Comparison of systemic interleukin 10 concentrations in healthy dogs and those suffering from recurring and first time Demodex canis infestations.

OBJECTIVE: The objective of this study was to assess the interleukin 10 (IL-10) concentrations in the sera of dogs suffering from demodicosis. METHODS: Twenty-six dogs were distributed into three groups: demodicosis groups G1, n=11 (recurring disease) and G2, n=6 (first time occurrence), and a control group, G3, n=9 (healthy dogs). All the animals were subjected to skin scrape tests and blood harvesting for serum extraction. In G1 and G2 only those animals with Demodex canis positive skin tests were included, while healthy dogs were included in G3. To assess IL-10 levels the commercial Quantikine Canine IL-10 Immunoassay(®) (R&D Systems) kit was used. RESULTS: The mean IL-10 level obtained for G1 was 269.4 pg/ml (sd=290.8 pg/ml), for G2 it was 28.5 pg/ml (sd=19.7 pg/ml) while the mean for G3 was 11.9 pg/ml (sd=2.3 pg/ml). There was a significant difference between G1 and the other two groups. CONCLUSIONS: According to our results, dogs with reoccurring demodicosis have higher IL-10 levels than healthy dogs and those suffering the disease for the first time.

[Hepatic alveolar echinococcosis: a rare cause of recurrent, surgically curable abdominal pain in children]. / L'échinococcose alvéolaire hépatique : une cause exceptionnelle de douleurs abdominales récurrentes, chirurgicalement curable, chez l'enfant.

Hepatic alveolar echinococcosis is a rare parasitic zoonosis, potentially lethal in childhood. It is due to Echinococcosis multilocularis whose larva insidiously develops in the liver. We report the case of a 13-year-old girl, living in the Vosges Mountains, followed for recurrent abdominal pain, with recent worsening. Diagnosis of alveolar echinococcosis was immediately suspected based on the liver ultrasound scan and then confirmed by imaging (CT scan, NMR) and serology. A curative surgical treatment (segmentectomy) was performed 3 months after diagnosis, under oral albendazole treatment, maintained for at least 2 years. Hepatic alveolar echinococcosis usually has a negative prognosis, except if diagnosed early, which allows rapid surgical treatment, as in our patient.

PDE4 control on cAMP/PKA compartmentation revealed by biosensor imaging in neurons.

Electrophysiological recordings (using the slow-AHP potassium current) together with novel biosensor imaging methods (with AKAR and Epac sensors) were used in preparations of rodent brain slices to record PKA activation in real time and in individual neurons. The experiments revealed the propagation of the PKA signal from the membrane to the cytosol and eventually to the nucleus. The experiments show how the geometry of the neurons combined with phosphodiesterase activities (mostly rolipram-sensitive PDE4) contributes to a functional compartmentation of the cAMP in subcellular domains.

[Alcohol and drug consumption among students in Pachuca, Hidalgo]. / Consumo de alcohol y drogas en estudiantes de Pachuca, Hidalgo.

OBJECTIVE: To determine the prevalence of alcohol and drug consumption and its relationship to sociodemographic variables, leisure activities, antisocial behavior, family norms and conflicts, among others. MATERIAL AND METHODS: Data derive from a representative survey of 1,929 students of junior high and high school, conducted in 1996 in the city of Pachuca, Hidalgo, Mexico. Of these, 44.9% were boys and 52.5% were girls; mean age was 14. A self-applied questionnaire, prepared by the WHO together with some countries, among them Mexico, was completed by the studied subjects, and included indicators of alcohol and drug consumption. RESULTS: Of the total sample, 47.9% had tried alcohol, and 12.6% had drunk large quantities--5 drinks or more per sitting--during the month previous to the survey. Preferred drinks are beer and "coolers", which they buy at shops where no identification is required and drink at home or at friend's homes. With respect to drugs, 5.1% had tried illegal or medical drugs without prescription, in particular inhalants, marihuana and tranquilizers. More boys consumed illegal drugs, and more girls medical drugs without prescription. Boys, who are also older, more frequently consumed alcohol and drugs and were more often employed during the previous year at part-time jobs. High alcohol level and drug consumers were characterized by their frequent report of being bored in their free time, drinking with friends and enrolling in antisocial behavior. With respect to family norms, they follow them less and show less interest in doing so. An elevated percentage informed that their parents fight frequently, that they have sought help for this reason and have intended separation. CONCLUSIONS: Groups who drink more alcohol and use other drugs, in contrast with nonusers, presented more behavioral problems, more outdoors activities that included drinking with friends, more antisocial behavior, had a distant relationship with their families sharing few activities with them, an showed little interest in following family rules and perceiving conflicts within their families.

[Prevalence of sexual abuse in students and its relation with drug abuse]. / Prevalencia de abuso sexual en estudiantes y su relación con el consumo de drogas.

OBJECTIVE: To determine the prevalence of sexual abuse among high school (secondary and preparatory) students, male and female, throughout Mexico, and its relationship with drug abuse. MATERIAL AND METHODS: Data were obtained from the National Survey of Drug Use in Schools applied in November and December, 1991. A total of 61,779 students, 51.8% men and 47.1% women, with a mean age of 14.4 years completed the self-applied questionnaire. Sexual abuse was explored from the perspective of the abusers and of the victims. RESULTS: The prevalence of sexual abuse in adolescent victims was 4.3% and no statistically significant differences were found between sexes. The prevalence of sexual aggressors was 2.5%. Men coerced someone else in a higher proportion than women. Adolescent women experienced sexual abuse at a younger age than men and they also reported a higher percentage of intrafamily abuse. Men reported friends as the most frequent aggressors. Victims and aggressors of both sexes reported a significantly higher drug consumption than students without these antecedents. CONCLUSIONS: The differences in the experience of sexual abuse between men and women are described. In particular, the fact that sexual abuse in men mainly occurs outside the family sphere, while in women it is mainly within the family and at a younger age than in men. Additionally, the need for further research focusing on the consequences on mental health of infantile and adolescent sexual abuse and drug consumption is emphasized, considering the characteristics of each gender.

Image restoration through aberrant media by optical phase conjugation in a type II three-wave mixing interaction.

Restoration of an image through an aberrant plate has been achieved by use of optical phase conjugation in a type II parametric interaction in which the amplified signal and idler waves are reflected back through the aberrant medium. The resolution of the restored phase-conjugate images is equal to 0.18 mm, and the amplification gain is ~4dB.