ABSTRACT
21 children who died from meningococcemia were studied. Shock disturbances of the microcirculation and thrombocytic part of hemostasis prevailed within first hours of the disease in the form of adrenal hemorrhages and brain edema as immediate cause of death. With an increase of the disease duration, aggregational thrombocytopenia, generalized microthrombosis, coagulopathy, fibrinolysis activation resulted in massive hemorrhages in a number of organs and tissues and manifested in the syndrome of polyorganic failure. No significant differences were found depending upon treatment.
Subject(s)
Hematologic Diseases/etiology , Hematologic Diseases/pathology , Meningococcal Infections/complications , Adrenal Gland Diseases/etiology , Brain Edema/etiology , Child, Preschool , Hemorrhage/etiology , Hemostasis/physiology , Humans , Infant , Meningococcal Infections/blood , Meningococcal Infections/pathology , Multiple Organ Failure/etiology , Shock, Septic/etiologyABSTRACT
Using a highly mutable FM/w oc system, we have established a new allele of ssa40aSc mutation whose phenotype is identical to ssa40aNs compound described in the literature. The following features are characteristic of the ssa40aSc flies phenotype: (1) the increased number of sex comb teeth, (2) complete fusion of tarsal segments, and (3) the decreased bristle size corresponding to that of ss flies. The first two features are evidence for the impaired stem cell proliferation in the antennal and leg imaginal discs which are determined to form distal structures. This assumption was experimentally confirmed when we transplanted leg imaginal discs from III instar larvae of different age into prepupae. The observed phenomenon is probably due to the defects of the Antp and Pc translation products binding site in the ss locus.
Subject(s)
Alleles , Extremities/anatomy & histology , Genes, Homeobox/genetics , Genetic Variation/genetics , Sense Organs/cytology , Stem Cells/cytology , Animals , Cell Division/genetics , Crosses, Genetic , Drosophila melanogaster , Mutation/genetics , PhenotypeSubject(s)
Neuromuscular Junction/ultrastructure , Animals , Annelida/anatomy & histology , Ascaridia/anatomy & histology , Chordata, Nonvertebrate/anatomy & histology , Hydra/anatomy & histology , Microscopy, Electron , Neuromuscular Junction/physiology , Platyhelminths/anatomy & histology , Species Specificity , Starfish/anatomy & histologyABSTRACT
The pharyngeal retractor muscle of Helix lucorum is innervated by two symmetrical nerves which contain axons of two types forming myoneural junctions with the muscle cells. Type I junctions correspond to thick axons. These axon terminals which contain a large number of spherical, clear vesicles (41 +/- 5 nm) and a smaller number of dense-cored vesicles (67 +/- 3 nm) make contacts mainly with noncontractile sarcoplasmic processes of muscle cells. Type II junctions correspond to thin axons containing many of granules. Their axon terminals contact with contractile parts of muscle cells and contain a heterogenous population of vesicles: small spherical clear vesicles (44 +/- 2 nm), dense-cored vesicles and numerous irregularly outlined granules with fine-granular content (135 +/- 5 nm). Space between muscle cell is usually wide (50 nm and more) with the exception of sarcoplasmic processes where the gap may be less than 10 nm.