[Effect of experimental hyper- and hypoinsulinemia on the level of cholesterol lipoproteins in aging rats]. / Vliianie éksperimental'noi giper- i gipoinsulinemii na uroven' kholesterina lipoproteidov pri starenii u krys.

A study was made of the effect of hyper- and hypoinsulinemia on blood serum lipoproteins of 5-6-month and 24-26 month old rats. Total cholesterol levels, cholesterol fraction concentration in lipoproteins, the level of insulinemia, and age showed correlation. Administration of insulin had a positive effect on the serum lipid spectrum, increasing the HDL-C content in aged animals. In alloxan diabetes, VLDL-C concentration in serum was on the increase. Alterations were more pronounced in young rats.

[Various indices of lipid metabolism in patients with gastroduodenal pathology]. / Nekotorye pokazateli lipidnogo obmena u bol'nykh s gastroduodenal'noi patologiei.

Lipid metabolism was studied in patients with impairments of gastroduodenal tract before and after treatment. The data obtained suggest that the treatment of these patients should involve both antioxidants and angioprotective drugs in order to prevent vascular deteriorations.

[Age characteristics of the hypoglycemic effect of glibenclamide]. / Vozrastnye osobennosti gipoglikemicheskogo éffekta glibenklamida.

A comparative study of glibenclamide (G) effect on glucose and IRI levels in rats aged 4 to 5 and 24 to 28 mos. following 18 h starvation was performed. One hour after administration of G at a dose of up to 1 mg/kg of body mass glycemia did not change but in 3 and 5 h it decreased more markedly in old rats. The elevation of a G dose up to 5 mg/kg of body mass raised the hypoglycemic effect in young animals causing no changes in old rats. Glibenclamide at a dose of 1 mg/kg of body mass did not change the IRI level in the young rats' blood and increased it in the old rats 2-3 h after administration. A dose of 5 mg determined a higher IRI level in the young rats' blood and decreased this effect in the old animals.