[The hypoazotemic and diuretic action of lespeflan in acute kidney failure]. / Gipoazotemicheskoe i dureticheskoe deistvie lespefalana pri ostroi pochechnoi nedostatochnosti.

Hypoazotemic and diuretic effects of a new bioflavonoid drug lespephlan made in Russia have been tested in a dose 2 ml/kg to treat acute renal failure induced by mercury bichloride solution (a dose 2 mg/kg). The data were obtained on lespephlan ability to reduce blood levels of urea, creatinine and activate their renal elimination, to enhance diuresis, sodium clearance, glomerular filtration. Water and electrolyte release were also changeable by angiotensin aldosterone system. Mechanism of lespephlan hypoazotemic action is related to hepatic arginase inhibited activity as this enzyme plays a key role in detoxication of nitrous products urea and creatinine.

[The mechanism of action of the bioflavonoid lespeflan and the antihypoxant TB-4 on nitrogen metabolism in animals with acute kidney failure]. / K mekhanizmu deistviia bioflavonoida lespeflana i antigipoksanta TB-4 na azotistyi obmen u zhivotnykh s ostroi pochechnoi nedostatochnost'iu.

The changes in the levels of urea and creatinine caused by the new native preparation lespeflanum and the antihypoxant TB-4 were studied in animal experiments. The agents tested produced a significant hypoazotemic effect in acute renal failure. Lespeflanum showed diuretic and natriuretic effects in healthy animals, elevated plasma aldosterone levels and decreased hepatic arginase activity. There was a normalization of thioldisulfide metabolism in patients treated with lespeflanum and TB-4. The hypoazotemic effect of lespeflanum was due both to its anabolic and anticatabolic effects. Lespeflanum is recommended for wide clinical application to treat patients with chronic renal failure.

[Characteristics of the action of nitroglycerin on the hemodynamics of patients with ischemic heart disease in relation to the content of SH groups of the blood serum and the tolerance for physical loading]. / Osobennosti deistviia nitroglitserina na gemodinamiku u bol'nykh ishemicheskoi bolezn'iu serdtsa v zavisimosti ot soderzhaniia SH-grupp v syvorotke krove i tolerantnosti k fizicheskoi nagruzke.

The authors examined 196 patients who had survived myocardial infarction and 21 persons without signs of myocardial ischemia. Nitroglycerin test with subsequent control of myocardial contractility, hemodynamics and blood serum content of SH-groups indicated that the level of SH-groups could serve as a prognostic criterion of efficacy of nitrates (inverse correlation).