ABSTRACT
OBJECTIVE: To evaluate the different fractions of dried leaves of Ficus religiosa Linn for analgesic and anti-inflammatory activity using different models of pain and inflammation MATERIALS AND METHODS: The analgesic activity of F. religiosa carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-granuloma formation in rats. Five different fractions (FRI, FRII, FRIII, FRIV and FRV) of F. religiosa at the dose level of 20 and 40 mg/kg, p.o were tested. RESULTS: The fraction FRI (40 mg/kg, p.o.) and FRIII (40 mg/kg, p.o) were found to be more effective (P<0.01) in preventing carrageenan induced rat paw edema, cotton pellet granuloma formation, and acetic acid induced writhing compared to the other fractions. FRI (20 mg/kg, p.o.) and FRIII (20 mg/kg, p.o.) were also found to be more effective in increasing latency period in tail flick method. CONCLUSION: Out of five different fractions of F. religiosa leaves tested, FRI and FRIII possess potent analgesic and anti-inflammatory activities against different models of inflammation and pain.
ABSTRACT
OBJECTIVE: To investigate anticancer activity of different fractions of Tephrosia purpurea [TP] (Sharapunkha, Fabaceae) and Ficus religiosa [FR] (Peepal, Moraceae). METHODS: The fractions of TP and FR were prepared and tested for in vitro anticancer activity using human MCF 7 cell line by trypan blue exclusion method. RESULTS: The result showed that among all these fractions of TPI, TPIII, FRI and FRIII showed better anticancer activity compared to other fractions. The IC(50) value for TPI (152.4 µM), TPIII (158.71 µM), FRI (160.3 µM) and for FRIII (222.7 µM) was observed. CONCLUSIONS: The present study shows anticancer potential of TP and FR fractions in MCF 7 cell line.
