these masses, the most frequently occurring malignant neoplasms in dogs are adenocarcinomas and pheochromocytomas and, among the benign tumors, adenomas are the most common. Although much rarer, hemangiomas, myelolipomas, among others, may also occur. Dogs with this kind of neoplasm could be asyntomatic or show gastrointestinal signs, pain and urinary tract infection. Adrenalectomy is the treatment of choice and could be curative in most cases. This paper reports a case of two concurrent benign, rare adrenal neoplasms in a dog, emphasizing the clinical signs, diagnosis and treatment.Case: An eight-year-old, male castrated Chow-chow, weighting twenty one kilograms, was admitted at the Veterinary Teaching Hospital of the Federal University of Rio Grande do Sul (UFRGS) with a history of intermittent vomiting and diarrhea since it was a puppy. Because of the chronicity and nonspecifi c signs, additional tests were requested. Abdominal ultrasonography showed a round mass, measuring approximately 3.7 cm x 3.2 cm, suggesting a neoplasm. Blood pressure was measured and the mean value was 152 mmHg. Laboratory tests included a complete blood count, albumin (31.62 g/L), al

Uso dos marcadores tumoriais CEA, CYFRA21-1 e CA72-4 como ferramentas auxiliares no diagnóstico de efusões neoplásticas em cães

Introdução: Marcadores tumorais são substâncias produzidas por células neoplásicas ou pelo hospedeiro em resposta ao tumor, que podem ser detectadas em fl uidos corporais e utilizadas no manejo de pacientes com câncer. O fragmento de citoqueratina 19 (CYFRA 21-1) apresenta boa sensibilidade para carcinoma pulmonar de células escamosas e mesoteliomas, apesar de estar presente também no epitélio normal. O antígeno associado a câncer 72-4 (CA 72-4) é sensível para vários tipos de adenocarcinomas, principalmente na região gástrica. O antígeno carcinoembrionário (CEA) apresenta níveis elevados especialmente em neoplasmas de origem epitelial. O objetivo deste estudo foi investigar o desempenho dos marcadores tumorais bioquímicos CYFRA 21-1, CA 72-4 e CEA na diferenciação entre efusões neoplásicas e não neoplásicas de cães.Materiais, Métodos e Resultados: Trinta e duas amostras de efusões torácicas e abdominais caninas provenientes do atendimento clínico do Hospital de Clínicas Veterinárias da UFRGS foram escolhidas para as análises dos marcadores tumorais, classifi cando-se em grupo neoplásico e grupo não neoplásico. As amostras neoplásicas corresponderam a um mesotelioma, seis carcinomas, seis sarcomas, uma histiocitose maligna e dois linfomas. Os marcadores tumorais foram mensurados pelo método imunoenzimático ELISA sanduíche (Enzyme Linked Immunosorbent Assay), de acordo com instr

Uso dos marcadores imunocitoquímicos MOC-31 e D2-40 como auxílio diagnóstico em efusões neoplásticas caninas

Introdução: A análise citológica dessas efusões é importante para o diagnóstico, principalmente de malignidades, embora apresente baixa sensibilidade. A diferenciação entre os diversos tipos neoplásicos na citologia de efusões torna necessária a investigação de um painel imunocitoquímico válido, incluindo novos anticorpos como MOC-31 e D2-40. Estes anticorpos auxiliam na diferenciação entre mesoteliomas e carcinomas, enquanto que outros anticorpos, de imunorreatividade conhecida para a espécie canina, como a vimentina, a citoqueratina AE1/AE3, o CD3 e o CD79cy, auxiliam na detecção de sarcomas e linfomas. O objetivo deste estudo foi padronizar e incluir os marcadores imunocitoquímicos MOC-31 e D2-40 em um painel mínimo, que permita defi nir o tipo neoplásico em efusões caninas.Materiais, Métodos e Resultados: Quatorze amostras de efusões neoplásicas caninas foram obtidas do atendimento clínico do Hospital de Clínicas Veterinárias da UFRGS. Após a análise, os sedimentos das amostras foram fi xados em solução de formalina tamponada 10%, formando um pellet celular. Estes foram incluídos em parafi na e processados pelas técnicas histológicas de rotina. Aos cortes citológicos de cada amostra foram aplicadas as técnicas de imunocitoquímica (ICQ) pelo método estreptavidina-biotina ligada à peroxidase, para os anticorpos primários anti-citoqueratina, anti-vimentina, D2-40 e MOC-31. Pa

Comunicação científica: aspectos da intussuscepção dupla sem obstrução do lúmen intestinal em um cão

Um cão macho, SRD, de oito anos de idade, foi atendido apresentando vômito crônico e emagrecimento progressivo fazia cinco meses. Foram realizados exames laboratoriais e trânsito intestinal contrastado, sem sinais de obstrução. O exame endoscópico foi inconclusivo, sendo então indicada laparotomia exploratória, que demonstrou presença de intussuscepção, que foi retirada e explorada subseqüentemente, revelando-se ser do tipo dupla. PALAVRAS-CHAVE: Intussuscepção, cão, caquexia.

Uso da fluoxetina no tratamento da tricotilomania felina

Feline psycogenic alopecia occurs when cats lick their hair compulsively. Stress situations play a role in this disturbance, due to changes in neurohormone mechanisms. The introduction of a new animal or baby in the household can also be associated. Besides behavioral changes towards the animal, the use of anxiolytics is suggested to treat the disease. Fluoxetine was used in the treatment of 5 domestic cats with psycogenic alopecia, showing showing inhibition of licking attitude, with repilation within two to three months of use.

A tricotilomania ou alopecia psicogênica felina é uma dermatopatia de origem psicogênica, decorrente da lambedura compulsiva do pelame, realizada pelo gato em situações de estresse. Tal distúrbio decorre de alterações neuro-hormonais e pode associar-se à introdução de novos animais e/ou crianças no ambiente. Além de mudanças de manejo e atitude para com o animal, sugere-se o emprego de ansiolíticos no tratamento da doença. A fluoxetina foi utilizada no tratamento de cinco gatos domésticos com tricotilomania, apresentando inibição do comportamento de lambedura, com repilação após dois a três meses de terapia.

Treatment of naturally occurring canine ehrlichiosis with doxycycline, preceded or not by imidocarb dipropionate / Tratamento da erliquiose canina de ocorrência natural com doxiciclina, precedida ou não pelo dipropionato de imidocarb

Canine ehrliquiosis has become one of most important infectious diseases, especially due to its increasingly prevalence amongst dogs. Many treatment protocols have been proposed, but the association of imidocarb and doxycycline is frequently used because it shows an adequate therapeutic response. However, imidocarb can not be prescribed to some patients, which represents a paradox for many clinicians. The aim of this study was to evaluate the clinical response of doxycycline, preceded or not by imidocarb, for treating canine ehrlichiosis. Two groups of nine dogs were composed: the first was treated with doxycycline, whereas the second was treated with doxycycline and imidocarb. Results showed that both treatments were satisfactory, demonstrating that the clinical response did not depend on the use of imidocarb in the experiment.

A erliquiose tem despontado como uma das mais importantes enfermidades infecciosas, devido ao aumento da sua prevalência entre os cães. Diversos tratamentos já foram propostos para a doença, sendo que a associação de imidocarb e doxiciclina é rotineiramente empregada, apresentando adequada resposta terapêutica. Entretando, em alguns pacientes, o imidocarb não pode ser utilizado devido aos seus efeitos hepatotóxicos, representando um paradoxo para muitos clínicos. Com o objetivo de avaliar a resposta clínica da doxiciclina, precedida ou não do imidocarb, em casos de erliquiose canina, constituiu-se dois grupos de nove cães, sendo um deles tratado com doxiciclina e o outro com doxiciclina e imidocarb. Observou-se que ambos os tratamentos resultaram em melhora clínica. Assim, concluiu-se que neste estudo, a resposta terapêutica foi indiferente quanto ao uso ou não do imidocarb nos casos de erliquiose canina.

TREATMENT OF NATURALLY OCCURRING CANINE EHRLICHIOSIS WITH DOXYCYCLINE, PRECEDED OR NOT BY IMIDOCARB DIPROPIONATE / TRATAMENTO DA ERLIQUIOSE CANINA DE OCORRÊNCIA NATURAL COM DOXICICLINA, PRECEDIDA OU NÃO PELO DIPROPIONATO DE IMIDOCARB

Canine ehrliquiosis has become one of most important infectious diseases, especially due to its increasingly prevalence amongst dogs. Many treatment protocols have been proposed, but the association of imidocarb and doxycycline is frequently used because it shows an adequate therapeutic response. However, imidocarb can not be prescribed to some patients, which represents a paradox for many clinicians. The aim of this study was to evaluate the clinical response of doxycycline, preceded or not by imidocarb, for treating canine ehrlichiosis. Two groups of nine dogs were composed: the first was treated with doxycycline, whereas the second was treated with doxycycline and imidocarb. Results showed that both treatments were satisfactory, demonstrating that the clinical response did not depend on the use of imidocarb in the experiment.

A erliquiose tem despontado como uma das mais importantes enfermidades infecciosas, devido ao aumento da sua prevalência entre os cães. Diversos tratamentos já foram propostos para a doença, sendo que a associação de imidocarb e doxiciclina é rotineiramente empregada, apresentando adequada resposta terapêutica. Entretando, em alguns pacientes, o imidocarb não pode ser utilizado devido aos seus efeitos hepatotóxicos, representando um paradoxo para muitos clínicos. Com o objetivo de avaliar a resposta clínica da doxiciclina, precedida ou não do imidocarb, em casos de erliquiose canina, constituiu-se dois grupos de nove cães, sendo um deles tratado com doxiciclina e o outro com doxiciclina e imidocarb. Observou-se que ambos os tratamentos resultaram em melhora clínica. Assim, concluiu-se que neste estudo, a resposta terapêutica foi indiferente quanto ao uso ou não do imidocarb nos casos de erliquiose canina.

COMUNICAÇÃO CIENTÍFICA: ASPECTOS DA INTUSSUSCEPÇÃO DUPLA SEM OBSTRUÇÃO DO LÚMEN INTESTINAL EM UM CÃO

Um cão macho, SRD, de oito anos de idade, foi atendido apresentando vômito crônico e emagrecimento progressivo fazia cinco meses. Foram realizados exames laboratoriais e trânsito intestinal contrastado, sem sinais de obstrução. O exame endoscópico foi inconclusivo, sendo então indicada laparotomia exploratória, que demonstrou presença de intussuscepção, que foi retirada e explorada subseqüentemente, revelando-se ser do tipo dupla. PALAVRAS-CHAVE: Intussuscepção, cão, caquexia.

Uso da fluoxetina no tratamento da tricotilomania felina

Feline psycogenic alopecia occurs when cats lick their hair compulsively. Stress situations play a role in this disturbance, due to changes in neurohormone mechanisms. The introduction of a new animal or baby in the household can also be associated. Besides behavioral changes towards the animal, the use of anxiolytics is suggested to treat the disease. Fluoxetine was used in the treatment of 5 domestic cats with psycogenic alopecia, showing showing inhibition of licking attitude, with repilation within two to three months of use.

A tricotilomania ou alopecia psicogênica felina é uma dermatopatia de origem psicogênica, decorrente da lambedura compulsiva do pelame, realizada pelo gato em situações de estresse. Tal distúrbio decorre de alterações neuro-hormonais e pode associar-se à introdução de novos animais e/ou crianças no ambiente. Além de mudanças de manejo e atitude para com o animal, sugere-se o emprego de ansiolíticos no tratamento da doença. A fluoxetina foi utilizada no tratamento de cinco gatos domésticos com tricotilomania, apresentando inibição do comportamento de lambedura, com repilação após dois a três meses de terapia.