[Role of oral candidiasis as a predictive marker of tuberculosis in patients with HIV infection]. / Papel de la candidiasis oral como marcador predictivo de enfermedad tuberculosa en los pacientes con infección por virus de inmunodeficiencia humana (VIH).

We present a prospective follow-up study of 114 patient infected by Candida and HIV, in order to assess the role of oral candidiasis (OC) as a predictive marker of tuberculosis and opportunistic infections (OI) which define the Acquired Immunodeficiency Syndrome (AIDS). We compared the study group with an homogeneous control group of 152 patients infected by HIV without OC during the same period. TBC findings in the first group were discriminant with respect to the control group (p less than 0.0001) with and average period of 2.5 months between the diagnosis of OC and the development of TBC. These findings suggest that OC is an early evolutive marker of TBC and a late marker of AIDS.

[Generalized persistent lymphadenopathy syndrome in parenteral drug addicts. Lymph node biopsy study of 41 patients]. / Síndrome de la linfoadenopatía persistente generalizada en adictos a drogas por vía parenteral. Estudio biópsico ganglionar de 41 pacientes.

Of a total of 41 VIH positive patients, parenteral drug addicts, with persistent generalized lymphadenopathy syndrome, we performed 43 lymph-node biopsies. In two sequential biopsies, 2 and 12 months respectively after the first biopsy, were carried-out. After a clinical follow-up (ranging between 4-28 months) 12 patients (24.3%) were qualified as SIDA cases according to CDC-1987 criteria. Lymph-node biopsy was of diagnostic or prognostic value in 16.27% and in 6.97% respectively. Upon comparing histological types and peripheral lymphocyte subsets it was demonstrated how the forms of major morphological deterioration tend to associate with a lower number of OKT4+ lymphocytes and a lower relation OKT4+/OKT8+.

[Epithelioid angiomatosis and HIV infection. A neoplastic or infectious proliferative disease?]. / Angiomatosis epiteloide e infección por VIH. Enfermedad proliferativa neoplásica o infecciosa?

A case of "epithelioid angiomatosis" detected in a homosexual patient with positive seric HIV is presented. The skin lesions cytoplasm rich, closed y clumped together, with scanty stromal compound. Warthin-Starry staining [correction of tintions] did not show Bacillus causing "cat scratch disease". We review and analyse the features of this type of proliferation in patients infected with HIV.

[Syndrome of persistent generalized lymphadenopathy with development into a gastric lymphoma]. / Síndrome de las linfoadenopatías generalizadas persistentes con evolución a linfoma gástrico.

A man with previous addiction to parenteral drugs presented infection by human immunodeficiency virus (HIV) with persistent generalised lymph node enlargement. Sixteen months after diagnosis, he developed intermediate-grade lymphoma of the stomach. Partial response was achieved by chemotherapy, and the patient presented pulmonary and meningeal tuberculosis which led him to exitus.

[Thrombopenic purpura associated with human immunodeficiency virus infection. Analysis of 24 cases]. / Púrpura trombopénica asociada a infección por virus de la inmunodeficiencia humana. Análisis de 24 casos.

In 24 cases of thrombopenic purpura associated with human immunodeficiency virus infection the clinical, immunological and therapeutic features were evaluated. Thrombopenia resulted in clinical manifestations in 20 patients. Splenomegaly was found in only one fourth of patients. Antiplatelet antibodies were found in 9 patients, and thrombopenia was associated with anemia in 37% of cases and with leukopenia in 21%. Bone marrow examination showed megakaryocyte hyperplasia in two thirds of the patients. The major immunological abnormalities were an inverted helper/suppressor T lymphocytes ratio, a reduction in the number of helper T lymphocytes, polyclonal hypergammaglobulinemia, and increased serum concentrations of circulating immunocomplexes. The different therapeutic modalities, steroids, vincristine, danatrol and plasma exchange, resulted in short responses; only two patients had normal platelet counts. The median follow-up was 14 months; during this time three patients fulfilled the criteria of acquired immunodeficiency syndrome.