ABSTRACT
It has been shown that trophoblastic beta 1-glycoprotein (TBG) and placental alpha 2-microglobulin (PAMG-2) in concentrations 60-120 micrograms/ml suppresses both the inductive and proliferative phase of unidirectional mixed lymphocyte reaction in mice, as well as proliferative responses to phytohemagglutinin or pokeweed mitogen. TBG protein was more effective. The proteins were not toxic for lymphocytes.
Subject(s)
Alpha-Globulins/pharmacology , Immunosuppressive Agents/pharmacology , Pregnancy Proteins/pharmacology , Pregnancy-Specific beta 1-Glycoproteins/pharmacology , Animals , Cell Survival/drug effects , Depression, Chemical , Humans , Lymphocyte Activation/drug effects , Lymphocyte Culture Test, Mixed , Male , Mice , Mice, Inbred BALB C , Mice, Inbred C57BL , Mice, Inbred CBA , Time FactorsSubject(s)
Antibody Formation/drug effects , Hormones/immunology , Immunity, Cellular/drug effects , Pregnancy/drug effects , Animals , Chorionic Gonadotropin/immunology , Epitopes , Estrogens/immunology , Female , Fetal Viability/drug effects , Humans , Immune Tolerance/drug effects , Immunization , Placental Lactogen/immunology , Progesterone/immunology , T-Lymphocytes/immunology , Transplantation Immunology/drug effects , Transplantation, HomologousSubject(s)
Fetus/immunology , Maternal-Fetal Exchange , Pregnancy , Transplantation Immunology , Animals , B-Lymphocytes/immunology , Cricetinae , Female , Gestational Age , Graft Rejection , Graft vs Host Reaction , Guinea Pigs , Histocompatibility Antigens , Humans , Immune Tolerance , Male , Mice , Placenta/immunology , Rats , Skin Transplantation , Species Specificity , T-Lymphocytes/immunology , Thymus Gland/immunology , Transplantation, Heterologous , Transplantation, HomologousABSTRACT
The development of the graft-versus-host reaction (GVHR) in the F1(1CBA X C57BL/6 hybrid mice after the transplantation of spleen cells from the C57BL/6 parent donor resulted in a strong inhibition of the serum interferon production induced by the intraperitoneal injection of the Newcastle disease virus. In vitro with the mouse bone marrow cells during the development of the GVHR the interferon response was first reduced and then disappeared completely. The described phenomenon could therefore serve as an index of the development of the GVHR.
Subject(s)
Graft vs Host Reaction , Interferons/biosynthesis , Spleen/transplantation , Animals , Bone Marrow/immunology , Bone Marrow Cells , Hybridization, Genetic , Mice , Mice, Inbred CBA , Mice, Inbred Strains , Transplantation, HomologousSubject(s)
Parabiosis , Transplantation/adverse effects , Anemia/genetics , Animals , Animals, Laboratory , Antigen-Antibody Reactions , Antigens, Heterophile , Cricetinae , Dogs , Female , Histocompatibility , Hybridization, Genetic , Immune Tolerance , Inbreeding , Male , Mice , Mice, Inbred Strains , Molecular Biology , Polycythemia/genetics , Rabbits , Rats , Time Factors , Transplantation Immunology , Transplantation, Homologous/adverse effectsABSTRACT
The article presents results of morphological, morphometric and cytochemical investigations of 100 placentae obtained in women who suffered from nephropathy of various degrees, and of placentae of mice with induced "graft versus host" reaction during pregnancy, and also of organs of two fetuses born to mothers who suffered from nephropathy of the III degree. In severe forms of late toxemia placentae, regularly showed infiltration of its structural elements with cells of the type of microlymphocytes with lytic properties. These changes occurred against the background of the placental metabolism turning into anaerobic respiration and they revealed a considerable degree of similarity to the changes in placentae of mice following the induction of the reaction "graft versus host". The morphological picture in lymphoid and other organs of the two investigated fetuses resembled very much that in "runt" disease.
