ABSTRACT
El cáncer de próstata (CP) es el tumor más frecuente en varones en Occidente y la quinta causa de muerte relacionada con el cáncer. El uso de radioligandos antígeno prostático específico de membrana (PSMA) ha supuesto un importante avance tanto en su diagnóstico, a través de la imagen molecular de tomografía por emisión de positrones (PET), como en su tratamiento en fases avanzadas de la enfermedad. En este artículo, se hace una revisión de la aportación de los estudios PET con radioligandos PSMA en la estadificación inicial, en la detección tumoral en la recidiva bioquímica (elevación del antígeno prostático específico [PSA]) tras un tratamiento con intención curativa, y en los estadios más avanzados de la enfermedad (CP resistente a la castración o CPRC). Se analiza, además, la aportación de la terapia con radioligandos PSMA (PSMA-TRL) en pacientes con CPRC que progresan a la terapia estándar (AU)
Prostate cancer (PC) is the most common tumor in men in the West and the fifth leading cause of cancer-related death. The use of prostate-specific membrane antigen (PSMA) radioligands has represented an important advance in both in the diagnosis by positron emission tomography (PET) molecular imaging and the treatment of advanced stages of the disease. This article reviews the contribution of PET studies with PSMA radioligands in the initial staging, tumor detection in biochemical recurrence (elevation of PSA) after treatment with curative intent, and in the more advanced stages of the disease (castration-resistant PC [CRPC]). The contribution of PSMA radioligand therapy in CRPC patients who progress to standard therapy is also analyzed (AU)
Subject(s)
Humans , Male , Prostatic Neoplasms, Castration-Resistant/diagnostic imaging , Prostatic Neoplasms, Castration-Resistant/therapy , Prostate-Specific Antigen , Radioligand Assay , Positron-Emission Tomography , Neoplasm Staging , Neoplasm Recurrence, LocalABSTRACT
Prostate cancer (PC) is the most common tumor in men in the West and the fifth leading cause of cancer-related death. The use of PSMA radioligands has represented an important advance both in its diagnosis, through PET molecular imaging, and in its treatment in advanced stages of the disease. This article reviews the contribution of PET studies with PSMA radioligands in initial staging, in tumor detection in biochemical recurrence (elevation of PSA) after treatment with curative intent, and in the more advanced stages of the disease (castration resistant PC or CRPC). The contribution of PSMA radioligand therapy (PSMA-RLT) in CRPC patients who progress to standard therapy is also analyzed.
Subject(s)
Carcinoma , Prostatic Neoplasms, Castration-Resistant , Dipeptides , Heterocyclic Compounds, 1-Ring , Humans , Male , Prostate/pathology , Prostatic Neoplasms, Castration-Resistant/pathologySubject(s)
Humans , Female , Middle Aged , Tomography, Emission-Computed, Single-Photon/methods , Tomography, Emission-Computed, Single-Photon , Echinococcosis, Hepatic/complications , Kidney Neoplasms/diagnosis , Nephrectomy/methods , Diagnosis, Differential , Tomography, Emission-Computed, Single-Photon/trends , Kidney NeoplasmsSubject(s)
Bacterial Infections/diagnostic imaging , Citrates , Echinococcosis/diagnostic imaging , Gallium Radioisotopes , Gallium , Kidney Diseases, Cystic/diagnostic imaging , Radiopharmaceuticals , Tomography, Emission-Computed, Single-Photon , Tomography, X-Ray Computed , Bacterial Infections/complications , Corynebacterium Infections/complications , Corynebacterium Infections/diagnostic imaging , Diagnosis, Differential , Echinococcosis/complications , Echinococcosis/surgery , Humans , Kidney Diseases, Cystic/etiology , Kidney Diseases, Cystic/surgery , Kidney Neoplasms/diagnosis , Nephrectomy , Pseudomonas Infections/complications , Pseudomonas Infections/diagnostic imaging , Staphylococcal Infections/complications , Staphylococcal Infections/diagnostic imagingABSTRACT
Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H. Although the loss of these dependence receptors' expression has been described as a selective advantage for tumor growth and progression in numerous cancers, recent observations have shown that some tumors may use an alternative strategy to block dependence receptor-induced programmed cell death: the autocrine expression of netrin-1. This alternative strategy has been observed in a large fraction of aggressive breast cancers, neuroblastoma, pancreatic adenocarcinoma, and lung cancer. This observation is of potential interest regarding future targeted therapy, as in such cases interfering with the ability of netrin-1 to inhibit DCC or UNC5H-induced cell death is associated with apoptosis of netrin-1-expressing tumor cells in vitro, and with inhibition of tumor growth or metastasis in different animal tumor models. The understanding of the mechanism by which netrin-1 inhibits cell death is therefore of interest. Here, we show that netrin-1 triggers the multimerization of both DCC and UNC5H2 receptors, and that multimerization of the intracellular domain of DCC and UNC5H2 is the critical step to inhibit the proapoptotic effects of both of these receptors. Taking advantage of this property, we utilized a recombinant specific domain of DCC that (i) interacts with netrin-1 and (ii) inhibits netrin-1-induced multimerization, to trigger apoptosis in netrin-dependent tumor cells.
Subject(s)
Apoptosis , Neoplasms/metabolism , Nerve Growth Factors/pharmacology , Receptors, Cell Surface/metabolism , Tumor Suppressor Proteins/pharmacology , Animals , Cell Line , Chickens , DCC Receptor , Disease Models, Animal , Humans , Netrin Receptors , Netrin-1 , Protein Multimerization/drug effects , Recombinant Proteins/pharmacology , Tumor Suppressor Proteins/metabolismABSTRACT
Objetivo: Analizar los resultados anatomicofuncionales de la operación de Vecchietti por laparoscopia para la creación de una neovagina.Material y métodos: Estudio tipo caso-control: grupo caso formado por 6 pacientes con el síndrome de Rokitansky a las que se creó una neovagina según la técnica de Vecchietti por laparoscopia; grupo control formado por un histórico de 5 pacientes intervenidas según la técnica de McIndoe. Se analizaron las variables: tiempo y complicaciones quirúrgicas, tiempo de estancia hospitalaria, complicaciones posquirúrgicas y longitud de vagina. Los resultados funcionales se analizaron mediante un cuestionario de sexualidad (FSFI).Resultados: Ambos grupos presentaron resultados anatómicos similares. Se hallaron diferencias significativas en el tiempo de ingreso hospitalario y en las complicaciones posquirúrgicas. Los resultados funcionales en las pacientes con relaciones sexuales activas fueron similares a la población normal.Conclusión: Con la técnica de Vecchietti por laparoscopia, se obtienen buenos resultados anatómicos y funcionales, se reducen el tiempo de ingreso hospitalario y las complicaciones posquirúrgicas (AU)
Subject(s)
Adult , Female , Humans , Laparoscopy/methods , Sexuality/physiology , Sexuality/psychology , Postoperative Complications/diagnosis , Postoperative Complications/physiopathology , Genitalia, Female/abnormalities , Genitalia, Female/surgery , Vagina/surgery , Vagina/physiology , Vagina/abnormalities , Control Groups , Amenorrhea/surgery , Amenorrhea/diagnosisABSTRACT
El embarazo implantado sobre la cicatriz de una cesárea anterior constituye la localización más infrecuente de los embarazos ectópicos y, posiblemente, es una de las más peligrosas por el riesgo de rotura uterina y hemorragia que comporta. Se trata de una entidad rara, con pocos casos publicados en la bibliografía mundial y en la que el diagnóstico diferencial puede llegar a ser muy dificultoso. La incertidumbre en los criterios diagnósticos y en su pronóstico hace que no exista hoy un consenso aceptado sobre cuál es la mejor opción terapéutica (AU)
